Protocol - Family History of Substance Use Problems - Alcohol
Description
The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV) is a fully structured diagnostic interview designed to assess alcohol, drug, and mental disorders according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), diagnostic criteria in both clinical and general populations. Section 2D of AUDADIS-IV assesses a respondent’s family history of drinking problems or alcoholism (generally defined).
Specific Instructions
This measure was previously included in the Alcohol, Tobacco, and Other Substances (ATOS) Supplemental Information as "Alcohol - Family history of alcohol abuse" and was promoted to the Toolkit on February 24, 2012 by the Working Group on Assessment of Substance Use and Substance Use Disorders.
The Substance Abuse and Addiction Working Group acknowledges that the following questions may gather sensitive information relating to the use of substances and/or illegal conduct. If the information is released, it might be damaging to an individual’s employability, lead to social stigmatization, or lead to other consequences.
Most researchers assure confidentiality as part of their informed consent process, as required by their institutional review boards. Further assurance of confidentiality may be obtained by applying to the National Institutes of Health (NIH) for a Certificate of Confidentiality, which helps researchers protect the privacy of human research participants. The procedures for the Certificate of Confidentiality can be found at the Grants Policy website of NIH: http://grants1.nih.gov/grants/policy/coc/index.htm.
Availability
Protocol
Now I would like to ask you some questions about whether any of your relatives, regardless of whether or not they are now living, have EVER been alcoholics or problem drinkers. By alcoholic or problem drinker, I mean a person who has physical or emotional problems because of drinking (PAUSE); problems with a spouse/partner, family, or friends because of drinking (PAUSE); problems at work or school because of drinking (PAUSE); problems with the police because of drinking-like drunk driving (PAUSE) or a person who seems to spend a lot of time drinking or being hung over. (Repeat definition frequently.)
1. Has/Was your blood or natural father been an alcoholic or problem drinker at ANY time in his life?
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
2. Has/Was your blood or natural mother been an alcoholic or problem drinker at ANY time in her life?
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
3a. How many full brothers have you had who lived to be at least 10 years old, including those who are still living? By full brothers, I mean brothers who have the same natural mother AND the same natural father as you do.
___Number
0 [ ] None
Don’t Know/Refused
If Question 3a is None, Don’t Know, or Refused, then skip to Question 4a.
If Question 3a is 1, then respondent is asked Question 3b.
If Question 3a is >1, then respondent is asked Question 3c.
3b. Was your full brother an alcoholic or problem drinker at ANY time in his life?
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
3c. How many of your full brothers are now, or were in the past, alcoholics or problem drinkers?
___Number
Don’t Know/Refused
4a. How many full sisters have you had who lived to be at least 10 years old, including those who are still living? By full sisters, I mean sisters who have the same natural mother AND the same natural father as you do.
___Number
0 [ ] None
Don’t Know/Refused
If Question 4a is None, Don’t Know, or Refused, then skip to Question 5a.
If Question 4a is 1, then respondent is asked Question 4b.
If Question 4a is >1, then respondent is asked Question 4c.
4b. Was your full sister an alcoholic or problem drinker at ANY time in her life?
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
4c. How many of your full sisters are now, or were in the past, alcoholics or problem drinkers?
___Number
Don’t Know/Refused
5a. How many natural sons have you had who lived to be at least 10 years old, including those who are still living? By natural, I mean those who you (biologically fathered/gave birth to.)
___Number
0 [ ] None
Don’t Know/Refused
If Question 5a is None, Don’t Know, or Refused, then skip to Question 6a.
If Question 5a is 1, then respondent is asked Question 5b.
If Question 5a is >1, then respondent is asked Question 5c.
5b. Was your natural son an alcoholic or problem drinker at ANY time in his life?
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
5c. How many of your natural sons are now, or were in the past, alcoholics or problem drinkers?
___Number
Don’t Know/Refused
6a. How many natural daughters have you had who lived to be at least 10 years old, including those who are still living? By natural, I mean those who you (biologically fathered/gave birth to.)
