Criteria for Selecting PhenX Protocols

• The protocols should be
• Clearly defined
• Well established
• Use in major reference study (e.g., NHANES) or consortium (e.g., EMERGE)
• Standard measurement protocols exist
• Broadly validated and demonstrated utility
• Reproducible
• Reliable
• Low burden to participants and investigators
• Whenever possible
• Cross-cutting relevance for population groups as well as diseases and conditions
• Prior use in omics research
• Open-source software and nonproprietary instruments preferred