Protocol - Knee Injury and Osteoarthritis

Personnel and Training Required

None

Equipment Needs

None

Requirements

Requirement Category	Required
Major equipment	No
Specialized training	No
Specialized requirements for biospecimen collection	No
Average time of greater than 15 minutes in an unaffected individual	No

Mode of Administration

Self-administered questionnaire

Lifestage

Adolescent, Adult, Senior

Participants

Patients 13-79 years of age

Selection Rationale

The KOOS instrument demonstrates good test-retest reliability, content validity and internal consistency with adult and older adult populations.

Language

English

Standards

Standard	Name	ID	Source
Human Phenotype Ontology	Knee osteoarthritis	HP:0005086	HPO
Human Phenotype Ontology	Knee pain	HP:0030839	HPO
caDSR Form	PhenX PX250401 - Knee Injury And Osteoarthritis	6886462	caDSR Form

Derived Variables

None

Process and Review

Not applicable.

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Protocol Name from Source

Knee injury and Osteoarthritis Outcome Score (KOOS)

Source

Roos, E.M., Roos, P.H., Lohmander, L.S., Ekdahl, C., Beynnon, B.D. (1998) Knee injury and Osteoarthritis Outcome Score (KOOS). Development of a self-administered outcome measure. J Orthop Sports Phys Ther, 78(2):88-96

Knee injury and Osteoarthritis Outcome Score (KOOS), English version LK1.0

General References

Ageberg, E., Forssblad, M., Herbertsson, P., & Roos, E. M. (2010). Sex differences in patient-reported outcomes after anterior cruciate ligament reconstruction: Data from the Swedish Knee Ligament Register. American Journal of Sports Medicine, 38, 1334-1342.

Alviar, M. J., Olver, J., Brand, C., Hale, T., & Khan, F. (2011). Do patient-reported outcome measures used in assessing outcomes in rehabilitation after hip and knee arthroplasty capture issues relevant to patients? Results of a systematic review and ICF linking process. Journal of Rehabilitation Medicine: Official Journal of the UEMS European Board of Physical and Rehabilitation Medicine, 43, 374-381.

Bellamy, N., Buchanan, W. W., Goldsmith, C. H., Campbell, J., & Stitt, L. W. (1988). Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. Journal of Rheumatology, 15, 1833-1840.

Collins, N. J., Prinsen, C.A., Christensen, R., Bartels, E.M., Terwee, C.B., Roos, E.M. (2016). Knee Injury and Osteoarthritis Outcome Score (KOOS): systematic review and meta-analysis of measurement properties. Osteoarthritis Cartilage, 24(8): 1317-1329.

Collins, N. J., Misra, D., Felson, D. T., Crossley, K. M., & Roos, E. M. (2011). Measures of knee function: International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form, Knee Injury and Osteoarthritis Outcome Score (KOOS), Knee Injury and Osteoarthritis Outcome Score Physical Function Short Form (KOOS-PS), Knee Outcome Survey Activities of Daily Living Scale (KOS-ADL), Lysholm Knee Scoring Scale, Oxford Knee Score (OKS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Activity Rating Scale (ARS), and Tegner Activity Score (TAS). Arthritis Care and Research;63(Suppl. 11), S208-S228.

Collins, N. J., & Roos, E. M. (2012). Patient-reported outcomes for total hip and knee arthroplasty: commonly used instruments and attributes of a "good" measure. Clinics in Geriatric Medicine, 28, 367-394.

Frobell, R. B., Svensson, E., Gothrick, M., & Roos, E. M. (2008). Self-reported activity level and knee function in amateur football players: The influence of age, gender, history of knee injury and level of competition. Knee Surgery, Sports Traumatology, Arthroscopy, 16, 713-719.

Garratt, A. M., Brealey, S., & Gillespie, W. J. (2004). Patient-assessed health instruments for the knee: A structured review. Rheumatology (Oxford), 43, 1414-1423.

Gudbergsen, H., Bartels, E. M., Krusager, P., Waehrens, E. E., Christensen, R., Danneskiold-Samsoe, B., & Bliddal, H. (2011). Test-retest of computerized health status questionnaires frequently used in the monitoring of knee osteoarthritis: a randomized crossover trial. BMC Musculoskeletal Disorders, 12, 190.

Nilsdotter, A. K., Toksvig-Larsen, S., & Roos, E. M. (2009). A 5 year prospective study of patient-relevant outcomes after total knee replacement. Osteoarthritis Cartilage, 17, 601-606.

