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Pediatric Imaging, Neurocognition, and Genetics

Study Name Pediatric Imaging, Neurocognition, and Genetics
Study Acronym PING
Funding Agency NICHD NIH HHS,NIGMS NIH HHS,NIDA NIH HHS
Primary Research Focus Anxiety is a risk factor for many adverse neuropsychiatric and socioeconomic outcomes, and has been linked to functional and structural changes in the ventromedial prefrontal cortex (VMPFC). However, the nature of these differences, as well as how they develop in children and adolescents, remains poorly understood. More effective interventions to minimize the negative consequences of anxiety require better understanding of its neurobiology in children. Recent research suggests that structural imaging studies may benefit from clearly delineating between cortical surface area and thickness when examining these associations, as these distinct cortical phenotypes are influenced by different cellular mechanisms and genetic factors. The present study examined relationships between cortical surface area and thickness of the VMPFC and a self-report measure of anxiety (SCARED-R) in 287 youths aged 7–20 years from the Pediatric Imaging, Neurocognition, and Genetics (PING) study.
Study Design Name
Number Participants >1000
Study Website http://pingstudy.ucsd.edu/
Protocol Ids 121301
Grant Number R01 GM104400,R01 HD061414,RC2 DA029475
Citation Link https://www.ncbi.nlm.nih.gov/pubmed/26183468