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Browse » Domains » Infectious Diseases and Immunity » Assay for Human Leukocyte Antigen (HLA) Genotyping

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Measure: Assay for Human Leukocyte Antigen (HLA) Genotyping   #160600

Definition: A bioassay to obtain the specific allelic genotypes of several of the human leukocyte antigens, whose genes reside on chromosome 6p within the Major Histocompatibility Region (MHC).

Purpose: The measure determines the alleles/single nucleotide polymorphisms that are present in the human leukocyte antigen regions of chromosome 6 to assess the major histocompatability system. The genetic variation within the human leukocyte antigen region determines the person's immune response and has been tied to specific autoimmune disorders such as Graves' disease and Hashimoto's thyroiditis, as well as other diseases such as multiple sclerosis, ankylosing spondylitis, and type 1 diabetes. This assay is similar to the genotyping performed in genome wide association studies but captures much more of the genetic variation within the human leukocyte antigen region than would be covered with "tag" single nucleotide polymorphisms.

Protocols:

Keywords: Infectious disease, Human leukocyte antigen, HLA, Type 1 Diabetes Genetics Consortium, Infectious Diseases and Immunity

Measure Release Date: November 12, 2010

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