Protocol - Executive Function - Direct Assessment - Adult
The Trail Making Test (TMT) is an interviewer-administered, two-part test that requires the respondent to organize numerical and alphabetical sequences that are randomly distributed on a piece of paper. The protocol for TMT includes instructions for correcting mistakes and instructions for scoring based on speed and accuracy.
Whereas the Trail Making Test (TMT) has two parts (Parts A and B), the PhenX Neurology Working Group recommends that Part B be used to measure executive function in adults.
The TMT is a proprietary, fee-based instrument that is available from Reitan Neuropsychology Lab, Inc.
Trail Making Test, Part A
The examiner first shows the respondent a sample test that has numbers 1-8 distributed in random order. The examiner demonstrates the task and lets the respondent practice connecting the numbers in increasing order. The examiner then hands the respondent the actual test which has the numbers 1-25 distributed in random order and asks the respondent to connect them in increasing order as fast as possible without raising the pen from the paper. Respondents are scored based on speed and accuracy.
Trail Making Test, Part B
The examiner first shows the respondent a sample test that has numbers 1-4 and letters A-D distributed in random order. The examiner demonstrates the task and lets the respondent practice connecting the numbers to letters (one to A, A to two, etc.) in increasing order. The examiner then hands the respondent the actual test which has the numbers 1-13 and letters A-L distributed in random order and asks the respondent to connect them in increasing order as fast as possible without raising the pen from the paper. Respondents are scored based on speed and accuracy.
Protocol Name from Source:
The Trail Making Test
Personnel and Training Required
Personnel should be trained by a licensed neuropsychologist or other trained medical professional experienced with the Trail Making Test. Additionally, investigators are encouraged to have quality control procedures (such as videotaping sessions, etc.) in place to maintain consistency across examiners.
The interviewer will need a copy of the test that includes the cue cards with the sequence of numbers and letters and the scoring instructions.
|Specialized requirements for biospecimen collection||No|
|Average time of greater than 15 minutes in an unaffected individual||No|
Mode of Administration
Adolescent, Adult, Senior
Participant ages 15 years and older.
The Trail Making Test was selected because it is a standard, widely used, validated protocol.
|Common Data Elements (CDE)||Adult Trail Making Test Assessment Text||6454609||CDE Browser|
Process and Review
The Expert Review Panel 4 (ERP 4) reviewed the measures in the Neurology, Psychiatric, and Psychosocial domains.
Guidance from ERP 4 included the following:
- Added new measure
- No changes to existing protocol
Reitan Neuropsychology Lab. The Adult Trail Making Test (TMT).
The TMT is a proprietary instrument and can be obtained through:
Reitan Neuropsychology Lab
P.O. Box 66080
Tucson, AZ 85728-6080
Telephone: (520) 577-2970
Fax: (520) 577-2940
|Variable Name||Variable ID||Variable Description||dbGaP Mapping|
|PX131602000000||Protocol 131602 - proprietary. Check DCW for more||N/A|
Executive Function - Direct Assessment
November 28, 2017
An interviewer-administered test to measure a respondent’s system of high-level cognitive functions such as abstract thinking, rule acquisition, cognitive flexibility, and goal-oriented behavior.
This measure tests a respondent’s total range of function with respect to executive function. It is therefore more specific and sensitive than a measure of global mental status and can be used to assess major problems in executive function as well as minor variations that may be a consequence of normal development and aging.
neurology, sickle cell disease, SCD, cognition, dementia, Alzheimer’s disease, aging, proprietary, attention deficient hyperactivity disorder, ADHD, gerontology, aging, geriatrics