Protocol - Perimenopausal Symptoms
The Greene Climacteric Scale is a twenty-one–item, self-administered questionnaire that captures the symptoms that occur in perimenopause. Each item is rated on a Likert-style scale from “Not at all” (0) to “Extremely” (3). Scores can be derived in six symptom categories: Psychological, Anxiety, Depressed Mood, Vasomotor, Somatic, and Sexuality.
The Sickle Cell Disease Genitourinary Working Group notes some questions in this assessment are sensitive. Investigators should provide a private space for completing assessments and to be prepared to offer appropriate support.
The Greene Climacteric Scale
Please indicate the extent to which you are bothered at the moment by any of these symptoms by placing a tick in the appropriate box.
Not at all
Quite a bit
Psychological (P), sum items 1-11 = __________
Somatic (S), sum items 12-18 = _____
Vasomotor (V), sum items 19-20 = _____
Anxiety (A), sum items 1-6 = ______
Depressed Mood (D), sum items 7-11 = ______
Sexuality, item 21 = ______
Personnel and Training Required
|Specialized requirements for biospecimen collection||No|
|Average time of greater than 15 minutes in an unaffected individual||No|
Mode of Administration
Adult females who are perimenopausal
The Greene Climacteric Scale is a brief, validated, self-administered scale that is easy to use and score.
Process and Review
Protocol Name from Source
The Greene Climacteric Scale
Greene J. G. (1998). Constructing a standard climacteric scale. Maturitas, 29(1), 25–31. https://doi.org/10.1016/S0378-5122(98)00025-5
Carpenter, J. S., Sheng, Y., Pike, C., Elomba, C. D., Alwine, J. S., Chen, C. X., & Tisdale, J. E. (2022). Correlates of palpitations during menopause: A scoping review. Women’s Health, 18. https://doi.org/10.1177/17455057221112267
Sourouni, M., Zangger, M., Honermann, L., Foth, D., & Stute, P. (2021). Assessment of the climacteric syndrome: A narrative review. Archives of Gynecology and Obstetrics, 304(4), 855–862. https://doi.org/10.1007/s00404-021-06139-y
|Variable Name||Variable ID||Variable Description||dbGaP Mapping|
|PX880401050000||Attacks of panic||N/A|
|PX880401060000||Difficulty in concentrating||N/A|
|PX880401030000||Difficulty in sleeping||N/A|
|PX880401120000||Feeling dizzy or faint||N/A|
|PX880401020000||Feeling tense or nervous||N/A|
|PX880401070000||Feeling tired or lacking in energy||N/A|
|PX880401090000||Feeling unhappy or depressed||N/A|
|PX880401010000||Heart beating quickly or strongly||N/A|
|PX880401170000||Loss of feeling in hands or feet||N/A|
|PX880401080000||Loss of interest in most things||N/A|
|PX880401210000||Loss of interest in sex||N/A|
|PX880401160000||Muscle and joint pains||N/A|
|PX880401140000||Parts of body feel numb or tingling||N/A|
|PX880401130000||Pressure or tightness in head or body||N/A|
|PX880401200000||Sweating at night||N/A|
August 15, 2023
Perimenopause is defined as the period before the occurrence of menopause.
The onset of menopause is associated with variety of physical symptoms (e.g., sleep disruption, low energy, chills) that can impact quality of life. Certain diseases and conditions, including sickle cell disease and autoimmune diseases, are risk factors for early and premature menopause.
perimenopausal symptoms, climacteric symptoms, menopause, sexual, psychology, anxiety, depression, perimenopause, quality of life
|Protocol ID||Protocol Name|
There are no publications listed for this protocol.