Criteria for Selecting Measures
The PhenX Steering Committee suggested a number of criteria to guide the selection of the measures to be included in the PhenX Toolkit.
The measures should be:
- Clearly defined
- Well established
- Broadly applicable and generally accepted
- Low burden to participants and investigators
- Broadly validated and demonstrated utility
- Reproducible
- Specific
- Reliable
- Standard measurement protocols exist
Additional criteria for selecting the measures include:
- Crosscutting relevance for population groups as well as diseases and conditions
- Prior use in GWAS
- Use in major reference study (e.g., NHANES)
- Open-source software and nonproprietary instruments preferred
- Brevity
- Expectation of acceptance by the research community