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Protocol - Parkinsons Disease Symptoms

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Description:

The Movement Disorder Society United Parkinson’s Disease Rating Scale (MDS-UPDRS) is an examiner-administered test that includes four subscales: non-motor experiences of daily living (13 items), motor experiences of daily living (13 items), motor examination (33 scores based on 18 items, several with right, left, or other body distribution scores), and motor complications (6 items). Each item is scored on a 5-point scale: 0 = normal, 1 = slight, 2 = mild, 3 = moderate, and 4 = severe. All items are summed together to give a total score, with higher scores indicating greater disability.

Protocol:

Summary of the Movement Disorders Society United Parkinson’s Disease Rating Scale (MDS-UPDRS)

The Movement Disorder Society United Parkinson’s Disease Rating Scale (MDS-UPDRS) is an examiner-administered test that includes four subscales: non-motor experiences of daily living (13 items), motor experiences of daily living (13 items), motor examination (33 scores based on 18 items, several with right, left or other body distribution scores),and motor complications (6 items). Each item is scored on a five point scale: 0 = normal; 1 = slight; 2 = mild; 3 = moderate; and 4 = severe. All items are summed together to give a total score, with higher scores indicating greater disability.

The Movement Disorder Society United Parkinson’s Disease Rating Scale (MDS-UPDRS) is a proprietary instrument and administration (with the exception of personal use) requires a license from the International Parkinson Movement Disorder Society.

Protocol Name from Source:

Movement Disorder Society United Parkinson’s Disease Rating Scale (MDS-UPDRS)

Availability:

Proprietary

Personnel and Training Required

The interviewer must be trained to and found competent to conduct motor examinations, as well as be competent to recognize the impact of comorbidities (such as stroke, arthritis, etc.) on motor movements. Additionally, the interviewer must be trained and found competent in the recognition of motor movements and ratings listed in this protocol, such as the signs and degree of tremor and rigidity and the presence of bradykinesia/hypokinesia.

Equipment Needs

None

Requirements
Requirement CategoryRequired
Major equipment No
Specialized training Yes
Specialized requirements for biospecimen collection No
Average time of greater than 15 minutes in an unaffected individual Yes
Mode of Administration

Physical Examination

Life Stage:

Adult, Senior

Participants:

Adult, aged 18 or older

Specific Instructions:

The Movement Disorder Society United Parkinson’s Disease Rating Scale (MDS-UPDRS) is a proprietary instrument and administration (with the exception of personal use) requires a license from the International Parkinson Movement Disorder Society.

Selection Rationale

The Movement Disorders Society United Parkinson’s Disease Rating Scale (MDS-UPDRS) was selected because it is the standard, validated protocol that is the most-widely used method to follow the progression of Parkinson’s disease over time.

Language

English

Standards
StandardNameIDSource
Common Data Elements (CDE) Person Parkinson's Disease Assessment Score 3076084 CDE Browser
Logical Observation Identifiers Names and Codes (LOINC) Parkinsonian proto 62757-0 LOINC
Derived Variables

None

Process and Review

Expert Review Panel 4 (ERP 4) reviewed the measures in the Neurology, Psychiatric, and Psychosocial domains.

Guidance from ERP 4 included the following:

· Changed measure name

· Updated protocol

· Created new data dictionary

Previous version in Toolkit archive (link)

Source

Goetz, C. G., Tilley, B .C., Shaftman, S. R., Stebbins, G. T., Fahn, S., Martinez-Martin, P., Poewe, W., Sampaio, C., Stern, M. B., Dodel, R., Dubois, B., Holloway, R., Jankovic, J., Kulisevsky, J., Lang, A. E., Lees, A., Leurgans, S., LeWitt, P. A., Nyenhuis, D., Olanow, C. W., Rascol, O., Schrag, A., Teresi, J. A., van Hilten, J. J., & LaPelle, N.; Movement Disorder Society UPDRS Revision Task Force. (2008). Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results. Movement Disorders, 23(15), 2129-2170.

The Movement Disorder Society United Parkinson’s Disease Rating Scale (MDS-UPDRS) is a proprietary instrument and administration (with the exception of personal use) requires a license from the International Parkinson Movement Disorder Society.

General References

Aminoff, M. J., Greenberg, D. A., & Simon, R. P. (2005). Clinical neurology (6th ed.). New York: Lange/McGraw-Hill Medical.

Fahn, S., & Elton, R. L.; UPDRS Program Members. (1987). Unified Parkinson’s Disease Rating Scale. In S. Fahn, C. D. Marsden, M. Goldstein, D. B. Calne (Eds.). Recent developments in Parkinson’s disease, Vol 2. Florham Park; NJ: Macmillan Healthcare Information.

Goetz, C. G., Fahn, S., Martinez-Martin, P., Poewe, W., Sampaio, C., Stebbins, G. T., Stern, M. B., Tilley, B. C., Dodel, R., Dubois, B., Holloway, R., Jankovic, J., Kulisevsky, J., Lang, A. E., Lees, A., Leurgans, S., LeWitt, P. A., Nyenhuis, D., Olanow, C. W., Rascol, O., Schrag, A., Teresi, J. A., Van Hilten, J. J., & LaPelle, N. (2007). Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): Process, format, and clinimetric testing plan. Movement Disorders, 22(1), 41-47.

Goetz, C. G., Stebbins, G. T., Chmura, T. A., Fahn, S., Poewe, W., & Tanner, C. M. (2010). Teaching program for the Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale: (MDS-UPDRS). Movement Disorders, 25(9), 1190-1194.

Hentz, J. G., Mehta, S. H., Shill, H. A., Driver-Dunckley, E., Beach, T. G., & Adler, C. H. (2015). Simplified conversion method for Unified Parkinson’s Disease Rating Scale motor examinations. Movement Disorders, 30(14), 1967-1970.

Jain, S., Himali, J., Beiser, A., Ton, T.G., Kelly-Hayes, M., Biggs, M. L., Delaney, J. A., Rosano, C., Seshadri, S., & Frank, S. A. (2015). Validation of secondary data sources to identify Parkinson disease against clinical diagnostic criteria. American Journal of Epidemiology 181(3), 185-190.

Protocol ID:

130102

Variables:
Export Variables
Variable NameVariable IDVariable DescriptionVersiondbGaP Mapping
Research Domain Information
Measure Name:

Parkinsons Disease Symptoms

Release Date:

November 28, 2017

Definition

A physical examination to assess parkinsonism symptoms, including resting tremor, resistance to movement, slowed voluntary and automatic movement, and abnormal gait and posture.

Purpose

This measure is used to screen an individual for the symptoms of parkinsonism. Parkinsonism occurs in about 0.2% of the population and the risk increases with age. Parkinsonism can be caused by genetics, vascular disease, certain medications, and environmental contaminants such as manganese dust, carbon monoxide, or pesticides (Aminoff et al., 2005).

Keywords

Neurology, parkinsonism, Parkinson’s disease, movement disorders, ataxia, tremor, gait, posture