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Protocol - Family History - Multiple Mental Disorders

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Description:

The Family Interview for Genetic Studies (FIGS) is a tool used by a trained interviewer to collect information about biological relatives of the subject who has a mental disorder. The interview is conducted with the relatives themselves and not through the subject. There are three parts to the FIGS. The General Screening Questions gather general information about all known relatives. The Face Sheet is completed for each of the first-degree relatives and any affected relatives. There are various Symptom Checklists, one for each mental disorder: depression, mania, alcohol/drug abuse, psychosis, and paranoid/schizoid/schizotypal personality.

Specific Instructions:

A baseline assessment of this measure is an interview of a parent and the patient. The optimal approach is to directly interview all available family members, at least out to second-degree relatives. It is important to gather this information from relatives because it can be difficult to rely on information obtained directly from the ill person. If not all relatives can be directly interviewed, one relative may be interviewed about all others.

Protocol:

FAMILY INTERVIEW FOR GENETIC STUDIES

FIGS: FACE SHEET

(FIGS)

Interview date:

- -

Month

Day

Year

Family last name:

Family ID number:

Informant name:

____________________ ____________________ ____________________
First MI Last

Informant ID:

Person being described name:

____________________ ____________________ ____________________
First MI Last

Person being described ID:

Relationship to informant:

____________________________________________________________

Birthdate of person described, if known:

- -

Month

Day

Year

Is person described living?

0[ ]No

1[ ]Yes

9[ ]Unknown

Age and Year when last seen or known about, or died:

in

Age

year

If deceased, cause of death::

____________________________________________________________

Suicide?

0[ ]No

1[ ]Yes

9[ ]Unknown

INTERVIEWER: Refer to General Screening Questions if necessary.

1. (Probe: has he/she had any psychiatric or personality problems like those we mentioned earlier?)

0[ ]No

1[ ]Yes

9[ ]Unknown

Write Narrative:









FIGS: OTHER DISORDERS

1. Indicate any disorder not in the checklists and complete questions 1.a-f for the disorder.

Specify: ________________________________________________________

________________________________________________________________

________________________________________________________________

1.a) Code and describe professional treatment:

0[ ]None

1[ ]Inpatient: _____________________________________________________

2[ ]Outpatient: ___________________________________________________

3[ ]ECT: __________________________________________________________

4[ ]Medication: ___________________________________________________

9[ ]Unknown

1.b) Age of onset:

Age

1.c) Number of episodes:

Episodes

1.d) Duration of longest episode in weeks:

Weeks

1.e) Rate and code impairment or incapacitation:

0[ ]None

1[ ]Impaired

2[ ]Incapacitated

9[ ]Unknown

1.f) Interviewer judgement on reliability of this information:

1[ ]Good

2[ ]Fair

3[ ]Poor



FIGS: GENERAL SCREENING QUESTIONS

Interview date:

- -

Month

Day

Year

Family last name:

Family ID number:

Informant name:

____________________ ____________________ ____________________
First MI Last

Informant ID:

INTERVIEWER: Before you begin, you need to generate or obtain a pedigree on which to record all of the responses to the following General Screening Questions. (See FIGS Manual for details.)

Step 1:Let’s go over your family tree. (Include spouse and his/her parents and siblings, offspring, parents, siblings, aunts, uncles, cousins, grandparents, as well as any other relatives the informant can recall.)
Step 2: Now I am asking you to keep in mind all those in your family tree as I go through this list of questions. (Note all positive responses on the pedigree.)
    [ ] Was anyone adopted?
    [ ] Was anyone mentally retarded?
Did anyone:
    [ ] Have problems with their nerves or emotions? Take medicine or see a doctor for it? Take lithium?
    [ ] Feel very low for a couple of weeks or more, or have a diagnosis of depression?
    [ ] Attempt or complete suicide?
    [ ] Seem overexcited (or manic) day and night, or have a diagnosis of mania?
    [ ] Have visions, hear voices, or have beliefs that seem strange or unreal?
    [ ] Have unusual or bizarre behavior, or have a diagnosis of schizophrenia?
    [ ] Have trouble with the police, with completing school, or with keeping a job?
    [ ] Have alcohol or drug use that caused problems (with health, family, job, or police)? Go to AA or NA, or have treatment for this?
    [ ] (Was anyone) hospitalized for psychiatric problems, or for drug or alcohol problems?
    [ ] Have inherited medical diseases such as Huntington’s disease or seizure disorder or any other disorders of the brain or nervous system?
    [ ] (Did anyone) have few friends, or seem to be a loner?
    [ ] (Did anyone) seem odd or eccentric in behavior or appearance?
    [ ] (Was anyone) extremely jealous, or suspicious, or believe in magic, or see special meanings in things that no one else saw?
Step 3:Complete a Face Sheet for each of the informant’s first-degree relatives and spouse. If he/she knows well other affected relatives, also complete a Face Sheet for them. In addition, for each of these given a positive response in the General Screening, complete the symptom checklist for any suspected: Depression/Mania, Alcohol/Drug Abuse, Psychosis, or Paranoid/Schizoid/Schizotypal Personality.

FIGS: DEPRESSION CHECKLIST

Interview date:

- -

Month

Day

Year

Family last name:

Family ID number:

Informant name:

____________________ ____________________ ____________________
First MI Last

Informant ID:

Person being described name:

____________________ ____________________ ____________________
First MI Last

Person being described ID:

Code for a single episode (best recalled, worst episode if possible).

1. During depression…

1.a) …was he/she depressed most of the day, nearly every day, for as long as a week or more?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.b) …did he/she lose interest in things or become unable to enjoy most things, for as long as a week?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.c) …did he/she have a change in appetite or weight without trying to?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.d) …did he/she have a change in sleep patterns (either too much or too little)?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.e) …did he/she become unable to work, go to school, or take care of household responsibilities?

0[ ]No

1[ ]Yes

9[ ]Unknown

If Yes: Describe: __________________________________________________

If No: Discontinue this checklist.

1.f) …did he/she move or speak more slowly than usual?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.g) …did he/she pace or wring his/her hands?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.h) …did he/she have less energy or feel tired out?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.i) …did he/she feel guilty, worthless or blame himself/herself?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.j) …did he/she have trouble concentrating or making decisions?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.k) …did he/she talk of death or suicide? Or try suicide?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.l) …did he/she have visions, or hear voices, or have beliefs or behavior that seem strange or unusual, at the same time as (symptoms above)? (If YES, complete a Psychosis Checklist after this one.)

