Protocol - History of Prepubertal Development - Female
Female participants answer questions about when menstruation began and when they reached full height.
The PhenX Reproductive Health Working Group recommends adding the response categories "can’t remember" and "don’t know" to Question 1 for females.
1. How old were you when your menstrual periods began?
[ ] 9 or less
[ ] 10
[ ] 11
[ ] 12
[ ] 13
[ ] 14
[ ] 15
[ ] 16
[ ] 17 or more
[ ] never had periods
2. At about what age did you reach your full height?
[ ] Before age 13
[ ] 13 - 17 years of age
[ ] after age 17
[ ] don’t know
Personnel and Training Required
Pencil and paper for self-administered questions.
|Specialized requirements for biospecimen collection||No|
|Average time of greater than 15 minutes in an unaffected individual||No|
Mode of Administration
Females aged 21-64
The protocols are from well-established studies with questions that have been used for more than a decade.
|caDSR Common Data Elements (CDE)||Person Prepuberty Development History||3007456||CDE Browser|
|Logical Observation Identifiers Names and Codes (LOINC)||Hx prepubertal devel female proto||62657-2||LOINC|
|Human Phenotype Ontology||Puberty and gonadal disorders||HP:0008373||HPO|
Process and Review
The Expert Review Panel #5 (ERP 5) reviewed the measures in the Reproductive Health domain.
Guidance from ERP 5 includes:
- Revised descriptions of the measure
Back-compatible: no changes to Data Dictionary.
Previous version in Toolkit archive (link).
Protocol Name from Source
Black Women’s Health Study (BWHS)
Slone Epidemiology Center at Boston University. (1995). Black Women’s Health Study 1995. Boston, MA: Author. Question 7 (question 1). Slone Epidemiology Center at Boston University. (1999). Black Women’s Health Study 1999. Boston, MA: Author. Question 5 (question 2).
Jenner, M. R., Kelch, R. P., Kaplan, S. L., & Grümbach, M. M. (1972). Hormonal changes in puberty. IV. Plasma estradiol, LH, and FSH in prepubertal children, pubertal females, and in precocious puberty, premature thelarche, hypogonadism, and in a child with a feminizing ovarian tumor. Journal of Clinical Endocrinology and Metabolism, 34(3), 521-530.
Jost, A. (1970). Hormonal factors in the sex differentiation of the mammalian foetus. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 259(828), 119-130.
MacLaughlin, D. T., & Donahoe, P. K. (2004). Sex determination and differentiation. New England Journal of Medicine, 350(4), 367-378.
Maliqueo, M., Sir-Petermann, T., Perez, V., Echiburu, B., Guevara, L. A., Galvez, C., Crisosto, N., & Azziz, R. (2009). Adrenal Function during Childhood and Puberty in Daughters of Women with Polycystic Ovary Syndrome. Journal of Clinical Endocrinology and Metabolism, 94: 3282-3288.
Marshall, W., & Tanner, J. (1969). Variations in the pattern of pubertal changes in girls. Archives of Disease in Childhood, 44, 291-303.
Sizonenko, P. C., Burr, I. M., Kaplan, S. L., & Grumbach, M. M. (1970). Hormonal changes in puberty. II. Correlation of serum luteinizing hormone and follicle stimulating hormone with stages of puberty and bone age in normal girls. Pediatric Research, 4(1), 36-45.
|Variable Name||Variable ID||Variable Description||dbGaP Mapping|
|PX100601010000||How old were you when your menstrual periods more||Variable Mapping|
|PX100601020000||At about what age did you reach your full height?||N/A|
History of Prepubertal Development
February 26, 2010
Questions to assess how old participants were when they reached puberty.
The purpose of these questions is to determine when participants reached puberty. It is important to measure because it is linked to sexual development and maturity.
Reproductive health, puberty, Black Women’s Health Study, BWHS, Study for Future Families, SFF, National Longitudinal Survey of Youth, NLSY