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PhenX RISING

Background

PhenX RISING (Real world, Implementation, and SharING) was a group of seven investigators funded by National Human Genome Research Institute (NHGRI) and the Office of Behavioral and Social Sciences Research (OBSSR) to incorporate PhenX measures into ongoing studies. Between 2011 and 2012, these researchers selected and evaluated PhenX measures for use in their own research and recommended improvements to the PhenX Toolkit.

Among the seven groups, 76 PhenX measures were added to existing studies. The measures added included demographics, psychosocial risk factors, psychiatric assessments, and a variety of exposures. Each group added between 4 and 37 measures with five groups adding more than 20 measures. In all, 55 of the 76 measures were shared by two or more groups, providing common ground for future cross-study analysis.

PhenX RISING provided a cross-section of different study designs, populations, and topics, including single site studies, multi-center studies, genetics consortia, and biobanks. They include studies of children as young as three years old through adolescence and adulthood, as well as one with a large population of centenarians. The projects addressed the role of genes and environment in psychopathology and behavior, neuro-imaging and genomics; the determinants of longevity, and the genetics of conditions such as diabetes, cataracts, and high cholesterol.

The seven studies funded under PhenX RISING (NOT-HG-11-009) were:

    PI / InstitutionStudy NameFunding Agency
    Allison Aiello, PhD, University of Michigan, Ann Arbor Ecologic Stressors, Post-Traumatic Stress Disorder, and Drug Use in DetroitNational Institute on Drug Abuse
    Robert Bilder, PhD (Co-Chair), University of California, Los Angeles Human Translational Applications CoreNational Institute of Mental Health
    Terry Jernigan, PhD, University of California, San Diego Creating a Pediatric Imaging-Genomics Data ResourceNational Institute on Drug Abuse
    Catherine McCarty, PhD, (Co-Chair), Essentia Institute of Rural Health Genome-Wide Study of Cataract and Low HDL in Personalized Medicine Research ProjectNational Human Genome Research Institute
    Dharambir Sanghera, PhD, University of Oklahoma, Oklahoma City Genome-Wide Association Scan to Identify Risk Genes for Type 2 Diabetes in Asian IndiansNational Institute of Diabetes and Digestive and Kidney Diseases
    Timothy Strauman, PhD, and Ahmad Hariri, PhD, Duke University Self-Regulation Failure: Identifying and Modifying a Risk PhenotypeNational Institute on Drug Abuse
    Yi Zeng, PhD, Duke University Determinants of Healthy Longevity in ChinaNational Institute on Aging

List of Measures

A spreadsheet containing the list of measures captured by each PhenX RISING investigator can be downloaded here.

Data Use Agreement

A copy of the PhenX RISING Data Use Agreement (DUA) can be downloaded here.

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