0[ ]No

1[ ]Yes

9[ ]Unknown

2. Code and describe professional treatment:

0[ ]None

1[ ]Inpatient: ____________________________________________________

2[ ]Outpatient: __________________________________________________

3[ ]ECT: _________________________________________________________

4[ ]Medication: __________________________________________________

9[ ]Unknown

3.) Age of onset:

Age

4.) Number of episodes:

Episodes

5.) Duration of longest episode in weeks:

Weeks

6. Rate and code impairment or incapacitation:

0[ ]None

1[ ]Modified RDC Impairment

2[ ]Modified RDC Incapacitation

3[ ]RDC Minor Role Dysfunction

4[ ]Change from previous functioning

9[ ]Unknown

7. Interviewer judgement on reliability of this information:

1[ ]Good

2[ ]Fair

3[ ]Poor



FIGS: MANIA CHECKLIST

Interview date:

- -

Month

Day

Year

Family last name:

Family ID number:

Informant name:

____________________ ____________________ ____________________
First MI Last

Informant ID:

Person being described name:

____________________ ____________________ ____________________
First MI Last

Person being described ID:

1. For most of the time day and night over several days, did he/she (more than usual)…

1.a) …seem too happy/high/excited?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.b) …become so excited or agitated it was impossible to converse with him/her?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.c) …act very irritable or angry?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.d) …need less sleep without feeling tired?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.e) …show poor judgement (e.g., spending sprees, sexual indiscretions?)

0[ ]No

1[ ]Yes

9[ ]Unknown

If Yes: Describe: __________________________________________________

If No: Discontinue this checklist.

1.f) …behave in such a way as to cause difficulty for those around him/her (obnoxious/manipulative)?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.g) …feel that he/she had special gifts or powers?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.h) …become more talkative than usual?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.i) …jump from one idea to another?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.j) …become easily distracted?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.k) …get involved in too many activities at work or school?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.l) …have visions? hear voices? have beliefs or behavior that seem strange or unusual? at the same time as (above symptoms)? (If YES, complete a Psychosis Checklist after this one.)

0[ ]No

1[ ]Yes

9[ ]Unknown

2. Code and describe professional treatment:

0[ ]None

1[ ]Inpatient: ____________________________________________________

2[ ]Outpatient: __________________________________________________

3[ ]ECT: _________________________________________________________

4[ ]Medication: __________________________________________________

9[ ]Unknown

3.) Age of onset:

Age

4.) Number of episodes:

Episodes

5.) Duration of longest episode in weeks:

Weeks

6. Rate and code impairment or incapacitation:

0[ ]None

1[ ]Impaired

2[ ]Incapacitated

9[ ]Unknown

7. Interviewer judgement on reliability of this information:

1[ ]Good

2[ ]Fair

3[ ]Poor



FIGS: ALCOHOL & DRUG ABUSE CHECKLIST

Interview date:

- -

Month

Day

Year

Family last name:

Family ID number:

Informant name:

____________________ ____________________ ____________________
First MI Last

Informant ID:

Person being described name:

____________________ ____________________ ____________________
First MI Last

Person being described ID:

ALCOHOLISM

Code for a single episode (best recalled, worst episode if possible).

1. Because of drinking, did he/she ever have problems such as…

1.a) …being unable to stop or cut down on drinking?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.b) …spending a lot of time drinking or being hung over?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.c) …being unable to work, go to school, or take care of household responsibilities?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.d) …being high from drinking when he/she could get hurt?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.e) …accidental injuries?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.f) …reducing or giving up important activities?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.g) …objections from the family or friends, at work or school?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.h) …legal problems more than once (DWIs, arrests)?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.i) …blackouts more than once?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.j) …binges or benders more than once?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.k) …physical health problems (liver disease, pancreatitis)?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.l) …emotional or psychological problems (uninterested, depressed, suspicious/paranoid, having strange ideas)?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.m) …withdrawal symptoms (shakes, seizures/convulsions, DTs)?

0[ ]No

1[ ]Yes

9[ ]Unknown

2. Did he/she go to AA or have any kind of treatment? (Code and describe all that apply)

0[ ]None

1[ ]Inpatient: ____________________________________________________

2[ ]Outpatient: __________________________________________________

3[ ]AA or other self-help: _________________________________________

4[ ]Medication: _________________________________________________

9[ ]Unknown

Describe details and/or other treatment: ________________________________

________________________________________________________________

________________________________________________________________

3. Does he/she currently have a problem with alcohol?

0[ ]No

1[ ]Yes

9[ ]Unknown

4. Record age he/she began to have alcohol-related problems.

Ons Age

5. Record age he/she stopped drinking heavily.

Rec Age

DRUG ABUSE/DEPENDENCE

6. Which drugs did he/she have trouble with?

Specify: ________________________________________________________________________________________________________________________

7. Because of his/her drug use, did he/she have…

7.a) … physical health problems (hepatitis, overdose, withdrawal symptoms, accidental injuries)?

0[ ]No

1[ ]Yes

9[ ]Unknown

7.b) … emotional or psychological problems (uninterested, depressed, suspicious/paranoid, having strange ideas)?

0[ ]No

1[ ]Yes

9[ ]Unknown

7.c) … legal problems (arrests for possessing, selling, or stealing drugs)?

0[ ]No

1[ ]Yes

9[ ]Unknown

7.d) … problems with family or friends?

0[ ]No

1[ ]Yes

9[ ]Unknown

7.e) … troubles at work or school?

0[ ]No

1[ ]Yes

9[ ]Unknown

8. Did he/she go to NA or have any kind of treatment? (Code and describe all that apply)

0[ ]None

1[ ]Inpatient: ___________________________________________________

2[ ]Outpatient: _________________________________________________

3[ ]NA or other self-help: ________________________________________

4[ ]Medication: _________________________________________________

9[ ]Unknown

Describe details and/or other treatment: _________________________

________________________________________________________________

________________________________________________________________

9. Does he/she currently have a problem with drugs?

0[ ]No

1[ ]Yes

9[ ]Unknown

10. Record age he/she began to have drug-related problems.

Ons Age

11. Record age he/she stopped using drugs heavily.

Rec Age

12. Interviewer judgement on reliability of this information:

1[ ]Good

2[ ]Fair

3[ ]Poor

FIGS: PSYCHOSIS CHECKLIST

Interview date:

- -

Month

Day

Year

Family last name:

Family ID number:

Informant name:

____________________ ____________________ ____________________
First MI Last

Informant ID:

Person being described name:

____________________ ____________________ ____________________
First MI Last

Person being described ID:

PSYCHOSIS

Code for a single episode (best recalled, worst episode if possible).

1. What were his/her unusual beliefs or experiences?

Specify: ________________________________________________________

________________________________________________________________

________________________________________________________________

Did he/she ever…

1.a) …believe people were following him/her, or that someone was trying to hurt or poison him/her?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.b) …believe someone was reading his/her mind?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.c) …believe he/she was under the control of some outside person or power or force?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.d) …believe his/her thoughts were broadcast, or that an outside force took away his/her thoughts or put thoughts into his/her head?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.e) …have any other strange or unusual beliefs?