Ostenberg, A., Roos, E., Ekdahl, C., & Roos, H. (2000). Physical capacity in female soccer players-does age make a difference? Advances in Physiotherapy, 2, 39-48.

Paradowski, P. T., Bergman, S., Sunden-Lundius, A., Lohmander, L. S., & Roos, E. M. (2006). Knee complaints vary with age and gender in the adult population. Population-based reference data for the Knee injury and Osteoarthritis Outcome Score (KOOS). BMC Musculoskeletal Disorders, 7, 38.

Rodriguez-Merchan, E. C. (2012). Knee instruments and rating scales designed to measure outcomes. Journal of Orthopaedics andTraumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology, 13, 1-6.

Roos, E., Engelhart, L., Ranstam, J., Anderson, A., Irrgang, J., Marx, R., . . . Davis, A. M. (2011). ICRS Recommendation Document: Patient-reported outcome instruments for use in patients with articular cartilage defects. Cartilage, 2, 122-136.

Roos, E. M., & Lohmander, L. S. (2003). Knee injury and Osteoarthritis Outcome Score (KOOS): From joint injury to osteoarthritis. Health and Quality of Life Outcomes, 1, 64.

Roos, E. M., Klassbo, M., & Lohmander, L. S. (1999). WOMAC osteoarthritis index. Reliability, validity, and responsiveness in patients with arthroscopically assessed osteoarthritis. Western Ontario and McMaster Universities. Scandinavian Journal of Rheumatolology, 28, 210-215.

Roos, E. M., Roos, H. P., & Lohmander, L. S. (1999). WOMAC Osteoarthritis Index-Additional dimensions for use in subjects with post-traumatic osteoarthritis of the knee. Western Ontario and McMaster Universities. Osteoarthritis Cartilage, 7, 216-221.

 Wright, R. W. (2009). Knee injury outcomes measures. Journal of the American Academy of Orthopaedic Surgeons, 17, 31-39

