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Protocol - Exogenous Female Hormone Use

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Description:

Female respondents self-report the use of estrogen and progesterone, including the duration and dose.

Specific Instructions:

None

Protocol:

1. Have you ever taken estrogen ("female hormones") for symptoms of menopause (the change of life) or for other reasons?

[ ] No (go to question 11)

[ ] Yes, and I am currently taking estrogens

[ ] Yes, but I am no longer taking estrogens

2. The most frequently used estrogen is oral Premarin®. Have you ever taken Premarin® by mouth (as pills)?

[ ] No (go to question 7)

[ ] Yes

3. At what age did you first take Premarin®?

[ ] Before age 45

[ ] 45-49

[ ] 50-54

[ ] 55-59

[ ] 60-64

[ ] 65-69

[ ] 70 or older

4. At what age did you last take Premarin®?

[ ] Currently taking

[ ] Before age 45

[ ] 45-49

[ ] 50-54

[ ] 55-59

[ ] 60-64

[ ] 65-69

[ ] 70 or older

5. How many years in total did you take Premarin® (exclude those periods when you temporarily stopped)?

YEARS __ (If less than 1 year, mark as 1)

6. Five commonly used doses of Premarin® can be distinguished by the color of the pill. Please indicate any you have ever used and the one you used for the longest period.

Ever Used

Longest Used

(Answer for each)

(Mark one)

No

Yes

[_]

Green (0.3 mg)

[_]

[_]

[_]

Brown/Red (0.625 mg)

[_]

[_]

[_]

White (0.9 mg)

[_]

[_]

[_]

Yellow/Orange (1.25 mg)

[_]

[_]

[_]

Purple (2.5 mg)

[_]

[_]

[_]

7. Have you ever used estrogen other than Premarin® pills? (Answer for each)

Estrogen by mouth

[ ] No

[ ] Yes

Estrogen by injection

[ ] No

[ ] Yes

Estrogen by patch or implant

[ ] No

[ ] Yes

Estrogen vaginal cream or suppository

[ ] No

[ ] Yes

If you answered no to all parts of question 7, go to question 11.

8. At what age did you first use estrogens other than Premarin® pills?

[ ] Before age 45

[ ] 45-49

[ ] 50-54

[ ] 55-59

[ ] 60-64

[ ] 65-69

[ ] 70 or older

9. At what age did you last use estrogens other than Premarin® pills?

[ ] Currently taking

[ ] Before age 45

[ ] 45-49

[ ] 50-54

[ ] 55-59

[ ] 60-64

[ ] 65-69

[ ] 70 or older

10. How many years in total did you take estrogens other than Premarin® pills (exclude any time when you temporarily stopped)?

[ ] Less than 1 year

[ ] 1-2

[ ] 3-5

[ ] 6-9

[ ] 10-14

[ ] 15-19

[ ] 20 years or more

11. Sometimes another type of female hormone, progesterone (or "progestin"), is given for symptoms of menopause, either alone or in combination with estrogen. The most frequently used progestin is Provera® (medroxyprogesterone acetate). Have you ever used progesterone or a progestin?

[ ] No (End Survey)

[ ] Provera® only

[ ] Another type only

[ ] Provera® and another type of progestin

[ ] Yes, but dont know type

12. At what age did you first take progesterone or a progestin?

[ ] Before age 40

[ ] 40-44

[ ] 45-49

[ ] 50-54

[ ] 55-59

[ ] 60-64

[ ] 65-69

[ ] 70 years or older

13. At what age did you last take progesterone or a progestin?

[ ] Currently taking

[ ] Before 45

[ ] 45-49

[ ] 50-54

[ ] 55-59

[ ] 60-64

[ ] 65-69

[ ] 70 years or older

14. How many years in total did you take progesterone or a progestin (excluding any time when you temporarily stopped)?

[ ] Less than 1 year

[ ] 1-2

[ ] 3-5

[ ] 6-9

[ ] 10-14

[ ] 15-19

[ ] 20 years or more

15. If you used Provera®, what was your usual dose?

[ ] Did not use Provera®

[ ] 2.5 mg per day

[ ] 5.0 mg per day

[ ] 10 mg per day

[ ] 20 mg per day

[ ] Another dose

[ ] Dont know

16. When using progestin or progesterone, for how many days each month would you usually take it?

[ ] __ DAYS

Premarin® is a registered trademark, Wyeth Pharmaceuticals, Inc.; Provera® is a registered trademark, Pfizer, Inc.

Protocol Name from Source:

Availability:

Publicly available

Personnel and Training Required

None

Equipment Needs

None

Requirements
Requirement CategoryRequired
Major equipment No
Specialized training No
Specialized requirements for biospecimen collection No
Average time of greater than 15 minutes in an unaffected individual No
Mode of Administration

Self-administered questionnaire

Life Stage:

Adult

Participants:

Females aged 21 years and older, current and former public school teachers or administrators who participate in the California State Teachers Retirement System (STRS)*

*While this protocol was used in a study of California women, the Cancer Working Group deems it appropriate to use with women aged 18 years old and above.

Selection Rationale

This protocol was selected because it obtains detailed information of the most frequently used female hormones: estrogen (Premarin®) and progesterone (Provera®).