0[ ]No

1[ ]Yes

9[ ]Unknown

If yes: Describe: ________________________________________________________________________________________________________________

1.f) …see things that were not really there?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.g) …hear voices or other sounds that were not real?

0[ ]No

1[ ]Yes

9[ ]Unknown

If yes: Describe: ________________________________________________________________________________________________________________

If no: Skip to Question 1.h.

1.g.1) (Code YES if: Voice with content having no relation to depression or elation, or voice keeping up running commentary on subject’s behavior or thoughts, or two or more voices conversing.)

0[ ]No

1[ ]Yes

9[ ]Unknown

1.h) …speak in a way that was difficult to make sense of?

0[ ]No

1[ ]Yes

9[ ]Unknown

If yes: Describe: ________________________________________________________________________________________________________________

1.i) …seem to be physically stuck in one position, or move around excitedly without any purpose?

0[ ]No

1[ ]Yes

9[ ]Unknown

1.j) …appear to have no emotions, or inappropriate emotions?

0[ ]No

1[ ]Yes

9[ ]Unknown

2. How long did the longest of these experiences last?

Weeks

INTERVIEWER: If less than one week, unless successfully treated, STOP HERE. Otherwise continue, if informant is knowledgeable about this person.

INTERVIEWER: If subject did NOT have any episode of Major Depression or Mania (by FIGS checklists from this informant), skip to Question 6.

3. When any (SX above) happened, did he/she also have the mood disturbance we discussed before, at the same time?

0[ ]No

1[ ]Yes

9[ ]Unknown

If no: Skip to Question 6.

INTERVIEWER: For the rest of this checklist, "illness duration" refers to total time of illness, including active and prodromal and/or residual symptoms and/or treatment (include time on medication).

4. (Probe and code YES if mania and/or depression lasted at least 30% of total duration of illness described above, or medication for it.)

0[ ]No

1[ ]Yes

9[ ]Unknown

5. (Probe and code YES if illness described above, or medication for it, was ever present for as long as one week, without depression and/or mania.)

0[ ]No

1[ ]Yes

9[ ]Unknown

If no: Skip to Question 6.

5.a) (Code YES if the above was true for as long as two weeks.)

0[ ]No

1[ ]Yes

9[ ]Unknown

6. Code and describe professional treatment (Code and describe all that apply):

0[ ]None

1[ ]Inpatient: ___________________________________________________

2[ ]Outpatient: __________________________________________________

3[ ]ECT: _____________________________________________________

4[ ]Medication: __________________________________________________

9[ ]Unknown

Describe details and/or other treatment: ___________________________________________________________________________________________

7.) Age of onset:

Age

8. Number of episodes (Code 001 if chronic symptoms and/or treatment since onset):

Episodes

9. Total illness duration (all episodes, includes active and prodromal and/or residual symptoms and/or treatment). OR

Weeks

Years

10. Rate and code impairment or incapacitation:

0[ ]None

1[ ]Impaired

2[ ]Incapacitated

9[ ]Unknown

11. Interviewer judgement on reliability of this information:

1[ ]Good

2[ ]Fair

3[ ]Poor

INTERVIEWER: If informant apparently does not know subject well enough to give information on Prodromal/Residual symptoms, STOP HERE.

If duration criterion for DSM III-R Schizophrenia, Chronic Type, already met, (Question 9, total illness duration > 2 years), STOP HERE

INTERVIEWER: Use this page only if Schizo-affective is ruled out (by Questions 3 to 5 above), or if the psychosis symptoms lasted at least one week (or shorter duration if successfully treated).

Establishing the Prodromal Period:

16. Now I would like to ask you about the year before his/her (psychotic symptoms) started. During that time did he/she…

16.a) …stay away from family and friends, become socially isolated?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.b) …have trouble doing his/her job, going to school, or doing work at home?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.c) …do something peculiar like talking to self in public?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.d) …neglect hygiene and grooming?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.e) …appear to have no emotions or inappropriate emotions?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.f) …speak in a way that was hard to understand, or was he/she at a loss for words?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.g) …have unusual beliefs or ideas?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.h) …have unusual perceptions, like sensing the presence of a person not actually present?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.i) …have no interests, no energy?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.j) …find special meaning in TV, radio, or newspaper articles?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.k) …feel nervous with other people?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.l) …worry that people were out to get him/her?

0[ ]No

1[ ]Yes

9[ ]Unknown

(Ask after completing question 16.a-n for the Prodromal period:)

Establishing the Residual Period:

16. Now I would like to ask you about the year after his/her (psychotic symptoms) stopped. During that time did he/she…

16.a) …stay away from family and friends, become socially isolated?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.b) …have trouble doing his/her job, going to school, or doing work at home?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.c) …do something peculiar like talking to self in public?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.d) …neglect hygiene and grooming?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.e) …appear to have no emotions or inappropriate emotions?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.f) …speak in a way that was hard to understand, or was he/she at a loss for words?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.g) …have unusual beliefs or ideas?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.h) …have unusual perceptions, like sensing the presence of a person not actually present?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.i) …have no interests, no energy?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.j) …find special meaning in TV, radio, or newspaper articles?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.k) …feel nervous with other people?

0[ ]No

1[ ]Yes

9[ ]Unknown

16.l) …worry that people were out to get him/her?

0[ ]No

1[ ]Yes

9[ ]Unknown

17.a). How long did he/she have these experiences?

Weeks

17.b). How long did he/she have these experiences after his/her (Active psychotic features) stopped?
Weeks

18. Was he/she always this way?

0[ ]No

1[ ]Yes

9[ ]Unknown



FIGS: PARANOID/SCHIZOID/SCHIZOTYPAL PERSONALITY CHECKLIST

SITE OPTIONAL

Interview date:

- -

Month

Day

Year

Family last name:

Family ID number:

Informant name:

____________________ ____________________ ____________________
First MI Last

Informant ID:

Person being described name:

____________________ ____________________ ____________________
First MI Last

Person being described ID:

PARANOID PERSONALITY

Code for a single episode (best recalled, worst episode if possible).

1. Does he/she…

1.a) …often keep an eye out to stop people from taking advantage of him/her?

Expects, without sufficient basis, to be exploited/harmed by others.

0[ ]No

1[ ]Yes

9[ ]Unknown

1.b) …get concerned that friends or co-workers are not really loyal or trustworthy?

Questions, without justification, loyalty of friends or associates.

0[ ]No

1[ ]Yes

9[ ]Unknown

1.c) …often pick up hidden threats or put-downs from what people say or do?

Reads hidden demeaning or threatening meanings into benign remarks or events.

0[ ]No

1[ ]Yes

9[ ]Unknown

1.d) …take a long time to forgive someone if they have insulted or hurt him/her? Bears grudges or unforgiving of insults/slights.

