PhenX Toolkit: Domains

Select	Protocol	ID
	Assessment of Pubertal Development - Child and Adolescent Female Avon Longitudinal Study of Parents and Children (ALSPAC), Growing and Changing (8), Mother/Daughter Questionnaire - 97 - 157 Months	#100103
	Assessment of Pubertal Development - Child and Adolescent Male Avon Longitudinal Study of Parents and Children (ALSPAC), Growing and Changing, Parent/Son Questionnaire- 97 - 157 Months	#100104
	Assessment of Pubertal Development - Teenage Female Avon Longitudinal Study of Parents and Children (ALSPAC), Growing and Changing (8), Female Teenage Questionnaire - 175 - 204 Months	#100101
	Assessment of Pubertal Development - Teenage Male Avon Longitudinal Study of Parents and Children (ALSPAC), Growing and Changing (8), Male Teenage Questionnaire	#100102
	Causes and Treatments of Known Infertility - Female National Survey of Family Growth (NFSG), 2013-2015	#100204
	Causes and Treatments of Known Infertility - Male National Survey of Family Growth (NFSG), Male, 2013-2015	#100203
	Current Contraception Use - Female National Survey of Family Growth (NFSG), 2013-2015	#100303
	Current Contraception Use - Male National Survey of Family Growth (NFSG), Male, 2013-2015	#100304
	Difficulty Getting Pregnant - Current Duration Slama, R., et al, Feasibility of the Current-Duration Approach to Studying Human Fecundity, EPIDEMIOLOGY, 2006	#100402
	Difficulty Getting Pregnant - Prospective Assessment Pregnancy Study Online (PRESTO), Female Screener and Baseline Questionnaire	#100403
	Difficulty Getting Pregnant - Retrospective Assessment Slama, R., et al, Epidemiologic tools to study the influence of environmental factors on fecundity and pregnancy-related outcomes, EPIDEMIOL REVs, 2014	#100404
	History of Prepubertal Development - Female Black Women?s Health Study (BWHS), 1995	#100601
	History of Prepubertal Development - Male Study for Future Families (SFF) & National Longitudinal Survey of Youth (NLSY)	#100602
	Hormonal Therapy Nurses? Health Study II (NHS II), 2015	#100702
	Human Papillomavirus Vaccine Use Behavioral Risk Factor Surveillance System (BRFSS), 2014	#100802
	Male Fertility Status WHO Laboratory Manual for the Examination and Processing of Human Semen, Fifth Edition, 2010	#101601
	Male Reproductive Tract Birth Defects Study For Future Families	#100901
	Male Sexual Function Study for Future Families & International Index of Erectile Function (IIEF)	#101001
	Menstrual History Nurses? Health Study (NHS), Black Women?s Health Study (BWHS), Study of Women Across the Nation (SWAN)	#101101
	Prostate Symptoms International Prostate Symptom Score (I-PSS)	#101202
	Removal of Female Reproductive Organs National Survey of Family Growth (NSFG), 2011-2013	#100502
	Reproductive History - Female Women?s Interview Study of Health & Pregnancy Risk Assessment Monitoring System (PRAMS), 2009	#101301
	Reproductive History - Male The Longitudinal Investigation of Fertility & the Environment (LIFE) Study, 2005	#101302
	Sexual Risk Behavior - Female National Health and Nutrition Examination Survey (NHANES), Sexual Behavior Module, 2011-2012	#101702
	Sexual Risk Behavior - Male National Health and Nutrition Examination Survey (NHANES), Sexual Behavior Module, 2011-2012	#101701
	Testes Volume Melmed, S., et al. Williams textbook of endocrinology, 2008	#101501

Release Date:

February 26, 2010; reviewed April 11, 2017

Scope of Domain:

Scope Elements	Final Protocols To Toolkit (26)
Maturation	Assessment of Pubertal Development
Infertility, known infertility, cause of known infertility, any use of infertility treatment	Causes and Treatments of Known Infertility
Contraceptive use (including hormonal contraception), voluntary sterilization, condom or other male-oriented contraceptive use	Contraceptive Methods
Infertile periods (periods of unprotected sex without pregnancy)	Difficulty in Conceiving
Surgical procedures (e.g., oophorectomy, hysterectomy)	Female Reproductive Organ Surgical Procedures
Hormone replacement therapy	Hormonal Therapy
HPV vaccinations, e.g., Gardasil	Human Papillomavirus Use
Age at menarche; age at puberty; maturation, first-time masturbation/ejaculation, prepubertal questions	History of Prepubertal Development
Hypogonadal, hypospadias, cryptorchidism, prepuberty	Male Reproductive Tract Birth Defects
Age at menopause; extended periods of amenorrhea	Menstrual History
Prostate diseases and symptoms	Prostate Health
Number of pregnancies and spacing; outcome of each pregnancy; maternal complications (pregnancy-related death or morbidity); infant health parameters (preterm, low birth weight, congenital anomalies, gestational age); alcohol use; number of pregnancies fathered	Reproductive History
Sexual difficulties	Sexual Function, Male
Age at first intercourse; number of sexual partners	Sexual History
Maturation through clinical exam	Testes Development
Current sexual activity	Current Sexual Activity (supplemental)
Rape and other sexual abuse	Forced Sexual Activity (supplemental)

Working Group Roster:

WG Members:

Carol Hogue, PhD, Chair Emory University Atlanta, GA	Stephanie Seminara, MD Massachusetts General Hospital Boston, MA
Andrea Dunaif, MD Northwestern University Evanston, IL	Rebecca Sokol, MD University of Southern California Los Angeles, CA
Russ Hauser, MD, ScD Harvard University Belmont, MA	Jun (Jim) Zhang, MD, PhD Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Rockville, MD
Pauline Mendola, PhD Centers for Disease Control and Prevention Prevention/National Center for Health Statistics Hyattsville, MD

SC Liaison, WG Manager and WG Supervisor:

Michelle A. Williams, ScD, SC Liaison Harvard School of Public Health Boston, MA	Sonja Hoover, MPP, WG Manager RTI International Waltham, MA
Richard Kwok, PhD, WG Supervisor RTI International Research Triangle Park, NC

Expert Review Panel 5 - Reproductive Health domain:

ERP Members:

John Amory, MD
University of Washington
Seattle, WA

Courtney Lynch, PhD
The Ohio State University
Columbus, OH

SC Liaison, ERP Manager and ERP Supervisor:

Elaine M. Faustman, PhD, SC Liaison University of Washington Seattle, WA	Lisa Cox, MS, ERP Manager RTI International Atlanta, GA
Michael Phillips, MS, ERP Supervisor RTI International Research Triangle Park, NC

Reproductive Health Supplemental Information includes:

Additional Information for Reproductive Health Measures:

There is no additional information for this domain.

Protocol Name	ID	Status	DCW	DD	DD Mapping
Causes and Treatments of Known Infertility - Female	100202	updated	DCW	DD	DD Mapping
Causes and Treatments of Known Infertility - Male	100201	updated	DCW	DD	DD Mapping
Contraceptive Methods - Female	100301	replaced	DCW	DD	N/A
Contraceptive Methods - Male	100302	updated	DCW	DD	DD Mapping
Difficulty in Conceiving	100401	replaced	DCW	DD	N/A
Female Reproductive Organ Surgical Procedures	100501	replaced	DCW	DD	DD Mapping
History of Prepubertal Development - Female	100601	minor edits	DCW	N/A	N/A
History of Prepubertal Development - Male	100602	minor edits	DCW	N/A	N/A
Hormonal Therapy	100701	updated	DCW	DD	DD Mapping
Human Papillomavirus Vaccine Use	100801	updated	DCW	DD	DD Mapping
Male Reproductive Tract Birth Defects	100901	minor edits	DCW	DD	DD Mapping
Male Sexual Function	101001	minor edits	DCW	N/A	N/A
Menstrual History	101101	minor edits	DCW	N/A	N/A
Prostate Health	101201	replaced	DCW	DD	DD Mapping
Sexual History	101401	retired	DCW	N/A	N/A
Testes Volume	101501	minor edits	DCW	N/A	N/A
SI-Current_Sexual_Activity	000000	retired	N/A	N/A	N/A
SI–Sexual Violence	000000	replaced	N/A	N/A	N/A