Protocol ID

250401

Variables

Export Variables

Variable Name	Variable ID	Variable Description	dbGaP Mapping
PX250401_Knee_Injury_Osteoarthritis_Bend_Fully
	PX250401010500	Can you bend your knee fully?	N/A
PX250401_Knee_Injury_Osteoarthritis_Catch_Hang_Moving
	PX250401010300	Does your knee catch or hang up when moving?	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Ascend_Stairs
	PX250401030200	For each of the following activities please more indicate the degree of difficulty you have experienced in the last week due to your knee. Ascending stairs show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Bathtub
	PX250401031300	For each of the following activities please more indicate the degree of difficulty you have experienced in the last week due to your knee. Getting in/out of bath show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Bending_Floor
	PX250401030500	For each of the following activities please more indicate the degree of difficulty you have experienced in the last week due to your knee. Bending to floor/pick up an object show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Descend_Stairs
	PX250401030100	For each of the following activities please more indicate the degree of difficulty you have experienced in the last week due to your knee. Descending stairs show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Enter_Exit_Car
	PX250401030700	For each of the following activities please more indicate the degree of difficulty you have experienced in the last week due to your knee. Getting in/out of car show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Heavy_Domestic_Duties
	PX250401031600	For each of the following activities please more indicate the degree of difficulty you have experienced in the last week due to your knee. Heavy domestic duties (moving heavy boxes, scrubbing floors, etc.) show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Jumping
	PX250401040300	The questions should be answered thinking of more what degree of difficulty you have experienced during the last week due to your knee. Jumping show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Kneeling
	PX250401040500	The questions should be answered thinking of more what degree of difficulty you have experienced during the last week due to your knee. Kneeling show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Light_Domestic_Duties
	PX250401031700	For each of the following activities please more indicate the degree of difficulty you have experienced in the last week due to your knee. Light domestic duties (cooking, dusting, etc.) show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Lying
	PX250401031200	For each of the following activities please more indicate the degree of difficulty you have experienced in the last week due to your knee. Lying in bed (turning over, maintaining knee position) show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Remove_Stocks_Stockings
	PX250401031100	For each of the following activities please more indicate the degree of difficulty you have experienced in the last week due to your knee. Taking off socks/stockings show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Rising_Bed
	PX250401031000	For each of the following activities please more indicate the degree of difficulty you have experienced in the last week due to your knee. Rising from bed show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Rising_Sitting
	PX250401030300	For each of the following activities please more indicate the degree of difficulty you have experienced in the last week due to your knee. Rising from sitting show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Running
	PX250401040200	The questions should be answered thinking of more what degree of difficulty you have experienced during the last week due to your knee. Running show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Shopping
	PX250401030800	For each of the following activities please more indicate the degree of difficulty you have experienced in the last week due to your knee. Going shopping show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Sitting
	PX250401031400	For each of the following activities please more indicate the degree of difficulty you have experienced in the last week due to your knee. Sitting show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Socks_Stockings
	PX250401030900	For each of the following activities please more indicate the degree of difficulty you have experienced in the last week due to your knee. Putting on socks/stockings show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Squatting
	PX250401040100	The questions should be answered thinking of more what degree of difficulty you have experienced during the last week due to your knee. Squatting show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Standing
	PX250401030400	For each of the following activities please more indicate the degree of difficulty you have experienced in the last week due to your knee. Standing show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Toilet
	PX250401031500	For each of the following activities please more indicate the degree of difficulty you have experienced in the last week due to your knee. Getting on/off toilet show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Twisting_Pivoting
	PX250401040400	The questions should be answered thinking of more what degree of difficulty you have experienced during the last week due to your knee. Twisting/pivoting on your injured knee show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Function_Walking_Flat_Surface
	PX250401030600	For each of the following activities please more indicate the degree of difficulty you have experienced in the last week due to your knee. Walking on flat surface show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Grinding_Clicking_Noise
	PX250401010200	Do you feel grinding, hear clicking or any more other type of noise when your knee moves? show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Pain_Bend_Fully
	PX250401020400	What amount of knee pain have you more experienced the last week during the following activities? Bending knee fully show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Pain_Frequency
	PX250401020100	How often do you experience knee pain?	N/A
PX250401_Knee_Injury_Osteoarthritis_Pain_Night_Bed
	PX250401020700	What amount of knee pain have you more experienced the last week during the following activities? At night while in bed show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Pain_Sitting_Lying
	PX250401020800	What amount of knee pain have you more experienced the last week during the following activities? Sitting or lying show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Pain_Stairs
	PX250401020600	What amount of knee pain have you more experienced the last week during the following activities? Going up or down stairs show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Pain_Standing_Upright
	PX250401020900	What amount of knee pain have you more experienced the last week during the following activities? Standing upright show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Pain_Straighten_Fully
	PX250401020300	What amount of knee pain have you more experienced the last week during the following activities? Straightening knee fully show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Pain_Twisting_Pivoting
	PX250401020200	What amount of knee pain have you more experienced the last week during the following activities? Twisting/pivoting on your knee show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Pain_Walking_Flat_Surface
	PX250401020500	What amount of knee pain have you more experienced the last week during the following activities? Walking on flat surface show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Quality_Life_Awareness
	PX250401050100	How often are you aware of your knee problem?	N/A
PX250401_Knee_Injury_Osteoarthritis_Quality_Life_Change
	PX250401050200	Have you modified your life style to avoid more potentially damaging activities to your knee? show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Quality_Life_Confidence
	PX250401050300	How much are you troubled with lack of more confidence in your knee? show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Quality_Life_Difficulty
	PX250401050400	In general, how much difficulty do you have more with your knee? show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Stiffness_Morning
	PX250401010600	How severe is your knee joint stiffness more after first wakening in the morning? show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Stiffness_Sitting_Lying_Resting
	PX250401010700	How severe is your knee stiffness after more sitting, lying or resting later in the day? show less	N/A
PX250401_Knee_Injury_Osteoarthritis_Straighten_Fully
	PX250401010400	Can you straighten your knee fully?	N/A
PX250401_Knee_Injury_Osteoarthritis_Swelling
	PX250401010100	Do you have swelling in your knee?	N/A

Geriatrics

Measure Name

Knee Injury and Osteoarthritis

Release Date

July 2, 2018

Definition

A self-administered questionnaire to assess the patient's opinion about their knee and associated problems. Intended to be used for knee injury that can result in post-traumatic osteoarthritis (OA) as well as knee OA.

Purpose

Chronic inflammation of the knee or post-traumatic osteoarthritis (OA) can cause physical and emotional distress, result in limitations on functional ability and daily living activities, and can negatively impact an individual's quality of life.

Keywords

swelling, stiffness, joint, pain, standing, recreation, limitations, disability, injury, Knee injury and Osteoarthritis Outcome Score (KOOS), anterior cruciate ligament, ACL, lateral collateral ligament, LCL, cartilage, meniscus, osteoarthritis, physical trauma, sports injury, gerontology, aging

Measure Protocols

Protocol ID	Protocol Name
250401	Knee Injury and Osteoarthritis

Publications

There are no publications listed for this protocol.