0[ ]No

1[ ]Yes

9[ ]Unknown

1.e) …seem to believe it is best not to let other people know much about him/her?

Reluctant to confide in others because of unwarranted fear that information will be used against him/her.

0[ ]No

1[ ]Yes

9[ ]Unknown

1.f) …often get angry about being insulted or slighted?

Easily slighted, quick to react with anger or counterattack.

0[ ]No

1[ ]Yes

9[ ]Unknown

1.g) …seem to be a jealous person?

Ever suspected that his/her spouse/partner was unfaithful? Questions, without justification, fidelity of spouse or sexual partner.

0[ ]No

1[ ]Yes

9[ ]Unknown

SCHIZOID PERSONALITY

2. Does he/she…

2.a) …seem not to want or enjoy close relationships, like with family or friends?

Neither desires nor enjoys close relationships, including family.

0[ ]No

1[ ]Yes

9[ ]Unknown

2.b) …prefer to do things alone rather than with other people?

Almost always chooses solitary activities.

0[ ]No

1[ ]Yes

9[ ]Unknown

2.c) hardly ever seem to have strong feelings, like being very angry or very happy?

Rarely, if ever, claims or appears to experience strong emotions, anger/joy.

0[ ]No

1[ ]Yes

9[ ]Unknown

2.d) seem uninterested in being sexually involved with another person?

Little if any desire to have sexual experiences with another person (age taken into account).

0[ ]No

1[ ]Yes

9[ ]Unknown

2.e) …seem not to care if people praise or criticize him/her?

Indifferent to praise and criticism from others.

0[ ]No

1[ ]Yes

9[ ]Unknown

2.f) …have no one to be really close to or confide in, or just one person, outside of the immediate family?

No close friends or confidants, or only one, other than first-degree relatives.

0[ ]No

1[ ]Yes

9[ ]Unknown

2.g) act cold or distant, hardly ever smile or nod back at people?

Constricted affect, aloof, cold, rarely reciprocates gestures or expressions.

0[ ]No

1[ ]Yes

9[ ]Unknown

SCHIZOTYPAL PERSONALITY

3. Does he/she…

3.a) …wonder if people talking to each other are talking about him/her? Say that a common event or object is a special sign for him/her?

Ideas of reference (not delusions of reference).

0[ ]No

1[ ]Yes

9[ ]Unknown

3.b) …often act nervous in a group of unfamiliar people?

Excessive social anxiety.

0[ ]No

1[ ]Yes

9[ ]Unknown

3.c) …reports experiences with the supernatural? Believe in astrology, seeing the future, UFOs, ESP or a "sixth sense"?

Odd beliefs or magical thinking, influencing behavior and inconsistent with subcultural norms.

0[ ]No

1[ ]Yes

9[ ]Unknown

3.d) …mistake objects or shadows for people, or noises for voices? Have a sense that some invisible person or force is around? See faces change before his/her eyes?

Unusual perceptual experiences.

0[ ]No

1[ ]Yes

9[ ]Unknown

3.e) …behave in odd or eccentric ways? Look peculiar or untidy, have unusual mannerisms, talk to him/herself?

Odd, eccentric, peculiar behavior or appearance.

0[ ]No

1[ ]Yes

9[ ]Unknown

3.f) …sometimes make it hard to follow what he/she is saying? Ramble off the subject, talk in vague or abstract terms?

Odd speech (without loosened associations or incoherence).

0[ ]No

1[ ]Yes

9[ ]Unknown

3.g) …sometimes act silly, not in keeping with the situation? Or tend not to show any feelings in response to people?

Inappropriate or constricted affect (e.g., silly or aloof).

0[ ]No

1[ ]Yes

9[ ]Unknown

INTERVIEWER: If any YES to any Personality Disorders, ask the following questions (to be used for research, not diagnosis).

IMPAIRMENT DISTRESS

4. Does he/she have problems because of this behavior or thinking or feeling-either with the family or socially, or at work or school?

Significant social or occupational impairment.

0[ ]No

1[ ]Yes

9[ ]Unknown

5. Does this behavior or thinking or feeling cause the person unhappiness?

Significant subjective distress.

0[ ]No

1[ ]Yes

9[ ]Unknown

6. Interviewer judgement on reliability of this information:

1[ ]Good

2[ ]Fair

3[ ]Poor

Protocol Name from Source:

Family Interview for Genetic Studies (FIGS)

Availability:

Publicly available

Personnel and Training Required

The interviewer must be trained to conduct personal psychiatric interviews with individuals from the general population. The interviewer must be trained and found to be competent (i.e., tested by an expert) at the completion of personal interviews. The interviewer should be trained to prompt respondents further if a "don’t know" response is provided.

Equipment Needs

The PhenX Working Group acknowledges these questions can be administered in a computerized or noncomputerized format (i.e., paper-and-pencil instrument). Computer software is necessary to develop computer-assisted instruments. The interviewer will require a laptop computer/handheld computer to administer a computer-assisted questionnaire.

Requirements
Requirement CategoryRequired
Major equipment No
Specialized training No
Specialized requirements for biospecimen collection No
Average time of greater than 15 minutes in an unaffected individual Yes
Mode of Administration

Interviewer-administered questionnaire

Life Stage:

Adult

Participants:

Adults, ages 18 years and older

Selection Rationale

The use of the Family Interview for Genetic Studies (FIGS) has advanced family studies for research in genetic psychiatry. The questionnaire is reliable and valid for gathering diagnostic information about relatives of a subject.

Language

English

Standards
StandardNameIDSource
Common Data Elements (CDE) Mental Health Disorder Family Medical History Assessment Score 5627332 CDE Browser
Human Phenotype Ontology Behavioral abnormality HP:0000708 HPO
Derived Variables

None

Process and Review

Not applicable.

Source

National Institute of Mental Health (NIMH), Center for Collaborative Genomics Research on Mental Disorders. (1999, February 11). Family Interview for Genetic Studies (FIGS). St. Louis. MO: Department of Psychiatry, Washington University School of Medicine. https://www.nimhgenetics.org/interviews/figs/

General References

Maxwell, M. E. (1992). Family Interview for Genetic Studies (FIGS): Manual For FIGS. Bethesda, MD: Clinical Neurogenetics Branch, Intramural Research Program, National Institute of Mental Health.