Language

English

Standards
StandardNameIDSource
Common Data Elements (CDE) Person Female Hormone Use Text 2961276 CDE Browser
Logical Observation Identifiers Names and Codes (LOINC) Exogenous female hormone proto 62565-7 LOINC
Human Phenotype Ontology Abnormal circulating estrogen level HP:0025132 HPO
Derived Variables

None

Process and Review

Not applicable.

Source
State of California, The California Teachers Study, Baseline, Fall 1995, questions 41–56, pages 6 and 7 (source for questions 1–16).
General References

Protocol ID:

70401

Variables:
Export Variables
Variable Name Variable IDVariable DescriptiondbGaP Mapping
PX070401_Estrogen_Except_Premarin_Age_First
PX070401080000 At what age did you first use estrogens more
other than Premarin pills? show less
N/A
PX070401_Estrogen_Except_Premarin_Age_Last
PX070401090000 At what age did you last use estrogens other more
than Premarin pills? show less
N/A
PX070401_Estrogen_Except_Premarin_Years
PX070401100000 How many years in total did you take more
estrogens other than Premarin pills (exclude any time when you temporarily stopped)? show less
N/A
PX070401_Ever_Estrogen_By_Cream_Suppository
PX070401070400 Have you ever used estrogen other than more
Premarin pills? Estrogen vaginal cream or suppository? show less
N/A
PX070401_Ever_Estrogen_By_Injection
PX070401070200 Have you ever used estrogen other than more
Premarin pills? Estrogen by injection? show less
N/A
PX070401_Ever_Estrogen_By_Mouth
PX070401070100 Have you ever used estrogen other than more
Premarin pills? Estrogen by mouth? show less
N/A
PX070401_Ever_Estrogen_By_Patch_Implant
PX070401070300 Have you ever used estrogen other than more
Premarin pills? Estrogen by patch or implant? show less
N/A
PX070401_Ever_Premarin
PX070401020000 The most frequently used estrogen is oral more
Premarin. Have you ever taken Premarin by mouth (as pills)? show less
N/A
PX070401_Ever_Progesterone_Progestin
PX070401110000 Sometimes another type of female hormone, more
progesterone (or "progestin"), is given for symptoms of menopause, either alone or in combination with estrogen. The most frequently used progestin is Provera (medroxyprogestoerone acetate). Have you ever used progesterone or a progestin? show less
N/A
PX070401_Ever_Taken_Estrogen
PX070401010000 Have you ever taken estrogen ("female more
hormones") for symptoms of menopause (the change of life) or for other reasons? show less
Variable Mapping
PX070401_Premarin_Age_First
PX070401030000 At what age did you first take Premarin? N/A
PX070401_Premarin_Age_Last
PX070401040000 At what age did you last take Premarin? N/A
PX070401_Premarin_Dose_Brown_Red
PX070401060200 Five commonly used doses of Premarin can be more
distinguished by the color of the pill. Please indicate any you have ever used and the one you used for the longest period. Brown/Red (0.625 mg). show less
N/A
PX070401_Premarin_Dose_Green
PX070401060100 Five commonly used doses of Premarin can be more
distinguished by the color of the pill. Please indicate any you have ever used and the one you used for the longest period. Green (0.3 mg). show less
N/A
PX070401_Premarin_Dose_Longest_Used
PX070401060600 Longest Used N/A
PX070401_Premarin_Dose_Purple
PX070401060500 Five commonly used doses of Premarin can be more
distinguished by the color of the pill. Please indicate any you have ever used and the one you used for the longest period. Purple (2.5 mg). show less
N/A
PX070401_Premarin_Dose_White
PX070401060300 Five commonly used doses of Premarin can be more
distinguished by the color of the pill. Please indicate any you have ever used and the one you used for the longest period. White (0.9 mg). show less
N/A
PX070401_Premarin_Dose_Yellow_Orange
PX070401060400 Five commonly used doses of Premarin can be more
distinguished by the color of the pill. Please indicate any you have ever used and the one you used for the longest period. Yellow/Orange (1.25 mg). show less
N/A
PX070401_Premarin_Years
PX070401050000 How many years in total did you take more
Premarin (exclude those periods when you temporarily stopped)? show less
N/A
PX070401_Progesterone_Progestin_Age_First
PX070401120000 At what age did you first take progesterone more
or a progestin? show less
N/A
PX070401_Progesterone_Progestin_Age_Last
PX070401130000 At what age did you last take progesterone more
or a progestin? show less
Variable Mapping
PX070401_Progesterone_Progestin_Days
PX070401160000 When using progestin or progesterone, for more
how many days each month would you usually take it? show less
Variable Mapping
PX070401_Progesterone_Progestin_Years
PX070401140000 How many years in total did you take more
progesterone or a progestin (excluding any time when you temporarily stopped)? show less
Variable Mapping
PX070401_Provera_Dose
PX070401150000 If you used Provera, what was your usual dose? N/A
Cancer
Measure Name:

Exogenous Female Hormone Use

Release Date:

December 30, 2009

Definition

Measure to assess use of the hormones estrogen and progesterone

Purpose

Estrogen and progesterone use has been linked to cancer risk. Assessing use of these hormones will help quantify their association with either increased or decreased risk of cancer.

Keywords

cancer, estrogen, progesterone, Premarin®, Provera®, hormones, risk, The California Teachers Study (CTS)