___Number
0 [ ] None
Don’t Know/Refused
If Question 6a is None, Don’t Know, or Refused, then skip to Question 7a.
If Question 6a is 1, then respondent is asked Question 6b.
If Question 6a is >1, then respondent is asked Question 6c.
6b. Was your natural daughter an alcoholic or problem drinker at ANY time in her life?
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
6c. How many of your natural daughters are now, or were in the past, alcoholics or problem drinkers?
___Number
Don’t Know/Refused
7a. How many full brothers did your natural father have who lived to be at least 10 years old, including those who are still alive? By full brothers, I mean those who had the SAME TWO natural or blood parents as your father.
___Number
0 [ ] None
Don’t Know/Refused
If Question 7a is None, Don’t Know, or Refused, then skip to Question 8a.
If Question 7a is 1, then respondent is asked Question 7b.
If Question 7a is >1, then respondent is asked Question 7c.
7b. Was your natural father’s full brother an alcoholic or problem drinker at ANY time in his life?
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
7c. How many of your natural father’s full brothers are now, or were in the past, alcoholics or problem drinkers?
___Number
Don’t Know/Refused
8a. How many full sisters did your natural father have who lived to be at least 10 years old, including those who are still living? By full sisters, I mean those who had the SAME TWO natural or blood parents as your father.
___Number
0 [ ] None
Don’t Know/Refused
If Question 8a is None, Don’t Know, or Refused, then skip to Question 9a.
If Question 8a is 1, then respondent is asked Question 8b.
If Question 8a is >1, then respondent is asked Question 8c.
8b. Was your natural father’s full sister an alcoholic or problem drinker at ANY time in her life?
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
8c. How many of your natural father’s full sisters are now, or were in the past, alcoholics or problem drinkers?
___Number
Don’t Know/Refused
9a. How many full brothers did your natural mother have who lived to be at least 10 years old, including those who are still living? By full brothers, I mean those who had the SAME TWO natural or blood parents as your mother.
___Number
0 [ ] None
Don’t Know/Refused
If Question 9a is None, Don’t Know, or Refused, then skip to Question 10a.
If Question 9a is 1, then respondent is asked Question 9b.
If Question 9a is >1, then respondent is asked Question 9c.
9b. Was your natural mother’s full brother an alcoholic or problem drinker at ANY time in his life?
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
9c. How many of your natural mother’s full brothers are now, or were in the past, alcoholics or problem drinkers?
___Number
Don’t Know/Refused
10a. How many full sisters did your natural mother have who lived to be at least 10 years old, including those who are still alive? By full sisters, I mean those who had the SAME TWO natural or blood parents as your mother.
___Number
0 [ ] None
Don’t Know/Refused
If Question 10a is None, Don’t Know, or Refused, then skip to Question 11.
If Question 10a is 1, then respondent is asked Question 10b.
If Question 10a is >1, then respondent is asked Question 10b.
10b. Was your natural mother’s full sister an alcoholic or problem drinker at ANY time in her life?
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
10c. How many of your natural mother’s full brothers are now, or were in the past, alcoholics or problem drinkers?
___Number
Don’t Know/Refused
11. Was your natural grandfather on your father’s side an alcoholic or problem drinker at ANY time in his life? By natural grandfather on your father’s side, I mean your father’s natural or blood father.
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
12. Was your natural grandmother on your father’s side an alcoholic or problem drinker at ANY time in her life? By natural grandmother on your father’s side, I mean your father’s natural or blood mother.
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
13a. Was your natural grandfather on your mother’s side an alcoholic or problem drinker at ANY time in his life? By natural grandfather on your mother’s side, I mean your mother’s natural or blood father.
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
13b. Was your natural grandmother on your mother’s side an alcoholic or problem drinker at ANY time in her life? By natural grandmother on your mother’s side, I mean your mother’s natural or blood mother.