Protocol ID:

660701

Variables:
Export Variables
Variable Name Variable IDVariable DescriptiondbGaP Mapping
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Accidents
PX660701061200 Because of drinking, did he/she ever have more
problems such as accidental injuries? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Binges
PX660701061700 Because of drinking, did he/she ever have more
problems such as binges or benders more than once? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Blackouts
PX660701061600 Because of drinking, did he/she ever have more
problems such as blackouts more than once? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Control
PX660701060800 Because of drinking, did he/she ever have more
problems such as being unable to stop or cut down on drinking? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Hurt
PX660701061100 Because of drinking, did he/she ever have more
problems such as being high from drinking when he/she could get hurt? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Legal_Trouble
PX660701061500 Because of drinking, did he/she ever have more
problems such as legal problems more than once (DWIs, arrests)? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Objections
PX660701061400 Because of drinking, did he/she ever have more
problems such as objections from the family or friends, at work or school? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Onset
PX660701062300 Record age he/she began to have more
alcohol-related problems. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Physical_Health
PX660701061800 Because of drinking, did he/she ever have more
problems such as physical health problems (liver disease, pancreatitis)? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Priorities
PX660701061300 Because of drinking, did he/she ever have more
problems such as reducing or giving up important activities? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Problem
PX660701062200 Does he/she currently have a problem with alcohol? N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Psychological_Health
PX660701061900 Because of drinking, did he/she ever have more
problems such as emotional or psychological problems (uninterested, depressed, suspicious/paranoid, having strange ideas)? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Quit
PX660701062400 Record age he/she stopped drinking heavily. N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Responsibilities
PX660701061000 Because of drinking, did he/she ever have more
problems such as being unable to work, go to school, or take care of household responsibilities? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Time
PX660701060900 Because of drinking, did he/she ever have more
problems such as spending a lot of time drinking or being hung over? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Treatment
PX660701062101 Did he/she go to AA or have any kind of more
treatment? (Code and describe all that apply) show less
N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Treatment_AA
PX660701062104 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Treatment_Inpatient
PX660701062102 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Treatment_Medication
PX660701062105 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Treatment_Outpatient
PX660701062103 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_Alcoholism_Withdrawal
PX660701062000 Because of drinking, did he/she ever have more
problems such as withdrawal symptoms (shakes, seizures/convulsions, DTs)? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Appetite
PX660701040800 During depression, did he/she have a change more
in appetite or weight without trying to? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Blame
PX660701041500 During depression, did he/she feel guilty, more
worthless or blame himself/herself? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Concentration
PX660701041600 During depression, did he/she have trouble more
concentrating or making decisions? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Daily
PX660701040600 During depression, was he/she depressed most more
of the day, nearly every day, for as long as a week or more? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Delusion
PX660701041800 During depression, did he/she have visions, more
or hear voices, or have beliefs or behavior that seem strange or unusual, at the same time as (symptoms above)? (If YES, complete a Psychosis Checklist after this one.) show less
N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Energy
PX660701041400 During depression, did he/she have less more
energy or feel tired out? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Episodes
PX660701042100 What is the number of episodes? N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Episode_Duration
PX660701042200 What is the duration of longest episode in weeks? N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Hands
PX660701041300 During depression, did he/she pace or wring more
his/her hands? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Id
PX660701040300 What is the family ID number? N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Informant_Id
PX660701040500 What is the Informant's ID number? N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Informant_Name
PX660701040400 What is the first, middle, and last name of more
the Informant? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Interest
PX660701040700 During depression, did he/she lose interest more
in things or become unable to enjoy most things, for as long as a week? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Interviewer_Judgement
PX660701042400 Interviewer judgement on reliability of this more
information: show less
N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Interview_Date
PX660701040100 What's the interview date? N/A
PX660701_FamilyHistory_MentalDisorders_Depression_LastName
PX660701040200 What is the family last name? N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Onset
PX660701042000 What was the age of onset? N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Rate_Impairment
PX660701042300 Rate and code impairment or incapacitation: N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Responsibilities
PX660701041000 During depression, did he/she become unable more
to work, go to school, or take care of household responsibilities? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Responsibilities_Describe
PX660701041100 If Yes, describe N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Sleep
PX660701040900 During depression, did he/she have a change more
in sleep patterns (either too much or too little)? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Slower
PX660701041200 During depression, did he/she move or speak more
more slowly than usual? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Suicide
PX660701041700 During depression, did he/she talk of death more
or suicide? Or try suicide? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Treatment
PX660701041901 Code and describe professional treatment: N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Treatment_Ect
PX660701041904 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Treatment_Inpatient
PX660701041902 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Treatment_Medication
PX660701041905 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_Depression_Treatment_Outpatient
PX660701041903 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_DrugAbuse_Drugs
PX660701062500 Which drugs did he/she have trouble with? Specify N/A
PX660701_FamilyHistory_MentalDisorders_DrugAbuse_Legal_Trouble
PX660701062800 Because of his/her drug use, did he/she have more
legal problems (arrests for possessing, selling, or stealing drugs)? show less
N/A
PX660701_FamilyHistory_MentalDisorders_DrugAbuse_Physical_Health
PX660701062600 Because of his/her drug use, did he/she have more
physical health problems (hepatitis, overdose, withdrawal symptoms, accidental injuries)? show less
N/A
PX660701_FamilyHistory_MentalDisorders_DrugAbuse_Problem
PX660701063600 Does he/she currently have a problem with drugs? N/A
PX660701_FamilyHistory_MentalDisorders_DrugAbuse_Psychological_Health
PX660701062700 Because of his/her drug use, did he/she have more
emotional or psychological problems (uninterested, depressed, suspicious/paranoid, having strange ideas)? show less
N/A
PX660701_FamilyHistory_MentalDisorders_DrugAbuse_Quit
PX660701063700 Record age he/she stopped using drugs heavily. N/A
PX660701_FamilyHistory_MentalDisorders_DrugAbuse_Relationships
PX660701062900 Because of his/her drug use, did he/she have more
problems with family or friends? show less
N/A
PX660701_FamilyHistory_MentalDisorders_DrugAbuse_Responsibilities
PX660701063000 Because of his/her drug use, did he/she have more
troubles at work or school? show less
N/A
PX660701_FamilyHistory_MentalDisorders_DrugAbuse_Treatment
PX660701063100 Did he/she go to NA or have any kind of more
treatment? (Code and describe all that apply) show less
N/A
PX660701_FamilyHistory_MentalDisorders_DrugAbuse_Treatment_Inpatient
PX660701063200 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_DrugAbuse_Treatment_Medication
PX660701063500 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_DrugAbuse_Treatment_NA
PX660701063400 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_DrugAbuse_Treatment_Outpatient
PX660701063300 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_Figs_Cause_Death
PX660701011300 If deceased, cause of death N/A
PX660701_FamilyHistory_MentalDisorders_Figs_Id
PX660701010300 What is the family ID number? N/A
PX660701_FamilyHistory_MentalDisorders_Figs_Informant_Id
PX660701010500 What is the Informant's ID number? N/A
