PhenX Toolkit: Domains

Showing 1 to 21 of 21 protocols

Select	Protocol	ID
	Arterial Blood Gas (ABG) Davis, M.D., et al. AARC clinical practice guideline: Blood gas analysis and hemoximetry. Respir Care, 2013	#090202
	Biomarker of exposure to nicotine-containing products - Saliva Bernert JT, et al. Comparison of serum and salivary cotinine measurements by a sensitive high-performance liquid chromatography-tandem mass spectrometry method as an indicator of exposure to tobacco smoke among smokers and nonsmokers. Anal Toxicol, 2000	#091708
	Biomarker of exposure to nicotine-containing products - Serum Bernert JT, et al. Interlaboratory comparability of serum cotinine measurements at smoker and nonsmoker concentration levels: a round-robin study. Nicotine Tob Res, 2009	#091709
	Biomarker of exposure to nicotine-containing products - Urine Wang L, et al. Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine. CANCER EPIDEM BIOMAR, 2018	#091707
	Bronchodilator Responsiveness (BDR) National Institutes of Health (NIH), COPDGene Study Clinical Center Manual of Procedures, 2009	#090301
	Chest Computed Tomography (CT) Genetic Epidemiology of COPD Clinical Center Manual of Procedures, 2014	#090402
	Exercise Capacity/Six-Minute Walk Test Six-Minute Walk Test (6MWT)	#090602
	Immunoglobulin E (Total and Specific) Williams, P. B., et al, Analytic precision and accuracy of commercial immunoassays for specific IgE: Establishing a standard, J ALLERGY CLIN IMMUN, 2000	#090701
	Peak Expiratory Flow Rate (PEFR) Miller, M. R., et al, Standardization of spirometry. Series “ATS/ERS task force: Standardization of lung function testing.”, EUR RESPIR J, 2005	#090801
	Personal and Family History of Respiratory Symptoms/Diseases - Adult American Thoracic Society-Division of Lung Diseases Questionnaire (ATS-DLD 78) & Genetic Epidemiology of COPD Study (COPDGene)	#090901
	Personal and Family History of Respiratory Symptoms/Diseases - Child International Study of Asthma and Allergies in Childhood (ISAAC) Manual	#090902
	Pulse Oximetry (Exercise) AARC Clinical Practice Guideline: Exercise Testing for Evaluation of Hypoxemia and/or Desaturation: revision & update. Resp Care, 2001	#091001
	Pulse Oximetry (Rest) World Health Organization (WHO), Pulse oximetry training manual, 2011	#091102
	Quality of Life as Affected by Respiratory Disease St. Georges Respiratory Questionnaire (SGRQ)	#091301
	Respiratory Rate - Adult Potter, P. A., et al. Fundamentals of Nursing, 1985	#091403
	Respiratory Rate - Child Wallis, L. A., Healy, et al, Age related reference ranges for respiration rate and heart rate from 4 to 16 years, ARCH DIS CHILD, 2005	#091402
	Respiratory Rate - Infant Fleming, S, et al. Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: A systemic review of observational studies. Lancer, 2011	#091404
	Sleep Apnea - Adult Berlin Questionnaire	#091501
	Sleep Apnea - Child The Pediatric Sleep Questionnaire (PSQ), Version 070424	#091502
	Spirometry - Adult Miller, M. R., et al, Standardization of spirometry. Series “ATS/ERS task force: Standardization of lung function testing.”, EUR RESPIR J, 2005	#091601
	Spirometry - Child Beydon, N., et al, An official American Thoracic Society/European Respiratory Society statement: Pulmonary function testing in preschool children, AM J RESP CRIT CARE, 2007	#091602

Showing 1 to 21 of 21 protocols

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Release Date:

January 29, 2010; reviewed November 17, 2017

Scope of Domain:

