Criteria for Selecting Measures

The PhenX Steering Committee suggested a number of criteria to guide the selection of the measures to be included in the PhenX Toolkit.

The measures should be:

• Clearly defined
• Well established
• Broadly applicable and generally accepted
• Low burden to participants and investigators
• Broadly validated and demonstrated utility
• Reproducible
• Specific
• Reliable
• Standard measurement protocols exist

Additional criteria for selecting the measures include:

• Crosscutting relevance for population groups as well as diseases and conditions
• Prior use in GWAS
• Use in major reference study (e.g., NHANES)
• Open-source software and nonproprietary instruments preferred
• Brevity
• Expectation of acceptance by the research community