PX660701_FamilyHistory_MentalDisorders_Figs_Informant_Name
PX660701010400 What is the first, middle, and last name of more
the Informant? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Figs_Interview_Date
PX660701010100 What's the interview date? N/A
PX660701_FamilyHistory_MentalDisorders_Figs_LastKnown_Age
PX660701011100 Age when subject last seen or known about, or died N/A
PX660701_FamilyHistory_MentalDisorders_Figs_LastKnown_Date
PX660701011200 Year when subject last seen or known about, more
or died show less
N/A
PX660701_FamilyHistory_MentalDisorders_Figs_LastName
PX660701010200 What is the family last name? N/A
PX660701_FamilyHistory_MentalDisorders_Figs_Psychiatric_Problems
PX660701011400 Probe: has he/she had any psychiatric or more
personality problems like those we mentioned earlier? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Figs_Relationship
PX660701010800 What is the subject's relationship to the more
Informant? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Figs_Subject_Birthdate
PX660701010900 What is the birthdate of the person described? N/A
PX660701_FamilyHistory_MentalDisorders_Figs_Subject_Id
PX660701010700 What is the ID number of the person being more
described? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Figs_Subject_Living
PX660701011000 Is person described living? N/A
PX660701_FamilyHistory_MentalDisorders_Figs_Subject_Name
PX660701010600 What is the first, middle, and last name of more
the person being described? show less
N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Adopted
PX660701030600 Was anyone adopted? N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Behavior
PX660701032100 (Did anyone) seem odd or eccentric in more
behavior or appearance? show less
N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Delusion
PX660701032200 (Was anyone) extremely jealous, or more
suspicious, or believe in magic, or see special meanings in things that no one else saw? show less
N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Depression
PX660701031100 Feel very low for a couple of weeks or more, more
or have a diagnosis of depression? show less
N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Hospitalization
PX660701031800 (Was anyone) hospitalized for psychiatric more
problems, or for drug or alcohol problems? show less
N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Id
PX660701030300 What is the family ID number? N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Informant_Id
PX660701030500 What is the Informant's ID number? N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Informant_Name
PX660701030400 What is the first, middle, and last name of more
the Informant? show less
N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Inherited_Disease
PX660701031900 Have inherited medical diseases such as more
Huntington's disease or seizure disorder or any other disorders of the brain or nervous system? show less
N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Interview_Date
PX660701030100 What's the interview date? N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_LastName
PX660701030200 What is the family last name? N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Loner
PX660701032000 (Did anyone) have few friends, or seem to be more
a loner? show less
N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Mania
PX660701031300 Seem overexcited (or manic) day and night, more
or have a diagnosis of mania? show less
N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Mental_Retardation
PX660701030700 Was anyone mentally retarded? N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Nerves
PX660701030800 Have problems with their nerves or emotions? N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Nerves_Lithium
PX660701031000 Take lithium? N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Nerves_Medication
PX660701030900 Take medicine or see a doctor for it? N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Schizophrenia
PX660701031500 Have unusual or bizarre behavior, or have a more
diagnosis of schizophrenia? show less
N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Substance_Abuse
PX660701031700 Have alcohol or drug use that caused more
problems (with health, family, job, or police)? Go to AA or NA, or have treatment for this? show less
N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Suicide
PX660701031200 Attempt or complete suicide? N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Trouble
PX660701031600 Have trouble with the police, with more
completing school, or with keeping a job? show less
N/A
PX660701_FamilyHistory_MentalDisorders_GeneralScreening_Visions
PX660701031400 Have visions, hear voices, or have beliefs more
that seem strange or unreal? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Impairment_Distress
PX660701072700 Does this behavior or thinking or feeling more
cause the person unhappiness? Significant subjective distress. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Impairment_Interaction
PX660701072600 Does he/she have problems because of this more
behavior or thinking or feelingÔøΩeither with the family or socially, or at work or school? Significant social or occupational impairment. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Impairment_Interviewer_Judgement
PX660701072800 Interviewer judgement on reliability of this more
information: show less
N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Distracted
PX660701051600 For most of the time day and night over more
several days, did he/she (more than usual), become easily distracted? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Episodes
PX660701052100 What is the number of episodes? N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Episode_Duration
PX660701052200 What is the duration of longest episode in weeks? N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Excited
PX660701050700 For most of the time day and night over more
several days, did he/she (more than usual), become so excited or agitated it was impossible to converse with him/her? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Focus
PX660701051500 For most of the time day and night over more
several days, did he/she (more than usual), jump from one idea to another? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Happy
PX660701050600 For most of the time day and night over more
several days, did he/she (more than usual), seem too happy/high/excited? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Id
PX660701050300 What is the family ID number? N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Informant_Id
PX660701050500 What is the Informant's ID number? N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Informant_Name
PX660701050400 What is the first, middle, and last name of more
the Informant? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Interviewer_Judgement
PX660701052400 Interviewer judgement on reliability of this more
information: show less
N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Interview_Date
PX660701050100 What's the interview date? N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Irritable
PX660701050800 For most of the time day and night over more
several days, did he/she (more than usual), act very irritable or angry? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Judgement
PX660701051000 For most of the time day and night over more
several days, did he/she (more than usual), show poor judgement (e.g., spending sprees, sexual indiscretions?) show less
N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Judgement_Describe
PX660701051100 If Yes, describe N/A
PX660701_FamilyHistory_MentalDisorders_Mania_LastName
PX660701050200 What is the family last name? N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Obnoxious
PX660701051200 For most of the time day and night over more
several days, did he/she (more than usual), behave in such a way as to cause difficulty for those around him/her (obnoxious/manipulative)? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Occupied
PX660701051700 For most of the time day and night over more
several days, did he/she (more than usual), get involved in too many activities at work or school? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Onset
PX660701052000 What was the age of onset? N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Powers
PX660701051300 For most of the time day and night over more
several days, did he/she (more than usual), feel that he/she had special gifts or powers? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Rate_Impairment
PX660701052300 Rate and code impairment or incapacitation: N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Sleep
PX660701050900 For most of the time day and night over more
several days, did he/she (more than usual), need less sleep without feeling tired? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Talkative
PX660701051400 For most of the time day and night over more
several days, did he/she (more than usual), become more talkative than usual? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Treatment
PX660701051901 Code and describe professional treatment: N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Treatment_Ect
PX660701051904 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Treatment_Inpatient
PX660701051902 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Treatment_Medication
PX660701051905 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Treatment_Outpatient
PX660701051903 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_Mania_Visions
PX660701051800 For most of the time day and night over more
several days, did he/she (more than usual), have visions? hear voices? have beliefs or behavior that seem strange or unusual? at the same time as (above symptoms)? (If YES, complete a Psychosis Checklist after this one.) show less
