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Research Domain - Geriatrics

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Gill, T.M., et al. A program to prevent functional decline in physically frail, elderly persons who live at home. NEW ENGL J MED, 2002
#250101

National Health and Nutrition Examination Survey (NHANES), Questionnaire (SP) AUDIOMETRY - AUQ Target Group: SPs 1+, 2011
#250201

Neuropsychiatric Inventory-Questionnaire (NPI-Q)
#250301

Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)
#250501

National Health and Nutrition Examination Survey (NHANES), Laboratory Procedures Manual, 2007
#250701

Health, Aging and Body Composition Study (Health ABC), Oral Health and Dental History Questions
#251301

Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly of Boston (MOBILIZE Boston)
#250601

National Institute on Aging?(NIA),?Health and Retirement Study, Family History of Dementia and Longevity, 2016
#250801

Framingham Foot Assessment Clinical Tool
#250901

National Institute on Aging (NIA), Study of Osteoporotic Fractures (SOF), Frailty Index
#251001

Health, Aging, and Body Composition Study (Health ABC), Weight History, Version 1.1a
#251101

Knee injury and Osteoarthritis Outcome Score (KOOS)
#250401

The Life Space Questionnaire
#251201

Brief Resilience Scale (BRS)
#251401

National Health and Nutrition Examination Survey (NHANES), Modified Pocket Smell Test (M-PST), 2013
#251501