Select	Measure Name	Protocols
	Assessment of Pubertal Development	Assessment of Pubertal Development - Teenage Female Assessment of Pubertal Development - Teenage Male Assessment of Pubertal Development - Child and Adolescent Female Assessment of Pubertal Development - Child and Adolescent Male
	Causes and Treatments of Known Infertility	Causes and Treatments of Known Infertility - Male Causes and Treatments of Known Infertility - Female Causes and Treatments of Known Infertility - Male Causes and Treatments of Known Infertility - Female
	Current Contraception Use	Contraceptive Methods - Female Contraceptive Methods - Male Current Contraception Use - Female Current Contraception Use - Male
	Difficulty Getting Pregnant	Difficulty in Conceiving Difficulty Getting Pregnant - Current Duration Difficulty Getting Pregnant - Prospective Assessment Difficulty Getting Pregnant - Retrospective Assessment
	Removal of Female Reproductive Organs	Female Reproductive Organ Surgical Procedures Removal of Female Reproductive Organs
	History of Prepubertal Development	History of Prepubertal Development - Female History of Prepubertal Development - Male
	Hormonal Therapy	Hormonal Therapy Hormonal Therapy
	Human Papillomavirus Vaccine Use	Human Papillomavirus Vaccine Use Human Papillomavirus Vaccine Use
	Male Reproductive Tract Birth Defects	Male Reproductive Tract Birth Defects
	Male Sexual Function	Male Sexual Function
	Menstrual History	Menstrual History
	Prostate Symptoms	Prostate Health Prostate Symptoms
	Reproductive History	Reproductive History - Female Reproductive History - Male
	Sexual History	Sexual History
	Testes Volume	Testes Volume
	Male Fertility Status	Male Fertility Status
	Sexual Risk Behavior	Sexual Risk Behavior - Male Sexual Risk Behavior - Female

Research Domain - Reproductive Health

Research Domains:

Assessment of Pubertal Development - Child and Adolescent Female Avon Longitudinal Study of Parents and Children (ALSPAC), Growing and Changing (8), Mother/Daughter Questionnaire - 97 - 157 Months

#100103

Assessment of Pubertal Development - Child and Adolescent Male Avon Longitudinal Study of Parents and Children (ALSPAC), Growing and Changing, Parent/Son Questionnaire- 97 - 157 Months

#100104

Assessment of Pubertal Development - Teenage Female Avon Longitudinal Study of Parents and Children (ALSPAC), Growing and Changing (8), Female Teenage Questionnaire - 175 - 204 Months

#100101

Assessment of Pubertal Development - Teenage Male Avon Longitudinal Study of Parents and Children (ALSPAC), Growing and Changing (8), Male Teenage Questionnaire

#100102

Causes and Treatments of Known Infertility - Female National Survey of Family Growth (NFSG), 2013-2015

#100204

Causes and Treatments of Known Infertility - Male National Survey of Family Growth (NFSG), Male, 2013-2015

#100203

Current Contraception Use - Female National Survey of Family Growth (NFSG), 2013-2015

#100303

Current Contraception Use - Male National Survey of Family Growth (NFSG), Male, 2013-2015

#100304

Difficulty Getting Pregnant - Current Duration Slama, R., et al, Feasibility of the Current-Duration Approach to Studying Human Fecundity, EPIDEMIOLOGY, 2006

#100402

Difficulty Getting Pregnant - Prospective Assessment Pregnancy Study Online (PRESTO), Female Screener and Baseline Questionnaire

#100403

Difficulty Getting Pregnant - Retrospective Assessment Slama, R., et al, Epidemiologic tools to study the influence of environmental factors on fecundity and pregnancy-related outcomes, EPIDEMIOL REVs, 2014

#100404

History of Prepubertal Development - Female Black Women?s Health Study (BWHS), 1995

#100601

History of Prepubertal Development - Male Study for Future Families (SFF) & National Longitudinal Survey of Youth (NLSY)

#100602

Hormonal Therapy Nurses? Health Study II (NHS II), 2015

#100702

Human Papillomavirus Vaccine Use Behavioral Risk Factor Surveillance System (BRFSS), 2014

#100802

Male Fertility Status WHO Laboratory Manual for the Examination and Processing of Human Semen, Fifth Edition, 2010

#101601

Male Reproductive Tract Birth Defects Study For Future Families

#100901

Male Sexual Function Study for Future Families & International Index of Erectile Function (IIEF)

#101001

Menstrual History Nurses? Health Study (NHS), Black Women?s Health Study (BWHS), Study of Women Across the Nation (SWAN)