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
If respondent has never been married, then skip to Question 17.
Otherwise, respondent is asked Question 14
14. Were you EVER married to an alcoholic or problem drinker?
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
If Question 14 is No, Don’t Know, or Refused, then skip to Question 17.
If Question 14 is Yes, continue with Question 15.
15. Is that your current (husband/wife)?
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
If Question 15 is No, Don’t Know, or Refused, then skip to Question 17.
16. Would you say that (he/she) is an alcoholic or problem drinker at this time?
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
17. Did you EVER live with someone as if you were married?
Reiterate that this person is not a spouse.
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
If Question 17 is No, Don’t Know, or Refused, then end section.
If Question 17 is Yes, then respondent is asked Questions 18-19.
18. Did you EVER live as if married with someone who was an alcoholic or problem drinker?
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
19. Is that the person you live with now?
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
If Question 19 is No, Don’t Know, or Refused, then end section.
20. Would you say that (he/she) is an alcoholic or problem drinker at this time?
1 [ ] Yes
2 [ ] No
Don’t Know/Refused
Personnel and Training Required
The interviewer must be trained to conduct personal interviews with individuals from the general population. The interviewer must be trained and found to be competent (i.e., tested by an expert) in the completion of personal interviews. The interviewer should be trained to prompt respondents further if a "don’t know" response is provided.
Equipment Needs
While the Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV) was developed for administration by computer, the literature suggests that these questions can be administered in a noncomputerized format. Hasin et al. (1997) and Grant et al. (1995) used AUDADIS-IV in paper-and-pencil format, while Grant et al. (2003) obtained data with the computerized format. If the questions are administered via paper and pencil, it is essential that the proper skip pattern is followed.
Requirements
| Requirement Category | Required |
|---|---|
| Major equipment | No |
| Specialized training | No |
| Specialized requirements for biospecimen collection | No |
| Average time of greater than 15 minutes in an unaffected individual | No |
Mode of Administration
Self-administered or interviewer-administered questionnaire
Lifestage
Adult, Senior
Participants
Adults aged 18 years and older
Selection Rationale
The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV) was chosen because it has been used in a large epidemiologic study, the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), containing adults with a wide age range and different ethnicities. The questions from this protocol have been validated, and they are low burden. While originally developed as interviewer-administered, AUDADIS has been validated in several modes of administration.
Unlike other validated instruments that probe only first-degree relatives, AUDADIS-IV captures first- and second-degree relatives as well as spouses/partners.
Language
English
Standards
| Standard | Name | ID | Source |
|---|---|---|---|
| Human Phenotype Ontology | Alcoholism | HP:0030955 | HPO |
| caDSR Form | PhenX PX510101 - Family History Of Substance Use Problems Alcohol | 6208311 | caDSR Form |
Derived Variables
None
Process and Review
The Expert Review Panel #3 (ERP 3) reviewed the measures in Alcohol, Tobacco and Other Substances, and Substance Abuse and Addiction domains.
Guidance from ERP 3 includes:
• No significant changes to measure
Back-compatible: NA no changes to Data Dictionary
Protocol Name from Source
Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV)
Source
Grant, B. F., Dawson, D. A., Stinson, F. S., Chou, P. S., Kay, W., & Pickering, R. (2003). The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV): Reliability of alcohol consumption, tobacco use, family history of depression and psychiatric diagnostic modules in a general population sample. Drug and Alcohol Dependence, 71(1), 7-16.
National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Epidemiologic Survey on Alcohol and Related Conditions, Wave 1 (NESARC-WAVE 1). Alcohol Use Disorder and Associated Disabilities Interview Schedule - Diagnostic and Statistical Manual of Mental Disorders. Fourth Edition Version (AUDADIS-IV). Section 2D. Questions 1-13b.
General References
Grant, B. F., Dawson, D. A., & Hasin, D. S. (2001). The Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV Version. Bethesda, MD: National Institute on Alcohol Abuse and Alcoholism.
