Protocol - Family History of Heart Attack
This measure assesses if the respondents biological parents, siblings, and children have had a heart attack.
If the respondent answers "yes" to the first question, then the interviewer will proceed to the next question, which asks about history of heart attack for specific biological relatives.
For these questions, please think about full-blooded relatives only. Do not think about half-sisters or half-brothers, or relatives who are related to you by marriage or adoption. Full-blooded sisters and brothers are those who had the same two parents as you. If you are adopted or are not sure about some relatives health history, please include any family history that you know about.
1. Did your mother, father, full-blooded sisters, full-blooded brothers, daughters, or sons ever have a heart attack or myocardial infarction?
9[ ]Dont Know
If Yes, continue to 2. If No or Dont Know, end of protocol.
Please answer the following questions for each of your relatives, starting with those who had a heart attack. If you do not have a full-blooded sister, full-blooded brother, daughter, or son, leave the spaces blank.
2. Did this relative have a heart attack?
How old was he or she when the first heart attack occurred?
|Dont know if he or she had a heart attack |
|Less than 55 |
|65 or older |
|Dont know age |
The definition of a positive family history of coronary heart disease is father, brother, or son with coronary disease onset at age <55 years and mother, sister, or daughter with coronary disease onset at age <65 years.
Personnel and Training Required
An interviewer who is trained to conduct personal interviews with individuals from the general population is required. The interviewer must be trained and found to be competent (i.e., tested by an expert) at the completion of personal interviews.* The interviewer should be trained to prompt respondents further if a "dont know" response is provided.
* There are multiple modes to administer this question (e.g., paper-and-pencil and computer-assisted interviews).
|Specialized requirements for biospecimen collection||No|
|Average time of greater than 15 minutes in an unaffected individual||No|
Mode of Administration
Women ages 50–79 years old
Note: This protocol has been reliably used with women ages 50–79 years old. However, the Cardiovascular Working Group suggests that the same methodology be used for men and women below age 50 years old.
This protocol was selected because it obtains the age at which the heart attack occurred, which is a vital part of identifying a positive family history. It was also used on a major U.S. health study and captures a thorough picture of family history through the inclusion of several family member categories (i.e., mother, father, sisters, brothers, daughters, sons).
Chinese, English, Other languages available at source
|Logical Observation Identifiers Names and Codes (LOINC)||Fam hx heart attack proto||62390-0||LOINC|
|Human Phenotype Ontology||Myocardial infarction||HP:0001658||HPO|
|caDSR Form||PhenX PX040101 - Family History Of Heart Attack||5822387||caDSR Form|
Process and Review
Protocol Name from Source
Womens Health Initiative (WHI), Family History Questionnaire, Version 3
U.S. Department of Health and Human Services. National Institutes of Health. National Heart, Lung and Blood Institute. Womens Health Initiative (WHI). Form 32&emdash;Family History Questionnaire. Version 3. Page 4. Question 8 (source for questions 1 and 2 in Protocol Text).
National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III Guidelines. http://www.nhlbi.nih.gov/guidelines/cholesterol/atp3full.pdf (source for Diagnostic Criteria).
|Variable Name||Variable ID||Variable Description||dbGaP Mapping|
|PX040101020600||Did your brother have a heart attack?||Variable Mapping|
|PX040101020700||Did your brother have a heart attack?||N/A|
|PX040101020800||Did your brother have a heart attack?||N/A|
|PX040101020900||Did your daughter have a heart attack?||Variable Mapping|
|PX040101021000||Did your daughter have a heart attack?||N/A|
|PX040101010000||Did your mother, father, full-blooded more||Variable Mapping|
|PX040101020200||Did your father have a heart attack?||Variable Mapping|
|PX040101020100||Did your mother have a heart attack?||Variable Mapping|
|PX040101020300||Did your sister have a heart attack?||Variable Mapping|
|PX040101020400||Did your sister have a heart attack?||N/A|
|PX040101020500||Did your sister have a heart attack?||N/A|
|PX040101021100||Did your son have a heart attack?||Variable Mapping|
|PX040101021200||Did your son have a heart attack?||N/A|
Family History of Heart Attack
September 9, 2009
Measure to assess whether respondent's biological parents, siblings, and children have had a heart attack.
Family history is used to assess the presence and age of onset of heart attack in all first-degree relatives. A positive family history for heart attack in a first-degree relative (parent, siblings, or offspring) at a relatively young age is a major risk factor for coronary heart disease.
family history of heart attack, Cardiovascular, Womens Health Initiative, WHI, National Cholesterol Education Program, NCEP, Heart attack, myocardial infarction, coronary heart disease, CHD, cardiovascular disease, Cardiovascular, Family History, family history of heart attack
|Protocol ID||Protocol Name|
|40101||Family History of Heart Attack|
Pattaro, C., et al. (2015) The Cooperative Health Research in South Tyrol (CHRIS) study: rationale, objectives, and preliminary results. J Transl Med. 2015 November; 13: 348. doi: 10.1186/s12967-015-0704-9