#101101

Prostate Symptoms International Prostate Symptom Score (I-PSS)

#101202

Removal of Female Reproductive Organs National Survey of Family Growth (NSFG), 2011-2013

#100502

Reproductive History - Female Women?s Interview Study of Health & Pregnancy Risk Assessment Monitoring System (PRAMS), 2009

#101301

Reproductive History - Male The Longitudinal Investigation of Fertility & the Environment (LIFE) Study, 2005

#101302

Sexual Risk Behavior - Female National Health and Nutrition Examination Survey (NHANES), Sexual Behavior Module, 2011-2012

#101702

Sexual Risk Behavior - Male National Health and Nutrition Examination Survey (NHANES), Sexual Behavior Module, 2011-2012

#101701

Testes Volume Melmed, S., et al. Williams textbook of endocrinology, 2008

#101501

Release Date:

Scope of Domain:

Working Group Roster:

Expert Review Panel 5 - Reproductive Health domain:

Reproductive Health Supplemental Information includes:

Additional Information for Reproductive Health Measures:

Assessment of Pubertal Development - Child and Adolescent Female
Avon Longitudinal Study of Parents and Children (ALSPAC), Growing and Changing (8), Mother/Daughter Questionnaire - 97 - 157 Months

Assessment of Pubertal Development - Child and Adolescent Male
Avon Longitudinal Study of Parents and Children (ALSPAC), Growing and Changing, Parent/Son Questionnaire- 97 - 157 Months

Assessment of Pubertal Development - Teenage Female
Avon Longitudinal Study of Parents and Children (ALSPAC), Growing and Changing (8), Female Teenage Questionnaire - 175 - 204 Months

Assessment of Pubertal Development - Teenage Male
Avon Longitudinal Study of Parents and Children (ALSPAC), Growing and Changing (8), Male Teenage Questionnaire

Causes and Treatments of Known Infertility - Female
National Survey of Family Growth (NFSG), 2013-2015

Causes and Treatments of Known Infertility - Male
National Survey of Family Growth (NFSG), Male, 2013-2015

Current Contraception Use - Female
National Survey of Family Growth (NFSG), 2013-2015

Current Contraception Use - Male
National Survey of Family Growth (NFSG), Male, 2013-2015

Difficulty Getting Pregnant - Current Duration
Slama, R., et al, Feasibility of the Current-Duration Approach to Studying Human Fecundity, EPIDEMIOLOGY, 2006

Difficulty Getting Pregnant - Prospective Assessment
Pregnancy Study Online (PRESTO), Female Screener and Baseline Questionnaire

Difficulty Getting Pregnant - Retrospective Assessment
Slama, R., et al, Epidemiologic tools to study the influence of environmental factors on fecundity and pregnancy-related outcomes, EPIDEMIOL REVs, 2014

History of Prepubertal Development - Female
Black Women?s Health Study (BWHS), 1995

History of Prepubertal Development - Male
Study for Future Families (SFF) & National Longitudinal Survey of Youth (NLSY)

Hormonal Therapy
Nurses? Health Study II (NHS II), 2015

Human Papillomavirus Vaccine Use
Behavioral Risk Factor Surveillance System (BRFSS), 2014

Male Fertility Status
WHO Laboratory Manual for the Examination and Processing of Human Semen, Fifth Edition, 2010

Male Reproductive Tract Birth Defects
Study For Future Families

Male Sexual Function
Study for Future Families & International Index of Erectile Function (IIEF)

Menstrual History
Nurses? Health Study (NHS), Black Women?s Health Study (BWHS), Study of Women Across the Nation (SWAN)

Prostate Symptoms
International Prostate Symptom Score (I-PSS)

Removal of Female Reproductive Organs
National Survey of Family Growth (NSFG), 2011-2013

Reproductive History - Female
Women?s Interview Study of Health & Pregnancy Risk Assessment Monitoring System (PRAMS), 2009

Reproductive History - Male
The Longitudinal Investigation of Fertility & the Environment (LIFE) Study, 2005

Sexual Risk Behavior - Female
National Health and Nutrition Examination Survey (NHANES), Sexual Behavior Module, 2011-2012

Sexual Risk Behavior - Male
National Health and Nutrition Examination Survey (NHANES), Sexual Behavior Module, 2011-2012

Testes Volume
Melmed, S., et al. Williams textbook of endocrinology, 2008