Scope Elements	Final Protocols To Toolkit (21)
Personal History of Conditions and Symptoms
Pneumonia, sarcoidoses	Personal and Family History of Respiratory Symptoms/Diseases (Adult and Child)
Chronic obstructive pulmonary disease (COPD)	Personal and Family History of Respiratory Symptoms/Diseases (Adult and Child)
Lung cancer
Symptoms, such as wheezing, shortness of breath	Quality of Life as Affected by Respiratory Disease
Trauma (acute respiratory disorder)
Allergic reactions to drugs
Anemia
Bronchitis, pleurisy	Personal and Family History of Respiratory Symptoms/Diseases (Adult and Child)
Asthma	Personal and Family History of Respiratory Symptoms/Diseases (Adult and Child)
Sleep apnea, sleep	Sleep Apnea
History of prematurity and early respiratory infections	Personal and Family History of Respiratory Symptoms/Diseases (Adult and Child)
Pediatric lung diseases, newborn
Risk factors (past and present)
Exposures	Cotinine
Geographic history of patient (histoplasmosis)
Institutional residence (prisoner, nursing home)
Family history (see Personal history of conditions and symptoms)	Personal and Family History of Respiratory Symptoms/Diseases (Adult and Child)
Biologic and physiologic assessments
Infectious organisms (pneumococci, staphylococci, gram-negative bacilli
Opportunistic microbes (candida, aspergillus, cytomegalovirus)
Manifestations (dyspnea, cough, hemoptysis [blood in sputum], abnormal production of sputum, cyanosis [bluish discoloration of skin], thoracic pain [pleuritic, pulmonary, chest wall, cardiac], fever)
Blood dyscrasia
Lipoid pneumonia caused by nose drops
Klebsiella pneumonia in chronic alcoholics
Pulmonary function tests (PFT) for: obstructive disease of the airways; restrictive lung disease; alveolar hypoventilation due to malfunctioning of the chest bellows or control mechanisms; and obliterative vascular disease.	Original element broken into three specific measures: Spirometry, Peak Expiratory Flow Rate (PEFR), and Bronchodilator Responsiveness (BDR)
Pulmonary embolism
Treatments and procedures (past and present)
Radiologic evaluation (chest X-ray or CXR)
Drug treatments
	Chest Computed Tomography (CT)
	Cotinine
	Immunoglobulin E (Total and Specific)
	Pulse Oximetry (rest)
	Pulse Oximetry (exercise)
	Included as a supplemental measure
	Arterial Blood Gas (ABG)
	Exercise Capacity/Six-Minute Walk Test
	Allergy Skin Prick Test (Supplmental)

Working Group Roster:

WG Members:

Edwin (Ed) K. Silverman, MD, PhD, Chair Brigham and Women's Hospital Harvard Medical School (Channing Laboratory) Boston, MA	F. Sessions Cole, III, MD Washington University in St. Louis School of Medicine, Department of Pediatrics St. Louis, MO
Jason D. Christie, MD University of Pennsylvania Philadelphia, PA	Gang Dong, MD, PhD National Institute of Allergy and Infectious Diseases (NIAID) Division of Allergy, Immunology, and Transplantation (DAIT) Bethesda, MD
James (Jim) E. Loyd, MD Vanderbilt University School of Medicine (Division of Pulmonology) Nashville, TN	Geoffrey McLennan, MB, BS, FRACP, PhD University of Iowa Iowa City, IA
Gail G. Weinmann, MD National Heart, Lung, and Blood Institute (NHLBI) Division of Lung Diseases Bethesda, MD

SC Liaison, WG Manager and WG Supervisor:

Terri H. Beaty, PhD, SC Liaison Johns Hopkins University School of Public Health Baltimore, MD	Jennifer Lyden, MPH, WG Manager RTI International Statistics and Epidemiology Division Research Triangle Park, NC
Lisa Strader, MPH, WG Supervisor RTI International Research Triangle Park, NC

Expert Review Panel 6 - Respiratory domain:

ERP Members:

David M. Mannino, MD
University of Kentucky College of Public Health
Lexington, KY

Stephanie D. Davis, MD
Indiana University School of Medicine
Indianapolis, IN

SC Liaison, ERP Manager and ERP Supervisor:

Daniel R. Masys, MD, FACMI, SC Liaison University of Washington School of Medicine Seattle, WA	Stacie White, BS, ERP Manager RTI International Research Triangle Park, NC
Michael Phillips, MS, ERP Supervisor RTI International Research Triangle Park, NC

Respiratory Supplemental Information includes:

Additional Information for Respiratory Measures:

Showing 1 to 14 of 14 protocols

Select	Measure Name	Protocols
	Arterial Blood Gas (ABG)	Arterial Blood Gas (ABG) Arterial Blood Gas (ABG)
	Bronchodilator Responsiveness (BDR)	Bronchodilator Responsiveness (BDR)
	Chest Computed Tomography (CT)	Chest Computed Tomography (CT) Chest Computed Tomography (CT)
	Exercise Capacity/Six-Minute Walk Test	Exercise Capacity/Six-Minute Walk Test Exercise Capacity/Six-Minute Walk Test
	Immunoglobulin E (Total and Specific)	Immunoglobulin E (Total and Specific)
	Peak Expiratory Flow Rate (PEFR)	Peak Expiratory Flow Rate (PEFR)
	Personal and Family History of Respiratory Symptoms/Diseases	Personal and Family History of Respiratory Symptoms/Diseases - Adult Personal and Family History of Respiratory Symptoms/Diseases - Child
	Pulse Oximetry (Exercise)	Pulse Oximetry (Exercise)
	Pulse Oximetry (Rest)	Pulse Oximetry (Rest) Pulse Oximetry (Rest)
	Quality of Life as Affected by Respiratory Disease	Quality of Life as Affected by Respiratory Disease
	Respiratory Rate	Respiratory Rate - Infant Respiratory Rate - Child Respiratory Rate - Adult Respiratory Rate - Infant
	Sleep Apnea	Sleep Apnea - Adult Sleep Apnea - Child
	Spirometry	Spirometry - Adult Spirometry - Child
	Biomarker of exposure to nicotine-containing products	Biomarker of exposure to nicotine-containing products - Urine Biomarker of exposure to nicotine-containing products - Saliva Biomarker of exposure to nicotine-containing products - Serum Biomarker of exposure to nicotine-containing products - Urine Biomarker of exposure to nicotine-containing products - Saliva Biomarker of exposure to nicotine-containing products - Serum Biomarker of exposure to nicotine-containing products - Urine Biomarker of exposure to nicotine-containing products - Saliva Biomarker of exposure to nicotine-containing products - Serum

Showing 1 to 14 of 14 protocols

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Research Domain - Respiratory

Research Domains:

Arterial Blood Gas (ABG) Davis, M.D., et al. AARC clinical practice guideline: Blood gas analysis and hemoximetry. Respir Care, 2013

#090202

#091708

Biomarker of exposure to nicotine-containing products - Serum Bernert JT, et al. Interlaboratory comparability of serum cotinine measurements at smoker and nonsmoker concentration levels: a round-robin study. Nicotine Tob Res, 2009

#091709

Biomarker of exposure to nicotine-containing products - Urine Wang L, et al. Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine. CANCER EPIDEM BIOMAR, 2018

#091707

Bronchodilator Responsiveness (BDR) National Institutes of Health (NIH), COPDGene Study Clinical Center Manual of Procedures, 2009

#090301

Chest Computed Tomography (CT) Genetic Epidemiology of COPD Clinical Center Manual of Procedures, 2014

#090402

Exercise Capacity/Six-Minute Walk Test Six-Minute Walk Test (6MWT)

#090602

Immunoglobulin E (Total and Specific) Williams, P. B., et al, Analytic precision and accuracy of commercial immunoassays for specific IgE: Establishing a standard, J ALLERGY CLIN IMMUN, 2000

#090701

Peak Expiratory Flow Rate (PEFR) Miller, M. R., et al, Standardization of spirometry. Series “ATS/ERS task force: Standardization of lung function testing.”, EUR RESPIR J, 2005

#090801

Personal and Family History of Respiratory Symptoms/Diseases - Adult American Thoracic Society-Division of Lung Diseases Questionnaire (ATS-DLD 78) & Genetic Epidemiology of COPD Study (COPDGene)

#090901

Personal and Family History of Respiratory Symptoms/Diseases - Child International Study of Asthma and Allergies in Childhood (ISAAC) Manual

#090902

Pulse Oximetry (Exercise) AARC Clinical Practice Guideline: Exercise Testing for Evaluation of Hypoxemia and/or Desaturation: revision & update. Resp Care, 2001

#091001

Pulse Oximetry (Rest) World Health Organization (WHO), Pulse oximetry training manual, 2011

#091102

Quality of Life as Affected by Respiratory Disease St. Georges Respiratory Questionnaire (SGRQ)

