Protocol - Scale of Developmental Domains of Early Childhood

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The Mullen Scales of Early Learning includes five scales that provide information on an infant’s or child’s cognitive and motor ability, as well as assess, a child’s readiness for school. The scales included in this instrument are: Gross Motor (0-33 months only), Fine Motor, Visual Reception, Expressive Language, and Receptive Language. The latter four are combined to generate an Early Learning Composite, a measure of cognitive functioning.

Specific Instructions

The Mullen Scales of Early Learning is a proprietary instrument with an approximate cost of $870 to purchase the entire kit (the kit is recommended). The instrument may be purchased from Pearson at the following website. www.pearsonclinical.com.

The Rare Genetic Conditions Working Group (WG) suggests the information obtained from the Mullen Scales of Early Learning be interpreted by individuals with a doctorate in psychology, education, child development, or a related field. The WG also notes the time to administer this instrument will vary from approximately 15-60 minutes, depending upon the child’s age, with less time needed for younger children.


Limited Availability


The Mullen Scales of Early Learning is a proprietary instrument of Pearson and can be obtained through the website below. The instrument is sold as a kit which contains manipulatives and a list of items the examiner will need to furnish. Additionally portions of the kit are sold separately.

An investigator can choose to have an individual take all or some of the subscales without affecting the accuracy of the instrument. Also, there is no standard order in which the subscales have to be administered.

The Mullen Scales of Early Learning can be scored manually or via the Mullen ASSIST™ computer software. The below website, contains information on both scoring methods.

Additionally, per the below website, the use of the Mullen Scales of Early Learning along with the Vineland Social-Emotional Early Childhood Scales to assess all required areas for early childhood evaluation is noted.


Personnel and Training Required

The interviewer should be trained and qualified to conduct personal interviews with individuals from the general population.

Equipment Needs

The interviewer will need a copy of the test protocol, testing kit manipulatives, and the scoring instructions.

Requirement CategoryRequired
Major equipment No
Specialized training Yes
Specialized requirements for biospecimen collection No
Average time of greater than 15 minutes in an unaffected individual Yes
Mode of Administration

Interviewer-administered evaluation


Infant, Toddler, Child


Individuals from birth to 68 months (i.e., 5 years and 8 months).

Selection Rationale

Although the Mullen Scales of Early Learning is a proprietary instrument, the Rare Genetic Conditions Working Group selected this instrument because of the following:

1) the test "has strong psychometric properties and has been used with a variety of populations including children with TBI" (McCauley et al., 2012)

2) this instrument is included as a supplemental classification in the National Institute of Neurological Disorders and Stroke (NINDS) Common Data Elements

3) rare conditions are often associated with global developmental delay (GDD) and intellectual disability (ID). GDD is often used as a proxy for ID in children too young for IQ testing; however, GDD is not defined uniformly across clinical or research entities. The Mullen Scales provide a standardized robust method for quantifying cognitive functioning in infants and young children.



Human Phenotype Ontology Specific learning disability HP:0001328 HPO
Derived Variables


Process and Review

Not applicable.

Protocol Name from Source

Mullen Scales of Early Learning


The Mullen Scales of Early Learning is a proprietary instrument of Pearson and can be obtained through:


Attn: Customer Service

P.O. Box 599700

San Antonio, TX 78259

P: 800.627.7271 E-mail: ClinicalCustomerSupport@Pearson.com

Mullen Scales of Early Learning: AGS Edition (MSEL:AGS)

General References

Humphrey, A., MacLean, C., Ploubidis, G. B., Granader, Y., Clifford, M., Haslop, M., Bolton, P. F.; Tuberous Sclerosis 2000 Study Group. (2014). Intellectual development before and after the onset of infantile spasms: A controlled prospective longitudinal study in tuberous sclerosis. Epilepsia, 55(1), 108-116. doi:10.1111/epi.12484.

Keenan, H., Hooper, S., Wetherington, C., Nocera, M., & Runyan, D. (2007). Neurodevelopmental consequences of early traumatic brain injury in 3-year-old children. Pediatrics, 119, e616-e623.

Milner, K. M., Craig, E. E., Thompson, R. J., Veltman, M. W., Thomas, N. S., Roberts, S., Bolton, P. F. (2005). Prader-Willi syndrome: Intellectual abilities and behavioural features by genetic subtype. Journal of Child Psychology and Psychiatry,46(10), 1089-1096.

Mirrett, P. L., Bailey, D. B., Jr., Roberts, J. E., & Hatton. D. D. (2004). Developmental screening and detection of developmental delays in infants and toddlers with fragile X syndrome. Journal of Developmental and Behavioral Pediatrics, 25(1), 21-27.

Mullen, E. (1995). Mullen Scales of Early Learning. Circle Pines, MN: American Guidance Service.

Spurling Jeste, S., Wu, J. Y., Senturk, D., Varcin, K., Ko, J., McCarthy, B., Shimizu, C., Dies, K., Vogel-Farley, V., Sahin, M., & Nelson, C. A., III. (2014). Early developmental trajectories associated with ASD in infants with tuberous sclerosis complex. Neurology, 83(2), 160-168.

Protocol ID


Export Variables
Variable Name Variable IDVariable DescriptiondbGaP Mapping
PX221401000000 Protocol 221401 - proprietary. Check DCW for more
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Rare Genetic Conditions
Measure Name

Scale of Developmental Domains of Early Childhood

Release Date

April 30, 2015


A protocol to assess individual domains of an infant’s or child’s cognitive and motor ability that generates an Early Learning Composite that is presented as a measure of overall cognitive functioning.


This measure can be used to assess an infant’s or child’s development. Standardized T-scores can be used to identify children with atypical development and monitor the developmental trajectory of children in research studies. Information from this measure can be used to determine if there is a need for education or health services.


intellectual disability, Developmental Delay, Learning Disability, autism, autism spectrum disorder, cerebral palsy, childhood, Infant, toddler, Mullen Scales of Early Learning, proprietary

Measure Protocols
Protocol ID Protocol Name
221401 Scale of Developmental Domains of Early Childhood

There are no publications listed for this protocol.