Protocol - Bone Age

Personnel and Training Required

A radiologist professionally trained to evaluate bone age via the Tanner and Whitehouse Method.

Equipment Needs

X-ray machine

Requirements

Requirement Category	Required
Major equipment	Yes
Specialized training	Yes
Specialized requirements for biospecimen collection	No
Average time of greater than 15 minutes in an unaffected individual	Yes

Mode of Administration

Noninvasive radiologic assessment

Lifestage

Toddler, Child, Adolescent

Participants

Ages 2-18 years old

Selection Rationale

The Rare Genetic Conditions Working Group selected the Tanner and Whitehouse Method because it is the most reproducible and, potentially, the most accurate procedure to determine bone age.

Language

English

Standards

Standard	Name	ID	Source
Human Phenotype Ontology	Delayed bone age	HP:0002750	HPO
Human Phenotype Ontology	Dysharmonic bone age	HP:0200000	HPO
Human Phenotype Ontology	Accelerated skeletal maturation	HP:0005616	HPO
caDSR Form	PhenX PX220301 - Bone Age	6201642	caDSR Form
Logical Observation Identifiers Names and Codes (LOINC)	PhenX - bone age protocol 220301	93149-3	LOINC

Derived Variables

None

Process and Review

This section will be completed when reviewed by an Expert Review Panel.

Protocol Name from Source

Tanner and Whitehouse Method (TW2)

Source

Online tool for assessment:

Jantschi, L., & Bolboaca, S. (2003). Tanner and Whitehouse Test. Available at vl.academicdirect.org/medical_informatics/bone_age/v1.0/

Original source:

Tanner, J. M., Whitehouse, R. H., Marshall, W. A., Healey, M. J. R., Goldstein, H. (1976). Assessment of skeletal maturity and prediction of adult height (TW2 method). London: Academic Press.

General References

Bull, R. K., Edwards, P. D., Kemp, P.M., Fry, S., & Hughes, I.A. (1999). Bone age assessment: A large scale comparison of the Greulich and Pyle, and Tanner and Whitehouse (TW2) methods. Archives of Disease in Childhood, 81, 172-173.

Ostojic, S. M. (2013). Prediction of adult height by Tanner-Whitehouse method in young Caucasian male athletes. QJM, 106, 341-345.

Protocol ID

220301

Variables

Export Variables

Variable Name	Variable ID	Variable Description	dbGaP Mapping
PX220301_Bone_Age_Capitate
	PX220301140000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_Diagnostic
	PX220301240000	Diagnoistic Code	N/A
PX220301_Bone_Age_DistalPhalanx_Thumb
	PX220301110000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_Distal_Phalanx_FifthFinger
	PX220301130000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_Distal_Phalanx_ThirdFinger
	PX220301120000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_Fifth_Metacarpal
	PX220301050000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_First_Metacarpal
	PX220301030000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_Hamate
	PX220301150000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_Lunate
	PX220301170000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_Middle_Plananx_FifthFinger
	PX220301100000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_Middle_Plananx_ThirdFinger
	PX220301090000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_Patient_Address
	PX220301220000	Patient's Address	N/A
PX220301_Bone_Age_Patient_Age
	PX220301270000	Patient Age in Years and Months	Variable Mapping
PX220301_Bone_Age_Patient_Gender
	PX220301250000	Patient gender	Variable Mapping
PX220301_Bone_Age_Patient_Height
	PX220301280000	Patient Height	N/A
PX220301_Bone_Age_Patient_Name
	PX220301210000	Patient Full Name	N/A
PX220301_Bone_Age_Patient_Weight
	PX220301260000	Patient Weight	Variable Mapping
PX220301_Bone_Age_ProximalPhalanxa_Fifth_Finger
	PX220301080000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_ProximalPhalanxa_Third_Finger
	PX220301070000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_ProximalPhalanxa_Thumb
	PX220301060000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_Radius
	PX220301010000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_Scaphoid
	PX220301180000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_Third_Metacarpal
	PX220301040000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_Trapexoid
	PX220301200000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_Trapezium
	PX220301190000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_Triquetral
	PX220301160000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_Ulna
	PX220301020000	findings associated with each of the more following 20 regions of interest (ROI) of the left hand as seen on x-ray show less	N/A
PX220301_Bone_Age_Xray_Date
	PX220301230000	Date of X-Ray	N/A

Rare Genetic Conditions

Measure Name

Bone Age

Release Date

April 30, 2015

Definition

A clinical assessment of the bone growth of the left hand via an x-ray.

Purpose

Bone age is an assessment of skeletal maturity and can be compared with chronological age to determine if there are abnormalities in development.

Keywords

bone, age, bone age, x-ray, radiologist, Tanner and Whitehouse Method, TW2, growth, height, Developmental Delay, adolescent, short stature, endocrine disorders, bone age assessment, BAA, hormone therapy, skeletal maturity

Measure Protocols

Protocol ID	Protocol Name
220301	Bone Age

Publications

There are no publications listed for this protocol.