N/A
PX660701_FamilyHistory_MentalDisorders_OtherDisorders_Disorders_Other
PX660701020100 Indicate any disorder not in the checklists more
and complete questions 1.aÔøΩf for the disorder. Specify: show less
N/A
PX660701_FamilyHistory_MentalDisorders_OtherDisorders_Episodes
PX660701020400 What is the number of episodes? N/A
PX660701_FamilyHistory_MentalDisorders_OtherDisorders_Episode_Duration
PX660701020500 What is the duration of longest episode in weeks? N/A
PX660701_FamilyHistory_MentalDisorders_OtherDisorders_Interviewer_Judgement
PX660701020700 Interviewer judgement on reliability of this more
information: show less
N/A
PX660701_FamilyHistory_MentalDisorders_OtherDisorders_Onset_Age
PX660701020300 What is the age of onset? N/A
PX660701_FamilyHistory_MentalDisorders_OtherDisorders_Rate_Impairment
PX660701020600 Rate and code impairment or incapacitation: N/A
PX660701_FamilyHistory_MentalDisorders_OtherDisorders_Treatment
PX660701020201 Code and describe professional treatment: N/A
PX660701_FamilyHistory_MentalDisorders_OtherDisorders_Treatment_Ect
PX660701020204 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_OtherDisorders_Treatment_Inpatient
PX660701020202 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_OtherDisorders_Treatment_Medication
PX660701020205 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_OtherDisorders_Treatment_Outpatient
PX660701020203 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_Paranoid_Anger
PX660701071000 Does he/she often get angry about being more
insulted or slighted? Easily slighted, quick to react with anger or counterattack. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Paranoid_Exploitation
PX660701070500 Does he/she often keep an eye out to stop more
people from taking advantage of him/her? Expects, without sufficient basis, to be exploited/harmed by others. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Paranoid_Grudges
PX660701070800 Does he/she take a long time to forgive more
someone if they have insulted or hurt him/her? Bears grudges or unforgiving of insults/slights. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Paranoid_Id
PX660701070200 What is the family ID number? N/A
PX660701_FamilyHistory_MentalDisorders_Paranoid_Informant_Id
PX660701070400 What is the Informant's ID number? N/A
PX660701_FamilyHistory_MentalDisorders_Paranoid_Informant_Name
PX660701070300 What is the first, middle, and last name of more
the Informant? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Paranoid_Interpretation
PX660701070700 Does he/she often pick up hidden threats or more
put-downs from what people say or do? Reads hidden demeaning or threatening meanings into benign remarks or events. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Paranoid_Interview_Date
PX660701070000 What's the interview date? N/A
PX660701_FamilyHistory_MentalDisorders_Paranoid_Jealousy
PX660701071100 Does he/she seem to be a jealous person? more
Ever suspected that his/her spouse/partner was unfaithful? Questions, without justification, fidelity of spouse or sexual partner. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Paranoid_LastName
PX660701070100 What is the family last name? N/A
PX660701_FamilyHistory_MentalDisorders_Paranoid_Loyalty
PX660701070600 Does he/she get concerned that friends or more
co-workers are not really loyal or trustworthy? Questions, without justification, loyalty of friends or associates. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Paranoid_Trust
PX660701070900 Does he/she seem to believe it is best not more
to let other people know much about him/her? Reluctant to confide in others because of unwarranted fear that information will be used against him/her. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Prodomal_Behavior
PX660701067500 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she do something peculiar like talking to self in public? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Prodomal_Beliefs
PX660701067900 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she have unusual beliefs or ideas? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Prodomal_Emotions
PX660701067700 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she appear to have no emotions or inappropriate emotions? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Prodomal_Energy
PX660701068100 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she have no interests, no energy? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Prodomal_Hygiene
PX660701067600 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she neglect hygiene and grooming? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Prodomal_Interpretation
PX660701068200 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she find special meaning in TV, radio, or newspaper articles? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Prodomal_Nervous
PX660701068300 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she feel nervous with other people? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Prodomal_Perceptions
PX660701068000 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she have unusual perceptions, like sensing the presence of a person not actually present? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Prodomal_Responsibilites
PX660701067400 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she have trouble doing his/her job, going to school, or doing work at home? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Prodomal_Social
PX660701067300 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she stay away from family and friends, become socially isolated? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Prodomal_Speech
PX660701067800 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she speak in a way that was hard to understand, or was he/she at a loss for words? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Prodomal_Worry
PX660701068400 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she worry that people were out to get him/her? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Beliefs
PX660701064600 Code for a single episode (best recalled, more
worst episode if possible). What were his/her unusual beliefs or experiences? Specify show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Broadcast_Thoughts
PX660701065000 Code for a single episode (best recalled, more
worst episode if possible). Did he/she ever believe his/her thoughts were broadcast, or that an outside force took away his/her thoughts or put thoughts into his/her head? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Duration
PX660701066300 (Probe and code YES if mania and/or more
depression lasted at least 30% of total duration of illness described above, or medication for it.) show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Duration_Weeks
PX660701067001 Total illness duration (all episodes, more
includes active and prodromal and/or residual symptoms and/or treatment). show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Duration_Years
PX660701067002 Total illness duration (all episodes, more
includes active and prodromal and/or residual symptoms and/or treatment). show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Emotions
PX660701066000 Code for a single episode (best recalled, more
worst episode if possible). Did he/she ever appear to have no emotions, or inappropriate emotions? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Episode
PX660701066100 How long did the longest of these more
experiences last? In weeks show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Episodes
PX660701066900 Number of episodes (Code 001 if chronic more
symptoms and/or treatment since onset): show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Hallucination_Audio
PX660701065400 Code for a single episode (best recalled, more
worst episode if possible). Did he/she ever hear voices or other sounds that were not real? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Hallucination_Describe
PX660701065500 If Yes, describe N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Hallucination_Other
PX660701065600 (Code YES if: Voice with content having no more
relation to depression or elation, or voice keeping up running commentary on subject's behavior or thoughts, or two or more voices conversing.) show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Hallucination_Sight
PX660701065300 Code for a single episode (best recalled, more
worst episode if possible). Did he/she ever see things that were not really there? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Harm
PX660701064700 Code for a single episode (best recalled, more
worst episode if possible). Did he/she ever believe people were following him/her, or that someone was trying to hurt or poison him/her? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Id
PX660701064100 What is the family ID number? N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Informant_Id
PX660701064300 What is the Informant's ID number? N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Informant_Name
PX660701064200 What is the first, middle, and last name of more
the Informant? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Interviewer_Judgement
PX660701067200 Interviewer judgement on reliability of this more
information: show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Interview_Date
PX660701063900 What's the interview date? N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_LastName
PX660701064000 What is the family last name? N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Medication
PX660701066400 (Probe and code YES if illness described more
