PhenX Toolkit: Domains

Select	Protocol	ID
	Assessment of Pubertal Development - Female Avon Longitudinal Study of Parents and Children (ALSPAC). Growing and Changing (8), Female Teenage Questionnaire	#100101
	Assessment of Pubertal Development - Male Avon Longitudinal Study of Parents and Children (ALSPAC). Growing and Changing (8), Male Teenager Questionnaire	#100102
	Causes and Treatments of Known Infertility - Female National Survey of Family Growth (NSFG)	#100204
	Causes and Treatments of Known Infertility - Male National Survey of Family Growth (NSFG)	#100203
	Current Contraception Use - Female National Survey of Family Growth	#100303
	Current Contraception Use - Male National Survey of Family Growth (NSFG)	#100304
	Difficulty Getting Pregnant - Current Duration	#100402
	Difficulty Getting Pregnant - Prospective Assessment Pregnancy Study Online (PRESTO) Female Screener and Baseline Questionnaire	#100403
	Difficulty Getting Pregnant - Retrospective Assessment	#100404
	History of Prepubertal Development - Female Black Women’s Health Study (BWHS)	#100601
	History of Prepubertal Development - Male Study for Future Families (SFF) and National Longitudinal Survey of Youth (NLSY)	#100602
	Hormonal Therapy Nurses’ Health Study II (NHS II)	#100702
	Human Papillomavirus Vaccine Use Behavioral Risk Factor Surveillance System (BRFSS)	#100802
	Male Fertility Status WHO Laboratory Manual for the Examination and Processing of Human Semen, Fifth Edition	#101601
	Male Reproductive Tract Birth Defects Study For Future Families	#100901
	Male Sexual Function Study for Future Families and International Index of Erectile Function (IIEF)	#101001
	Menstrual History Nurses’ Health Study (NHS), Black Women’s Health Study (BWHS), Study of Women Across the Nation (SWAN)	#101101
	Prostate Symptoms International Prostate Symptom Score (I-PSS)	#101202
	Removal of Female Reproductive Organs National Survey of Family Growth (NSFG)	#100502
	Reproductive History - Female Women’s Interview Study of Health and Pregnancy Risk Assessment Monitoring System (PRAMS)	#101301
	Reproductive History - Male The Longitudinal Investigation of Fertility and the Environment (LIFE) Study	#101302
	Sexual Risk Behavior - Female National Health and Nutrition Examination Survey (NHANES) Sexual Behavior Module	#101702
	Sexual Risk Behavior - Male National Health and Nutrition Examination Survey (NHANES) Sexual Behavior Module	#101701
	Testes Volume Assessment of Sexual Maturity Stages in Girls and Boys and Williams Textbook of Endocrinology	#101501

Release Date:

February 26, 2010; reviewed April 11, 2017

Scope of Domain:

Scope Elements	Final Protocols To Toolkit (17)
Maturation	Assessment of Pubertal Development
Infertility, known infertility, cause of known infertility, any use of infertility treatment	Causes and Treatments of Known Infertility
Contraceptive use (including hormonal contraception), voluntary sterilization, condom or other male-oriented contraceptive use	Contraceptive Methods
Infertile periods (periods of unprotected sex without pregnancy)	Difficulty in Conceiving
Surgical procedures (e.g., oophorectomy, hysterectomy)	Female Reproductive Organ Surgical Procedures
Hormone replacement therapy	Hormonal Therapy
HPV vaccinations, e.g., Gardasil	Human Papillomavirus Use
Age at menarche; age at puberty; maturation, first-time masturbation/ejaculation, prepubertal questions	History of Prepubertal Development
Hypogonadal, hypospadias, cryptorchidism, prepuberty	Male Reproductive Tract Birth Defects
Age at menopause; extended periods of amenorrhea	Menstrual History
Prostate diseases and symptoms	Prostate Health
Number of pregnancies and spacing; outcome of each pregnancy; maternal complications (pregnancy-related death or morbidity); infant health parameters (preterm, low birth weight, congenital anomalies, gestational age); alcohol use; number of pregnancies fathered	Reproductive History
Sexual difficulties	Sexual Function, Male
Age at first intercourse; number of sexual partners	Sexual History
Maturation through clinical exam	Testes Development
Current sexual activity	Current Sexual Activity (supplemental)
Rape and other sexual abuse	Forced Sexual Activity (supplemental)