Health, Aging, and Body Composition Study (Health ABC), Urinary History
#251601
Additional Relevant Protocols
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Age of Initiation of First Cigarette Use - Adult
Co-sponsored Tobacco Use Supplement to the Current Population Survey, 2010
Alcohol - 30-Day Quantity and Frequency
National Survey on Drug Use and Health (NSDUH), 2015 & National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Epidemiologic Survey on Alcohol and Related Conditions, Wave 1 (NESARC - WAVE 1)/Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV)
Alcohol - Age of First Use
National Survey on Drug Use and Health (NSDUH), 2015
Alcohol - Lifetime Use
National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), Wave 1
Arthritis/Osteoarthritis
A Knee Health Study, The Kellgren-Lawrence Grading Scale, version 2.1, August 2006
Audiogram Hearing Test
National Health and Nutrition Examination Survey (NHANES), Audiometry Protocol, 2015-2016
Balance
Health, Aging and Body Composition (Health ABC) Study, Operations Manual Volume XIII, One Leg Stand, 2007
Cigarette Nicotine Dependence
Fagerstrom Test for Nicotine Dependence, 1991
Cigarette Smoking Status - Adolescent
Population Assessment of Tobacco and Health (PATH) Study Wave 3
Cigarette Smoking Status - Adult
Population Assessment of Tobacco and Health (PATH) Study Wave 1
Clinician-Administered Psychiatric Assessment
Structured Clinical Interview for DSM-5 Disorders - Clinician Version (SCID-5-CV)
Complete Blood Count (CBC)
National Health and Nutrition Examination Survey (NHANES), Laboratory procedures Manual, 2010
Current Environmental Tobacco Smoke Exposure
National Health and Nutrition Examination Survey (NHANES), Family Questionnaire, 2007-2008
Depressive Symptoms - Adult
The Quick Inventory of Depressive Symptoms (QIDS)
Depressive Symptoms - Child
Mood and Feelings Questionnaire (MFQ)
Depressive Symptoms - Depression in Dementia
The Cornell Scale for Depression in Dementia
Depressive Symptoms - Geriatric
Geriatric Depression Scale (GDS)?- Short Form
Exercise Capacity/Six-Minute Walk Test
Six-Minute Walk Test (6MWT)
Fracture History
Study of Osteoporotic Fractures (SOF), History of Fractures Questionnaire & Framingham Osteoporosis Study Fracture Assessment
Global Mental Status Screener - Adult
Montreal Cognitive Assessment (MOCA?)
Global Mental Status Screener - Child
The Ages & Stages Questionnaires?, Third Edition (ASQ-3?)
Global Mental Status Screener - Older Children and Adolescents
Children?s Global Assessment Scale (CGAS)
Grip Strength
National Health and Nutrition Examination Survey (NHANES),?Muscle Strength Procedures Manual, 2013-2014
Height - Knee Height
National Health and Nutrition Examination Survey III (NHANES III), Body Measurements, 1988
Height - Recumbent Length
National Health and Nutrition Examination Survey III (NHANES III), Body Measurements, 1988
Height - Self-Reported Height
National Health and Nutritional Examination Survey (NHANES) Weight History Questionnaire, 2007
Height - Standing Height
National Health and Nutrition Examination Survey (NHANES), Anthropometry Procedures Manual, 2007
History of Stroke - Ischemic Infarction and Hemorrhage
Jackson Heart Study (JHS)
Male Sexual Function
Study for Future Families & International Index of Erectile Function (IIEF)
Neuropathy - Autonomic Assessment - Adult
Survey of Autonomic Symptoms (SAS)
Neuropathy - Clinical Assessment
Charcot-Marie-Tooth Neuropathy Score
Number of Natural Teeth
Health Professionals Follow-Up Study (HPFS), Infant Feeding Practices Study II (IFPS-II), Postnatal Month 12
Parkinsons Disease Symptoms
Movement Disorder Society United Parkinson?s Disease Rating Scale (MDS-UPDRS)
Patterns of Substance Use - Adolescents
Monitoring the Future (MTF), 2015
Patterns of Substance Use - Adults - Binge-Drinking
National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III)
Physical Functioning - Objective
Short Physical Performance Battery
Physical Functioning - Subjective
National Health and Nutrition Examination Survey (NHANES), Sample Person Questionnaire: Physical Functioning Module, 2005-2006
Physical, Social, and Mental Health Functioning (SF-36V2)
SF-36v2 Health Survey
Pulse Oximetry (Rest)
World Health Organization (WHO), Pulse oximetry training manual, 2011
Quality of Life - Adult
Patient-Reported Outcomes Measurement Information System? (PROMIS) 29 Profile, v. 2.0 Adult Profile
Quality of Life - Pediatric
Patient-Reported Outcomes Measurement Information System? (PROMIS) Item Bank, v.1.1, Pediatric Profile 25
Screening and Severity of Substance Use Problems - Adolescents
Treatment Improvement Protocol (TIP) Services, Simple Screening Instrument for Alcohol and Other Drugs (SSI-AOD)
Screening and Severity of Substance Use Problems - Adults - Alcohol - Lifetime
Brief Michigan Alcoholism Screening Test (Brief MAST)
Screening and Severity of Substance Use Problems - Adults - Alcohol - Past 12 Months
Alcohol Use Disorders Identification Test (AUDIT)
Screening and Severity of Substance Use Problems - Adults - Drugs
Drug Abuse Screening Test (DAST-10)
Signs of Essential Tremor
Washington Heights-Inwood Genetic Study of Essential Tremor (WHIGET) Tremor Rating Scale
Sleep Disorders Screener
National Institute of Mental Health (NIMH), Sleep Patterns and Problems?
Spine and Femur Bone Density by Dual-Energy X-ray Absorptiometry
Framingham Osteoporosis Study, Generation 3, Musculoskeletal Exam
Substances - 30-Day Frequency
National Survey on Drug Use and Health (NSDUH), 2015
Substances - Age of First Use
National Survey on Drug Use and Health (NSDUH), 2015
Substances - Lifetime Use
National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III)
Tobacco - Age of Initiation of Use - Adolescent
National Survey on Drug Use and Health (NSDUH), 2008
Total Physical Activity - Comprehensive - Adolescent
Three-Day Physical Activity Recall (3 Day PAR)
Verbal Memory - Adult
Wechsler Memory Scale?, Logical Memory subtest,?Fourth Edition (WMS?-IV)
Verbal Memory - Child
Children?s Memory Scale (CMS), Verbal Memory subscales
Visual Memory - Adult
Wechsler Memory Scale?, Visual Reproductions subtest, Fourth Edition (WMS?-IV)
Visual Memory - Child
Children?s Memory Scale? (CMS), Visual Memory subtest
Weight Loss/Gain
National Health and Nutrition Examination Survey (NHANES), Weight History Questionnaire, 2007
Working Memory - Adult
Wechsler Adult Intelligence Scale?, Digit Span subtest, Fourth Edition (WAIS?-IV)
Working Memory - Child
Children?s Memory Scale (CMS), Attention and Concentration subtests
Release Date:

July 2, 2018; reviewed July 2, 2018

Scope of Domain:
Scope Elements Final Protocols To Toolkit (16)
Arthritis/Chronic Inflammation Knee Injury and Osteoarthritis
Dementia (Parkinson's disease dementia, lewy body dementia, vascular dementia), Alzheimer's Behavioral Disturbances
Cognitive Changes
Depression/Anxiety Depression Symptoms (added two protocols to existing measure)
Falls Falls
Family health history (Longevity) Family History of Dementia and Longevity
Foot Disorders Foot Pain
Frailty Frailty
Involuntary Weight Loss/BMI Change Involuntary Weight Loss
Kidney Cystatin C Assay for Kidney Function
Life Space Life Space
Oral and dental care (tooth decay, gum disease) Dental Issues and Difficulty Chewing
Physical Functioning 400 Meter Walk
Resilience Resilience
Sensory capabilities/Impairment Auditory Perception and Noise Exposure
Smell and Taste
Urinary issues Urinary Incontinence
Sexuality Addressed elsewhere in PhenX Toolkit
Sleep Addressed elsewhere in PhenX Toolkit
Verbal Memory Addressed elsewhere in PhenX Toolkit
Working Group Roster:

WG Members:

Mary Sano, PhD, Chair
Icahn School of Medicine
New York, NY 		Steven Cummings, MD
California Pacific Medical Center
San Francisco, CA
Philip De Jager, MD, PhD, MMSc
Columbia University
New York, NY 		Colin Depp, PhD
University of California, San Diego
San Diego, CA
Jack Guralnik, MD, PhD, MPH
University of Maryland, Baltimore
Baltimore, MD 		Tamara Harris, MD
National Institute on Aging (NIA)
Bethesda, MS
Denise Houston, PhD
Wake Forest University
Winston-Salem, NC 		Claudia Kawas, MD
University of California, Irvine
Irvine, CA
Douglas P. Kiel, MD
Harvard University
Belmont, MA 		Richard Mayeux, MD, MSc
Columbia University
New York, NY

SC Liaison, WG Manager and WG Supervisor:

Lindsay A. Farrer, PhD, SC Liaison
Boston University
Boston, MA 		Lisa Cox, MS, WG Manager
RTI International
Atlanta, GA
Michael Phillips, MS, WG Supervisor
RTI International
Research Triangle Park, NC
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Select Measure Name Protocols
Activities of Daily Living (ADLs) Activities of Daily Living (ADLs)
Auditory Perception and Noise Exposure Auditory Perception and Noise Exposure
Behavioral Disturbances Behavioral Disturbances
Knee Injury and Osteoarthritis Knee Injury and Osteoarthritis
Cognitive Changes Cognitive Changes
Falls Falls
Cystatin C Assay for Kidney Function Cystatin C Assay for Kidney Function
Family History of Dementia and Longevity Family History of Dementia and Longevity
Foot Pain Foot Pain
Frailty Frailty
Involuntary Weight Loss Involuntary Weight Loss
Life Space Life Space
Dental Issues and Difficulty Chewing Dental Issues and Difficulty Chewing
Resilience Psychological Resilience
Smell and Taste Smell and Taste
Urinary Incontinence Urinary Incontinence