Protocol - Left Ventricular Global Longitudinal Strain by Speckle Tracking Echocardiography
Two-dimensional (2D) speckle tracking echocardiography is a quantitative imaging technique that may be used to assess left ventricular function. The motion of speckles in a 2D ultrasound image is tracked, providing an assessment of left ventricular deformation, or strain.
Description of Quantification of Left Ventricular Global Longitudinal Strain by Speckle Tracking Echocardiography
The European Association of Cardiovascular Imaging (EACVI)/American Society of Echocardiography (ASE)/Industry Task Force guidelines for standardizing strain imaging consists of standard definitions, names, abbreviations, formulas, and procedures for calculating physical quantities derived from speckle tracking echocardiography. The guidance provides technical information only, including definitions of the standard quantities that software should report. Task force recommendations are provided alongside each parameter. The guidance provides geometry definitions and strain parameters. Region of interest, segment definitions and views, and segmentation models are covered. An overview of 2D speckle tracking parameters used for strain measurement including velocity, displacement, strain and strain rate, and rotational mechanics is included. Special considerations for strain and strain rate calculations, such as clinically relevant points along strain curves, is provided. Guidance for the calculation of global strain or strain rate is included.
The Sickle Cell Disease Curative Therapies Working Group recommends that one method to measure left ventricular global longitudinal strain by speckle tracking echocardiography be used consistently to monitor study participants. The guidelines note that differences between imaging equipment and software applications from different vendors may result in differences between similar calculations for various technical reasons. Spatial and temporal resolution of acquired images may differ. Software applications employ different tracking techniques, which may differ in accuracy and reliability. Image resolution and overall image quality may produce variability in results.
Personnel and Training Required
Cardiac sonographers are needed to administer the speckle tracking echocardiography. The results of the echocardiogram should be interpreted by a cardiologist.
Echocardiography machine, ultrasound gel
|Specialized requirements for biospecimen collection||No|
|Average time of greater than 15 minutes in an unaffected individual||Yes|
Mode of Administration
Child, Adolescent, Adult
Participants 5 years and older
The standards from the EACVI/ASE/Industry Task Force were selected as the best standardized methodology for determining left ventricular strain by two-dimensional (2D) speckle tracking echocardiography. The recommendations are based on an industry initiative to achieve consensus on a list of standard definitions and naming for 2D speckle tracking clinical parameters.
|caDSR Common Data Elements (CDE)||Echocardiography Left Ventricular Dysfunction Assessment Text||7765166||CDE Browser|
Process and Review
Protocol Name from Source
Voigt, et al. Definitions for a common standard for 2D speckle tracking echocardiography: Consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging. European Heart Journal - Cardiovascular Imaging, 16(1), 1-11.
Voigt, J. U., Pedrizzetti, G., Lysyansky, P., Marwick, T. H., Houle, H., Baumann, R., Pedri, S., Ito, Y., Abe, Y., Metz, S., Song, J. H., Hamilton, J., Sengupta, P. P., Kolias, T. J., d'Hooge, J., Aurigemma, G. P., Thomas, J. D., & Badano, L. P. (2015). Definitions for a common standard for 2D speckle tracking echocardiography: Consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging. Journal of the American Society of Echocardiography, 28(2), 183–193.
Arciniegas Calle, M. C., Sandhu, N. P., Xia, H., Cha, S. S., Pellikka, P. A., Ye, Z., Herrmann, J., & Villarraga, H. R. (2018). Two-dimensional speckle tracking echocardiography predicts early subclinical cardiotoxicity associated with anthracycline-trastuzumab chemotherapy in patients with breast cancer. BMC Cancer, 18(1), 1037.
Nagueh, S. F., Smiseth, O. A., Appleton, C. P., Byrd, B. F., 3rd, Dokainish, H., Edvardsen, T., Flachskampf, F. A., Gillebert, T. C., Klein, A. L., Lancellotti, P., Marino, P., Oh, J. K., Popescu, B. A., & Waggoner, A. D. (2016). Recommendations for the evaluation of left ventricular diastolic function by echocardiography: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Journal of the American Society of Echocardiography, 29(4), 277–314.
Resende, M., Ferrari, T., Araujo, C. G., Vasconcelos, M., Tupinambás, J. T., Dias, R., Barros, F. C., Januário, J. N., Barbosa, M. M., & Nunes, M. (2020). Prognostic value of left ventricular longitudinal strain by speckle-tracking echocardiography in patients with sickle cell disease. International Journal of Cardiovascular Imaging, 36(11), 2145–2153.
Sengupta, S. P., Jaju, R., Nugurwar, A., Caracciolo, G., & Sengupta, P. P. (2012). Left ventricular myocardial performance assessed by 2-dimensional speckle tracking echocardiography in patients with sickle cell crisis. Indian Heart Journal, 64(6), 553–558.
Whipple, N. S., Naik, R. J., Kang, G., Moen, J., Govindaswamy, S. D., Fowler, J. A., Dowdy, J., Penkert, R., Joshi, V. M., & Hankins, J. S. (2018). Ventricular global longitudinal strain is altered in children with sickle cell disease. British Journal of Haematology, 183(5), 796–806.
|Variable Name||Variable ID||Variable Description||dbGaP Mapping|
Left Ventricular Global Longitudinal Strain
August 16, 2021
Left ventricular global longitudinal strain measures the shortening of the length of the heart during contraction.
Left ventricular global longitudinal strain is a biomarker for a range of conditions, including left ventricular hypertrophy, diastolic dysfunction, valvular disease, ischemic heart disease, and cardiomyopathies, as well as for detecting subclinical myocardial dysfunction in patients who are undergoing chemotherapy or have heart valve diseases. Studies in patients with sickle cell disease have shown that higher left ventricular global longitudinal strain values are a predictor of adverse outcomes including all-cause mortality, severe pain episodes, acute chest syndrome, and hospitalization due to complications.
Sickle Cell Disease Curative Therapies, European Association of Cardiovascular Imaging (EACVI), American Society of Echocardiography (ASE), left ventricular hypertrophy, diastolic dysfunction, valvular disease, heart failure, myocardial, echocardiogram, echocardiography, speckle tracking
|Protocol ID||Protocol Name|
|850201||Left Ventricular Global Longitudinal Strain by Speckle Tracking Echocardiography|
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