Working Group Roster:

WG Members:

Carol Hogue, PhD, Chair Emory University Atlanta, GA	Stephanie Seminara, MD Massachusetts General Hospital Boston, MA
Andrea Dunaif, MD Northwestern University Evanston, IL	Rebecca Sokol, MD University of Southern California Los Angeles, CA
Russ Hauser, MD, ScD Harvard University Belmont, MA	Jun (Jim) Zhang, MD, PhD Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Rockville, MD
Pauline Mendola, PhD Centers for Disease Control and Prevention Prevention/National Center for Health Statistics Hyattsville, MD

SC Liaison, WG Manager and WG Supervisor:

Michelle A. Williams, ScD, SC Liaison Harvard University School of Public Health Belmont, MA	Sonja Hoover, MPP, WG Manager RTI International Waltham, MA
Richard Kwok, PhD, WG Supervisor RTI International Research Triangle Park, NC

Expert Review Panel 5 - Reproductive Health domain:

ERP Members:

John Amory, MD
University of Washington
Seattle, WA

Courtney Lynch, PhD
The Ohio State University
Columbus, OH

SC Liaison, ERP Manager and ERP Supervisor:

Elaine M. Faustman, PhD, SC Liaison University of Washington Seattle, WA	Lisa Cox, MS, ERP Manager RTI International Atlanta, GA
Michael Phillips, MS, ERP Supervisor RTI International Research Triangle Park, NC

Reproductive Health Supplemental Information includes:

Additional Information for Reproductive Health Measures:

There is no additional information for this domain.

Protocol Name	Status	DCW	DD	DD Mapping
Causes and Treatments of Known Infertility - Female	updated	DCW	DD	DD Mapping
Causes and Treatments of Known Infertility - Male	updated	DCW	DD	DD Mapping
Contraceptive Methods - Female	replaced	DCW	DD	N/A
Contraceptive Methods - Male	updated	DCW	DD	DD Mapping
Difficulty in Conceiving	replaced	DCW	DD	N/A
Female Reproductive Organ Surgical Procedures	replaced	DCW	DD	DD Mapping
History of Prepubertal Development - Female	minor edits	DCW	N/A	N/A
History of Prepubertal Development - Male	minor edits	DCW	N/A	N/A
Hormonal Therapy	updated	DCW	DD	DD Mapping
Human Papillomavirus Vaccine Use	updated	DCW	DD	DD Mapping
Male Reproductive Tract Birth Defects	minor edits	DCW	DD	DD Mapping
Male Sexual Function	minor edits	DCW	N/A	N/A
Menstrual History	minor edits	DCW	N/A	N/A
Prostate Health	replaced	DCW	DD	DD Mapping
Sexual History	retired	DCW	N/A	N/A
Testes Volume	minor edits	DCW	N/A	N/A
SI-Current_Sexual_Activity	retired	N/A	N/A	N/A
SI–Sexual Violence	replaced	N/A	N/A	N/A

Research Domain - Reproductive Health

Research Domains:

Assessment of Pubertal Development - Female Avon Longitudinal Study of Parents and Children (ALSPAC). Growing and Changing (8), Female Teenage Questionnaire

#100101

Assessment of Pubertal Development - Male Avon Longitudinal Study of Parents and Children (ALSPAC). Growing and Changing (8), Male Teenager Questionnaire

#100102

Causes and Treatments of Known Infertility - Female National Survey of Family Growth (NSFG)

#100204

Causes and Treatments of Known Infertility - Male National Survey of Family Growth (NSFG)

#100203

Current Contraception Use - Female National Survey of Family Growth

#100303

Current Contraception Use - Male National Survey of Family Growth (NSFG)

#100304

Difficulty Getting Pregnant - Current Duration

#100402

Difficulty Getting Pregnant - Prospective Assessment Pregnancy Study Online (PRESTO) Female Screener and Baseline Questionnaire

