Protocol - Behavioral Disturbances

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The NPI-Q is a self-administered questionnaire used by informants (e.g., caregivers) to assess neuropsychiatric symptoms of a patient over the previous month and the effect on the patient and caregiver. Twelve domains and cardinal symptoms of each domain are assessed with yes/no responses. Both severity (a 3-point scale) and distress ratings (a 5-point scale) are recorded for each confirmed symptom. The severity scale applies to the effect on the patient, and the distress scale applies to the effect on the caregiver.

Specific Instructions

The NPI-Q is proprietary and copyrighted by Jeffrey L. Cummings, MD. The NPI-Q may be used freely for academic purposes, but there is a fee for commercial use. See this website for details about use of and access to the NPI-Q: http://npitest.net/terms-of-service.html.

Per NPI-Q background and administration documentation, it is recommended that responses to the NPI-Q be reviewed for completeness by a clinician and for clarifying uncertainties after each administration. The first time a subject completes the NPI-Q, it may be useful to verbally review the instructions. In some instances, it may be necessary to conduct the NPI-Q in part or entirely as an interview.

Current age of the patient (not respondent) is essential to this measure


Limited Availability


The NPI-Q is proprietary. See the NPI Test website for access to the NPI-Q.


Personnel and Training Required


Equipment Needs
Requirement CategoryRequired
Major equipment No
Specialized training No
Specialized requirements for biospecimen collection No
Average time of greater than 15 minutes in an unaffected individual No
Mode of Administration

Self-administered questionnaire


Adult, Senior


Adults age 48 years and older with dementia

Selection Rationale

The NPI-Q has been validated with older adults with dementia and is a commonly used neuropsychiatric questionnaire.



Human Phenotype Ontology Behavioral abnormality HP:0000708 HPO
Derived Variables


Process and Review

Not applicable.


Protocol Name from Source

Neuropsychiatric Inventory-Questionnaire (NPI-Q)


Neuropsychiatric Inventory-Questionnaire (NPI-Q)

General References

Geda, Y. E., Roberts, R. O., Knopman, D. S., Petersen, R. C., Christianson, T. J., Pankratz, V. S., .. Rocca, W. A. (2008). Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging: Population-based study. Archives of General Psychiatry, 65(10),1193-1198.

Kaufer, D. I., Cummings, J. L., Ketchel, P., Smith, V., MacMillan, A., Shelley, T., ... DeKosky, S. T. (2000). Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory. Journal of Neuropsychiatry and Clinical Neuroscience, 12(2), 233-239.

Protocol ID


Export Variables
Variable Name Variable IDVariable DescriptiondbGaP Mapping
PX250301000000 Protocol 250301 is a proprietary instrument. N/A
Measure Name

Behavioral Disturbances

Release Date

July 2, 2018


This measure is a questionnaire about behaviors associated with agitation that have occurred since an individual began experiencing memory problems.


To provide a brief assessment of neuropsychiatric symptomatology in routine clinical practice settings. The questionnaire assesses the effect on the patient and the distress caused for the respondent (e.g., the caregiver).


Agitation, behavior, distress, memory, Neuropsychiatric Inventory-Questionnaire, NPI-Q, proprietary, gerontology, aging

Measure Protocols
Protocol ID Protocol Name
250301 Behavioral Disturbances

There are no publications listed for this protocol.