#091301

Respiratory Rate - Adult Potter, P. A., et al. Fundamentals of Nursing, 1985

#091403

Respiratory Rate - Child Wallis, L. A., Healy, et al, Age related reference ranges for respiration rate and heart rate from 4 to 16 years, ARCH DIS CHILD, 2005

#091402

Respiratory Rate - Infant Fleming, S, et al. Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: A systemic review of observational studies. Lancer, 2011

#091404

Sleep Apnea - Adult Berlin Questionnaire

#091501

Sleep Apnea - Child The Pediatric Sleep Questionnaire (PSQ), Version 070424

#091502

Spirometry - Adult Miller, M. R., et al, Standardization of spirometry. Series “ATS/ERS task force: Standardization of lung function testing.”, EUR RESPIR J, 2005

#091601

Spirometry - Child Beydon, N., et al, An official American Thoracic Society/European Respiratory Society statement: Pulmonary function testing in preschool children, AM J RESP CRIT CARE, 2007

#091602

Release Date:

Scope of Domain:

Working Group Roster:

Expert Review Panel 6 - Respiratory domain:

Respiratory Supplemental Information includes:

Additional Information for Respiratory Measures:

Arterial Blood Gas (ABG)
Davis, M.D., et al. AARC clinical practice guideline: Blood gas analysis and hemoximetry. Respir Care, 2013

Biomarker of exposure to nicotine-containing products - Serum
Bernert JT, et al. Interlaboratory comparability of serum cotinine measurements at smoker and nonsmoker concentration levels: a round-robin study. Nicotine Tob Res, 2009

Biomarker of exposure to nicotine-containing products - Urine
Wang L, et al. Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine. CANCER EPIDEM BIOMAR, 2018

Bronchodilator Responsiveness (BDR)
National Institutes of Health (NIH), COPDGene Study Clinical Center Manual of Procedures, 2009

Chest Computed Tomography (CT)
Genetic Epidemiology of COPD Clinical Center Manual of Procedures, 2014

Exercise Capacity/Six-Minute Walk Test
Six-Minute Walk Test (6MWT)

Immunoglobulin E (Total and Specific)
Williams, P. B., et al, Analytic precision and accuracy of commercial immunoassays for specific IgE: Establishing a standard, J ALLERGY CLIN IMMUN, 2000

Peak Expiratory Flow Rate (PEFR)
Miller, M. R., et al, Standardization of spirometry. Series “ATS/ERS task force: Standardization of lung function testing.”, EUR RESPIR J, 2005

Personal and Family History of Respiratory Symptoms/Diseases - Adult
American Thoracic Society-Division of Lung Diseases Questionnaire (ATS-DLD 78) & Genetic Epidemiology of COPD Study (COPDGene)

Personal and Family History of Respiratory Symptoms/Diseases - Child
International Study of Asthma and Allergies in Childhood (ISAAC) Manual

Pulse Oximetry (Exercise)
AARC Clinical Practice Guideline: Exercise Testing for Evaluation of Hypoxemia and/or Desaturation: revision & update. Resp Care, 2001

Pulse Oximetry (Rest)
World Health Organization (WHO), Pulse oximetry training manual, 2011

Quality of Life as Affected by Respiratory Disease
St. Georges Respiratory Questionnaire (SGRQ)

Respiratory Rate - Adult
Potter, P. A., et al. Fundamentals of Nursing, 1985

Respiratory Rate - Child
Wallis, L. A., Healy, et al, Age related reference ranges for respiration rate and heart rate from 4 to 16 years, ARCH DIS CHILD, 2005

Respiratory Rate - Infant
Fleming, S, et al. Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: A systemic review of observational studies. Lancer, 2011

Sleep Apnea - Adult
Berlin Questionnaire

Sleep Apnea - Child
The Pediatric Sleep Questionnaire (PSQ), Version 070424

Spirometry - Adult
Miller, M. R., et al, Standardization of spirometry. Series “ATS/ERS task force: Standardization of lung function testing.”, EUR RESPIR J, 2005

Spirometry - Child
Beydon, N., et al, An official American Thoracic Society/European Respiratory Society statement: Pulmonary function testing in preschool children, AM J RESP CRIT CARE, 2007