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Protocol - Diabetic Peripheral Neuropathy

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Description:

The Michigan Neuropathy Screening Instrument (MNSI) consists of 15 yes-or-no questions that assess feelings in the legs and feet (distal symmetric polyneuropathy). The MNSI also includes a clinical examination that is not included here.

Protocol:

Please take a few minutes to answer the questions below about the feeling in your legs and feet. Check yes or no based on how you usually feel.

1. Are your legs and/or feet numb?

[ ] Yes

[ ] No

2. Do you ever have any burning pain in your legs and/or feet?

[ ] Yes

[ ] No

3. Are your feet too sensitive to touch?

[ ] Yes

[ ] No

4. Do you get muscle cramps in your legs and/or feet?

[ ] Yes

[ ] No

5. Do you ever have any prickling feelings in your legs or feet?

[ ] Yes

[ ] No

6. Does it hurt when the bed covers touch your skin?

[ ] Yes

[ ] No

7. When you get into the tub or shower, are you able to tell the hot water from the cold water?

[ ] Yes

[ ] No

8. Have you ever had an open sore on your foot?

[ ] Yes

[ ] No

9. Has your doctor ever told you that you have diabetic neuropathy?

[ ] Yes

[ ] No

10. Do you feel weak all over most of the time?

[ ] Yes

[ ] No

11. Are your symptoms worse at night?

[ ] Yes

[ ] No

12. Do your legs hurt when you walk?

[ ] Yes

[ ] No

13. Are you able to sense your feet when you walk?

[ ] Yes

[ ] No

14. Is the skin on your feet so dry that it cracks open?

[ ] Yes

[ ] No

15. Have you ever had an amputation?

[ ] Yes

[ ] No

Total:______/15pts

Scoring Instructions:

Score each positive response as a "1". The greater the score, the greater risk for neuropathy.

Protocol Name from Source:

Feldman, EL, Stevens, MJ, Thomas, PK, Brown, MB, Canal, N & Greene, DA. (1994). A practical two-step quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic neuropathy. Diabetes Care, 17(11), 1281-1289.

Availability:

Publicly available

Personnel and Training Required

None

Equipment Needs

None

Requirements
Requirement CategoryRequired
Major equipment No
Specialized training No
Specialized requirements for biospecimen collection No
Average time of greater than 15 minutes in an unaffected individual No
Mode of Administration

Self-administered questionnaire

Life Stage:

Adult, Senior

Participants:

Participant aged 18 years or older.

Specific Instructions:

None

Selection Rationale

The Michigan Neuropathy Screening Instrument (MNSI) was vetted against several other neuropathy protocols and chosen because it is a relatively well validated, widely used instrument.

Language

English

Standards
StandardNameIDSource
Common Data Elements (CDE) Person Diabetic Neuropathy Assessment Description Text 3070668 CDE Browser
Logical Observation Identifiers Names and Codes (LOINC) Diabetic peripheral neuropathy proto 62795-0 LOINC
Derived Variables

None

Process and Review

The Expert Review Panel #1 reviewed the measures in the Anthropometrics, Diabetes, Physical Activity and Physical Fitness, and Nutrition and Dietary Supplements domains.

Guidance from the ERP includes:

  • No significant changes

Back-compatible: no changes to Data Dictionary

Previous version in Toolkit archive (link)

Source

Feldman, EL, Stevens, MJ, Thomas, PK, Brown, MB, Canal, N & Greene, DA. (1994). A practical two-step quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic neuropathy. Diabetes Care, 17(11), 1281-1289.

General References

American Diabetes Association (ADA). (2014). Standards of medical care in Diabetes-2014. Diabetes Care, 37 (Suppl. 1), S14 - S80.

Protocol ID:

140401

Variables:
Export Variables
Variable NameVariable IDVariable DescriptionVersiondbGaP Mapping
PX140401_Amputation PX140401150000 Have you ever had an amputation? 4 N/A
PX140401_Bed_Covers_Hurt PX140401060000 Does it hurt when the bed covers touch your skin? 4 N/A
PX140401_Burning_Pain PX140401020000 Do you ever have any burning pain in your legs and/or feet? 4 N/A
PX140401_Diagnosed_Diabetic_Neuropathy PX140401090000 Has your doctor ever told you that you have diabetic neuropathy? 4 N/A
PX140401_Feel_Weak_All_Over PX140401100000 Do you feel weak all over most of the time? 4 N/A
PX140401_Feet_Too_Sensitive_To_Touch PX140401030000 Are your feet too sensitive to touch? 4 N/A
PX140401_Legs_Feet_Numb PX140401010000 Are your legs and/or feet numb? 4 N/A
PX140401_Leg_Hurt_When_Walk PX140401120000 Do your legs hurt when you walk? 4 N/A
PX140401_Muscle_Cramps PX140401040000 Do you get muscle cramps in your legs and/or feet? 4 N/A
PX140401_Open_Sore PX140401080000 Have you ever had an open sore on your foot? 4 N/A
PX140401_Prickling_Feelings PX140401050000 Do you ever have any prickling feelings in your legs or feet? 4 N/A
PX140401_Sense_Feet_When_Walking PX140401130000 Are you able to sense your feet when you walk? 4 N/A
PX140401_Skin_Cracks_Open PX140401140000 Is the skin on your feet so dry that it cracks open? 4 N/A
PX140401_Symptoms_Worse_At_Night PX140401110000 Are your symptoms worse at night? 4 N/A
PX140401_Tell_Hot_Water_From_Cold PX140401070000 When you get into the tub or shower, are you able to tell the hot water from the cold water? 4 N/A
Research Domain Information
Measure Name:

Diabetic Peripheral Neuropathy

Release Date:

October 1, 2015

Definition

A questionnaire to determine if a respondent has a history of peripheral neuropathy.

Purpose

Diabetic peripheral neuropathy, also known as distal symmetric polyneuropathy, is a leading complication of both type 1 and type 2 diabetes and is responsible for more than half of all non-traumatic foot amputations in the United States. Incidence of distal symmetric polyneuropathy increases with diabetes duration with up to 50% of those with diabetes having the disease after 25 years (Feldman et al., 1994).

Keywords

Diabetes, polyneuropathy, nerve disease