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Protocol - Vitamin D

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Description:

Any methodology that uses the appropriate National Institute of Standards and Technology (NIST) standard reference material and whose use is monitored by participation in the Vitamin D External Quality Assessment Scheme (DEQAS), can be used to quantify vitamin D exposure.

Protocol:

All bioassays that follow the guidelines present in the Description of Protocol are equally valid, and the data collected can be compared across studies.

Protocol Name from Source:

Vitamin D External Quality Assessment Scheme (DEQAS)

Availability:

Publicly available

Personnel and Training Required

Personnel and required training will depend on Vitamin D protocol selected.

Equipment Needs

Equipment needed will depend on Vitamin D protocol selected.

Requirements
Requirement CategoryRequired
Major equipment No
Specialized training No
Specialized requirements for biospecimen collection No
Average time of greater than 15 minutes in an unaffected individual No
Mode of Administration

Bioassay

Life Stage:

Infant, Toddler, Child, Adolescent, Adult, Senior, Pregnancy

Participants:

All ages, but most important for infants and the elderly

Specific Instructions:

None

Selection Rationale

The PhenX Working Group selected this protocol because two recent systematic evidence-based reviews suggest that serum 25 hydroxy vitamin D is the best biomarker for vitamin D exposure and captures exposure levels from both diet and sunlight.

Language

English

Standards
StandardNameIDSource
Common Data Elements (CDE) Person Serum Vitamin D Level Number 2946961 CDE Browser
Logical Observation Identifiers Names and Codes (LOINC) PhenX - vitamin D protocol 62288-6 LOINC
Derived Variables

None

Process and Review

The Expert Review Panel #1 reviewed the measures in the Anthropometrics, Diabetes, Physical Activity and Physical Fitness, and Nutrition and Dietary Supplements domains.

Guidance from the ERP includes:

• No significant changes to measure

Back-compatible: no changes to Data Dictionary

Previous version in Toolkit archive (link)

Source

National Institute of Standards and Technology (NIST)

Vitamin D External Quality Assessment Scheme (DEQAS)

General References

None

Protocol ID:

51101

Variables:
Export Variables
Variable NameVariable IDVariable DescriptionVersiondbGaP Mapping
PX051101_VitaminD_Collection_NanogramsPerLiter PX051101010100 Vitamin D Concentration in ng/L 4 Variable Mapping
Research Domain Information
Measure Name:

Vitamin D

Release Date:

October 1, 2015

Definition

A measure to assess serum vitamin D.

Purpose

Vitamin D functions as a hormone and is one of the most important biological regulators of calcium metabolism, in conjunction with parathyroid hormone and calcitonin. The measurement of 25(OH)D (referred to as the vitamin D assay) is becoming increasingly important in managing patients with various disorders of calcium metabolism associated with rickets, neonatal hypocalcemia, pregnancy, nutritional and renal osteodystrophy, hypoparathyroidism, and postmenopausal osteoporosis.

Keywords

Nutrition and Dietary Supplements, calcitriol, calcium metabolism, Rickets, hypocalcemia, osteodystrophy, hypoparathyroidism, osteoporosis, DEQAS