Personnel and Training Required

This information should be abstracted by someone conversant in hematology.

Equipment Needs

None

Requirements

Requirement Category	Required
Major equipment	No
Specialized training	No
Specialized requirements for biospecimen collection	No
Average time of greater than 15 minutes in an unaffected individual	No

Mode of Administration

Medical record abstraction

Lifestage

Adult

Participants

This form is to be completed by designated personnel for all adverse transfusion reactions.

Selection Rationale

The Sickle Cell Disease Curative Therapies Working Group selected questions from the Sickle Cell Disease and Cardiovascular Risk—Red Cell Exchange (SCD-CARRE) as the best standardized methodology for collecting data on pre-transfusion antibody testing. 

Language

English

Standards

Standard	Name	ID	Source

Derived Variables

None

Process and Review

N/A

Protocol Name from Source

Sickle Cell Disease and Cardiovascular Risk—Red Cell Exchange Trial (SCD CARRE)

Source

National Heart, Lung, and Blood Institute. (2020). Sickle Cell Disease and CardiovAscular Risk—Red Cell Exchange (Version 1.0) [Laboratory evaluation].

General References

Chou, S T., Alsawas, M., Fasano, R. M., Field, J. J., Hendrickson, J. E., Howard, J., Kameka, M., Kwiatkowski, J. L., Pirenne, F., Shi, P. A., Stowell, S. R., Thein, S. L., Westhoff, C. M., Wong, T. E., & Akl, E. A. (2020). American Society of Hematology 2020 guidelines for sickle cell disease: Transfusion support. Blood Advances, 4(2), 327–355.

Protocol ID

850901

Variables

Export Variables

Variable Name	Variable ID	Variable Description	dbGaP Mapping
PX850901_Pretransfusion_Antibody_Reporting_Comments
	PX850901020400	Direct Antiglobulin Comments	N/A
PX850901_Pretransfusion_Antibody_Reporting_Date_Sample
	PX850901020200	Direct Antiglobulin Date of sample (If more different from above) dd-mon-yy show less	N/A
PX850901_Pretransfusion_Antibody_Reporting_Direct_Antiglobulin_Result
	PX850901020100	Direct Antiglobulin Result	N/A
PX850901_Pretransfusion_Antibody_Reporting_Direct_Antiglobulin_Result_Positive_C3
	PX850901020103	Direct Antiglobulin Result Positive C3	N/A
PX850901_Pretransfusion_Antibody_Reporting_Direct_Antiglobulin_Result_Positive_IgG
	PX850901020102	Direct Antiglobulin Result Positive IgG	N/A
PX850901_Pretransfusion_Antibody_Reporting_Direct_Antiglobulin_Result_Positive_Polyspecific
	PX850901020101	Direct Antiglobulin Result Positive Polyspecific	N/A
PX850901_Pretransfusion_Antibody_Reporting_Not_Done
	PX850901020300	Direct Antiglobulin Not Done	N/A
PX850901_Pretransfusion_Antibody_Reporting_RBC_Antibody_Screen_Comments
	PX850901010400	RBC Antibody Screen Comments	N/A
PX850901_Pretransfusion_Antibody_Reporting_RBC_Antibody_Screen_Date_Sample
	PX850901010200	RBC Antibody Screen Date of sample (If more different from above) dd-mon-yy show less	N/A
PX850901_Pretransfusion_Antibody_Reporting_RBC_Antibody_Screen_Not_Done
	PX850901010300	RBC Antibody Screen Not Done	N/A
PX850901_Pretransfusion_Antibody_Reporting_RBC_Antibody_Screen_Result
	PX850901010100	RBC Antibody Screen Result	N/A
PX850901_Pretransfusion_Antibody_Reporting_RBC_Antibody_Screen_Result_Positive
	PX850901010101	RBC Antibody Screen Result Positive	N/A
PX850901_Pretransfusion_Antibody_Reporting_RBC_Antibody_Screen_Result_Positive_Other
	PX850901010102	RBC Antibody Screen Result Positive Other	N/A

Curative Therapies

Measure Name

Pre-transfusion Antibody Reporting

Release Date

August 16, 2021

Definition

This measure is used to record the presence or absence of red cell antibodies.

Purpose

The transfusion recipient can mount an immune response to donor red blood cells, which can result in a hemolytic transfusion reaction, shock, kidney failure, circulatory system collapse, and death.

Keywords

sickle cell disease, SCD, transfusion, antibody, direct antiglobulin test, DAT

Measure Protocols

Protocol ID	Protocol Name
850901	Pre-transfusion Antibody Testing

Publications

There are no publications listed for this protocol.