Grant, B. F., Dawson, D. A., Stinson, F. S., Chou, P. S., Kay, W., & Pickering, R. (2003). The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV): Reliability of alcohol consumption, tobacco use, family history of depression and psychiatric diagnostic modules in a general population sample. Drug and Alcohol Dependence, 71(1), 7-16.
Grant, B. F., Harford, T. C., Dawson, D. A., Chou, P. S., & Pickering, R. P. (1995). The Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS): Reliability of alcohol and drug modules in a general population sample. Drug and Alcohol Dependence, 39(1), 37-44.
Hasin, D., Carpenter, K. M., McCloud, S., Smith, M., & Grant, B. F. (1997). The Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS): Reliability of alcohol and drug modules in a clinical sample. Drug and Alcohol Dependence, 44(2-3):133-141.
Protocol ID
510101
Variables
Export Variables| Variable Name | Variable ID | Variable Description | dbGaP Mapping | |
|---|---|---|---|---|
| PX510101_Brother_Alcoholic_Problem_Drinker | ||||
| PX510101030200 | Was your full brother an alcoholic or more | N/A | ||
| PX510101_Current_Spouse_Alcoholic | ||||
| PX510101150000 | Is that your current (husband/wife)? | N/A | ||
| PX510101_Current_Spouse_Alcoholic_Now | ||||
| PX510101160000 | Would you say that (he/she) is an alcoholic more | N/A | ||
| PX510101_Daughter_Alcoholic_Problem_Drinker | ||||
| PX510101060200 | Was your natural daughter an alcoholic or more | N/A | ||
| PX510101_Father_Alcoholic_Problem_Drinker | ||||
| PX510101010000 | Has/Was your blood or natural father been an more | Variable Mapping | ||
| PX510101_Live_With_Someone | ||||
| PX510101170000 | Did you EVER live with someone as if you more | N/A | ||
| PX510101_Live_With_Someone_Alcoholic | ||||
| PX510101180000 | Did you EVER live as if married with someone more | N/A | ||
| PX510101_Live_With_Someone_Alcoholic_Currently | ||||
| PX510101200000 | Would you say that (he/she) is an alcoholic more | N/A | ||
| PX510101_Live_With_Someone_Now_Alcoholic | ||||
| PX510101190000 | Is that the person you live with now? | N/A | ||
| PX510101_Married_To_Alcoholic | ||||
| PX510101140000 | Were you EVER married to an alcoholic or more | N/A | ||
| PX510101_Maternal_Aunt_Alcoholic_Problem_Drinker | ||||
| PX510101100200 | Was your natural mother's full sister an more | N/A | ||
| PX510101_Maternal_Grandfather_Alcoholic | ||||
| PX510101130100 | Was your natural grandfather on your more | N/A | ||
| PX510101_Maternal_Grandmother_Alcoholic | ||||
| PX510101130200 | Was your natural grandmother on your more | N/A | ||
| PX510101_Maternal_Uncle_Alcoholic_Problem_Drinker | ||||
| PX510101090200 | Was your natural mother's full brother an more | N/A | ||
| PX510101_Mother_Alcoholic_Problem_Drinker | ||||
| PX510101020000 | Has/Was your blood or natural mother been an more | Variable Mapping | ||
| PX510101_Number_Brothers_Alcoholic_Problem_Drinker | ||||
| PX510101030300 | How many of your full brothers are now, or more | N/A | ||
| PX510101_Number_Daughters_Alcoholic_Problem_Drinker | ||||
| PX510101060300 | How many of your natural daughters are now, more | N/A | ||
| PX510101_Number_Full_Brothers | ||||
| PX510101030100 | How many full brothers have you had who more | Variable Mapping | ||
| PX510101_Number_Full_Sisters | ||||
| PX510101040100 | How many full sisters have you had who lived more | N/A | ||
| PX510101_Number_Maternal_Aunts_Alcoholic | ||||
| PX510101100300 | How many of your natural mother's full more | N/A | ||