#100403

Difficulty Getting Pregnant - Retrospective Assessment

#100404

History of Prepubertal Development - Female Black Women’s Health Study (BWHS)

#100601

History of Prepubertal Development - Male Study for Future Families (SFF) and National Longitudinal Survey of Youth (NLSY)

#100602

Hormonal Therapy Nurses’ Health Study II (NHS II)

#100702

Human Papillomavirus Vaccine Use Behavioral Risk Factor Surveillance System (BRFSS)

#100802

Male Fertility Status WHO Laboratory Manual for the Examination and Processing of Human Semen, Fifth Edition

#101601

Male Reproductive Tract Birth Defects Study For Future Families

#100901

Male Sexual Function Study for Future Families and International Index of Erectile Function (IIEF)

#101001

Menstrual History Nurses’ Health Study (NHS), Black Women’s Health Study (BWHS), Study of Women Across the Nation (SWAN)

#101101

Prostate Symptoms International Prostate Symptom Score (I-PSS)

#101202

Removal of Female Reproductive Organs National Survey of Family Growth (NSFG)

#100502

Reproductive History - Female Women’s Interview Study of Health and Pregnancy Risk Assessment Monitoring System (PRAMS)

#101301

Reproductive History - Male The Longitudinal Investigation of Fertility and the Environment (LIFE) Study

#101302

Sexual Risk Behavior - Female National Health and Nutrition Examination Survey (NHANES) Sexual Behavior Module

#101702

Sexual Risk Behavior - Male National Health and Nutrition Examination Survey (NHANES) Sexual Behavior Module

#101701

Testes Volume Assessment of Sexual Maturity Stages in Girls and Boys and Williams Textbook of Endocrinology

#101501

Release Date:

Scope of Domain:

Working Group Roster:

Expert Review Panel 5 - Reproductive Health domain:

Reproductive Health Supplemental Information includes:

Additional Information for Reproductive Health Measures:

Assessment of Pubertal Development - Female

Avon Longitudinal Study of Parents and Children (ALSPAC). Growing and Changing (8), Female Teenage Questionnaire

Assessment of Pubertal Development - Male

Avon Longitudinal Study of Parents and Children (ALSPAC). Growing and Changing (8), Male Teenager Questionnaire

Causes and Treatments of Known Infertility - Female

National Survey of Family Growth (NSFG)

Causes and Treatments of Known Infertility - Male

National Survey of Family Growth (NSFG)

Current Contraception Use - Female

National Survey of Family Growth

Current Contraception Use - Male

National Survey of Family Growth (NSFG)

Difficulty Getting Pregnant - Prospective Assessment

Pregnancy Study Online (PRESTO) Female Screener and Baseline Questionnaire

History of Prepubertal Development - Female

Black Women’s Health Study (BWHS)

History of Prepubertal Development - Male

Study for Future Families (SFF) and National Longitudinal Survey of Youth (NLSY)

Hormonal Therapy

Nurses’ Health Study II (NHS II)

Human Papillomavirus Vaccine Use

Behavioral Risk Factor Surveillance System (BRFSS)

Male Fertility Status

WHO Laboratory Manual for the Examination and Processing of Human Semen, Fifth Edition

Male Reproductive Tract Birth Defects

Study For Future Families

Male Sexual Function

Study for Future Families and International Index of Erectile Function (IIEF)

Menstrual History

Nurses’ Health Study (NHS), Black Women’s Health Study (BWHS), Study of Women Across the Nation (SWAN)

Prostate Symptoms

International Prostate Symptom Score (I-PSS)

Removal of Female Reproductive Organs

National Survey of Family Growth (NSFG)

Reproductive History - Female

Women’s Interview Study of Health and Pregnancy Risk Assessment Monitoring System (PRAMS)

Reproductive History - Male

The Longitudinal Investigation of Fertility and the Environment (LIFE) Study

Sexual Risk Behavior - Female

National Health and Nutrition Examination Survey (NHANES) Sexual Behavior Module

Sexual Risk Behavior - Male

National Health and Nutrition Examination Survey (NHANES) Sexual Behavior Module

Testes Volume

Assessment of Sexual Maturity Stages in Girls and Boys and Williams Textbook of Endocrinology