| PX510101_Number_Maternal_Uncles_Alcoholic | ||||
| PX510101090300 | How many of your natural mother's full more | N/A | ||
| PX510101_Number_Natural_Daughters | ||||
| PX510101060100 | How many natural daughters have you had who more | N/A | ||
| PX510101_Number_Natural_Maternal_Aunts | ||||
| PX510101100100 | How many full sisters did your natural more | N/A | ||
| PX510101_Number_Natural_Maternal_Uncles | ||||
| PX510101090100 | How many full brothers did your natural more | N/A | ||
| PX510101_Number_Natural_Paternal_Aunts | ||||
| PX510101080100 | How many full sisters did your natural more | N/A | ||
| PX510101_Number_Natural_Paternal_Uncles | ||||
| PX510101070100 | How many full brothers did your natural more | N/A | ||
| PX510101_Number_Natural_Sons | ||||
| PX510101050100 | How many natural sons have you had who lived more | N/A | ||
| PX510101_Number_Paternal_Aunts_Alcoholic | ||||
| PX510101080300 | How many of your natural father's full more | N/A | ||
| PX510101_Number_Paternal_Uncles_Alcoholic | ||||
| PX510101070300 | How many of your natural father's full more | N/A | ||
| PX510101_Number_Sisters_Alcoholic_Problem_Drinker | ||||
| PX510101040300 | How many of your full sisters are now, or more | N/A | ||
| PX510101_Number_Sons_Alcoholic_Problem_Drinker | ||||
| PX510101050300 | How many of your natural sons are now, or more | N/A | ||
| PX510101_Paternal_Aunt_Alcoholic_Problem_Drinker | ||||
| PX510101080200 | Was your natural father's full sister an more | N/A | ||
| PX510101_Paternal_Grandfather_Alcoholic | ||||
| PX510101110000 | Was your natural grandfather on your more | N/A | ||
| PX510101_Paternal_Grandmother_Alcoholic | ||||
| PX510101120000 | Was your natural grandmother on your more | N/A | ||
| PX510101_Paternal_Uncle_Alcoholic_Problem_Drinker | ||||
| PX510101070200 | Was your natural father's full brother an more | N/A | ||
| PX510101_Sister_Alcoholic_Problem_Drinker | ||||
| PX510101040200 | Was your full sister an alcoholic or problem more | N/A | ||
| PX510101_Son_Alcoholic_Problem_Drinker | ||||
| PX510101050200 | Was your natural son an alcoholic or problem more | N/A | ||
Measure Name
Family History of Substance Use Problems
Release Date
February 24, 2012
Definition
Instruments used separately to obtain family history of substance use problems including tobacco, alcohol, and other drugs.
Purpose
The purpose of this measure is to obtain a family history of substance use problems by asking the respondent whether or not any first- or second-degree biological relatives or spouses/partners have a history of problems with tobacco, alcohol, and other drugs.
Keywords
alcohol, Alcohol Use Disorder and Associated Disabilities Interview Schedule, AUDADIS, COGA, Collaborative Study on the Genetics of Alcoholism, Drugs, Family History, National Epidemiologic Survey on Alcohol and Related Conditions, NESARC, SAA, substance abuse, substance use, tobacco, Tobacco Family History Assessment Module, Assessment of Substance Use and Substance Use Disorders, gerontology, aging, geriatrics
Measure Protocols
| Protocol ID | Protocol Name |
|---|---|
| 510101 | Family History of Substance Use Problems - Alcohol |
| 510102 | Family History of Substance Use Problems - Drugs |
Publications
Weaver, S. R., et al. (2018) Establishing consensus on survey measures for electronic nicotine and non-nicotine delivery system use: Current challenges and considerations for researchers. Addict Behav. 2018 April; 79: 203-212. doi: 10.1016/j.addbeh.2017.11.016