above, or medication for it, was ever present for as long as one week, without depression and/or mania.) show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Mindreading
PX660701064800 Code for a single episode (best recalled, more
worst episode if possible). Did he/she ever believe someone was reading his/her mind? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Mood
PX660701066200 When any (SX above) happened, did he/she more
also have the mood disturbance we discussed before, at the same time? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Onset
PX660701066800 What is the subject's age of onset? N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_OtherBeliefs
PX660701065100 Code for a single episode (best recalled, more
worst episode if possible). Did he/she ever have any other strange or unusual beliefs? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_OtherBeliefs_Describe
PX660701065200 If Yes, describe N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_OtherDetails
PX660701066700 Describe details and/or other treatment: N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Outsidecontrol
PX660701064900 Code for a single episode (best recalled, more
worst episode if possible). Did he/she ever believe he/she was under the control of some outside person or power or force? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Physical
PX660701065900 Code for a single episode (best recalled, more
worst episode if possible). Did he/she ever seem to be physically stuck in one position, or move around excitedly without any purpose? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Rate_Impairment
PX660701067100 Rate and code impairment or incapacitation: N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Speech
PX660701065700 Code for a single episode (best recalled, more
worst episode if possible). Did he/she ever speak in a way that was difficult to make sense of? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Speech_Describe
PX660701065800 If Yes, describe N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Subject_Id
PX660701064500 What is the ID number of the person being more
described? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Subject_Name
PX660701064400 What is the first, middle, and last name of more
the person being described? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Treatment
PX660701066601 Code and describe professional treatment: N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Treatment_Ect
PX660701066604 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Treatment_Inpatient
PX660701066602 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Treatment_Medication
PX660701066605 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_Treatment_Outpatient
PX660701066603 Describe the treatment received. N/A
PX660701_FamilyHistory_MentalDisorders_Psychosis_TwoWeeks
PX660701066500 (Code YES if the above was true for as long more
as two weeks.) show less
N/A
PX660701_FamilyHistory_MentalDisorders_Residual_Behavior
PX660701068700 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she do something peculiar like talking to self in public? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Residual_Beliefs
PX660701069100 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she have unusual beliefs or ideas? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Residual_Emotions
PX660701068900 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she appear to have no emotions or inappropriate emotions? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Residual_Energy
PX660701069300 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she have no interests, no energy? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Residual_Episode
PX660701069700 How long did he/she have these experiences? N/A
PX660701_FamilyHistory_MentalDisorders_Residual_Episode_Other
PX660701069800 How long did he/she have these experiences more
after his/her (Active psychotic features) stopped? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Residual_History
PX660701069900 Was he/she always this way? N/A
PX660701_FamilyHistory_MentalDisorders_Residual_Hygiene
PX660701068800 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she neglect hygiene and grooming? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Residual_Interpretation
PX660701069400 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she find special meaning in TV, radio, or newspaper articles? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Residual_Nervous
PX660701069500 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she feel nervous with other people? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Residual_Perceptions
PX660701069200 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she have unusual perceptions, like sensing the presence of a person not actually present? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Residual_Responsibilites
PX660701068600 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she have trouble doing his/her job, going to school, or doing work at home? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Residual_Social
PX660701068500 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she stay away from family and friends, become socially isolated? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Residual_Speech
PX660701069000 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she speak in a way that was hard to understand, or was he/she at a loss for words? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Residual_Worry
PX660701069600 Now I would like to ask you about the year more
before his/her (psychotic symptoms) started. During that time did he/she worry that people were out to get him/her? show less
N/A
PX660701_FamilyHistory_MentalDisorders_Schizoid_Confide
PX660701071700 Does he/she have no one to be really close more
to or confide in, or just one person, outside of the immediate family? No close friends or confidants, or only one, other than first-degree relatives. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Schizoid_Emotions
PX660701071400 Does he/she hardly ever seem to have strong more
feelings, like being very angry or very happy? Rarely, if ever, claims or appears to experience strong emotions, anger/joy. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Schizoid_Interactions
PX660701071800 Does he/she act cold or distant, hardly ever more
smile or nod back at people? Constricted affect, aloof, cold, rarely reciprocates gestures or expressions. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Schizoid_Loner
PX660701071300 Does he/she prefer to do things alone rather more
than with other people? Almost always chooses solitary activities. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Schizoid_Praise
PX660701071600 Does he/she seem not to care if people more
praise or criticize him/her? Indifferent to praise and criticism from others. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Schizoid_Relationship
PX660701071200 Does he/she seem not to want or enjoy close more
relationships, like with family or friends? Neither desires nor enjoys close relationships, including family. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Schizoid_Sexuality
PX660701071500 Does he/she seem uninterested in being more
sexually involved with another person? Little if any desire to have sexual experiences with another person (age taken into account). show less
N/A
PX660701_FamilyHistory_MentalDisorders_Schizotypal_Behavior
PX660701072300 Does he/she behave in odd or eccentric ways? more
Look peculiar or untidy, have unusual mannerisms, talk to him/herself? Odd, eccentric, peculiar behavior or appearance. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Schizotypal_Composure
PX660701072500 Does he/she sometimes act silly, not in more
keeping with the situation? Or tend not to show any feelings in response to people? Inappropriate or constricted affect (e.g., silly or aloof). show less
N/A
PX660701_FamilyHistory_MentalDisorders_Schizotypal_Focus
PX660701072400 Does he/she sometimes make it hard to follow more
what he/she is saying? Ramble off the subject, talk in vague or abstract terms? Odd speech (without loosened associations or incoherence). show less
N/A
PX660701_FamilyHistory_MentalDisorders_Schizotypal_Nercous
PX660701072000 Does he/she often act nervous in a group of more
unfamiliar people? Excessive social anxiety. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Schizotypal_Paranoid
PX660701071900 Does he/she wonder if people talking to each more
other are talking about him/her? Say that a common event or object is a special sign for him/her? Ideas of reference (not delusions of reference). show less
N/A
PX660701_FamilyHistory_MentalDisorders_Schizotypal_Perception
PX660701072200 Does he/she mistake objects or shadows for more
people, or noises for voices? Have a sense that some invisible person or force is around? See faces change before his/her eyes? Unusual perceptual experiences. show less
N/A
PX660701_FamilyHistory_MentalDisorders_Schizotypal_Supernatural
PX660701072100 Does he/she reports experiences with the more
supernatural? Believe in astrology, seeing the future, UFOs, ESP or a 'sixth senseÔøΩ? Odd beliefs or magical thinking, influencing behavior and inconsistent with subcultural norms. show less
N/A
PX660701_FamilyHistory_MentalDisorders_SubstanceAbuse_Id
PX660701060300 What is the family ID number? N/A
PX660701_FamilyHistory_MentalDisorders_SubstanceAbuse_Informant_Id
PX660701060500 What is the Informant's ID number? N/A
PX660701_FamilyHistory_MentalDisorders_SubstanceAbuse_Informant_Name
PX660701060400 What is the first, middle, and last name of more
the Informant? show less
N/A
PX660701_FamilyHistory_MentalDisorders_SubstanceAbuse_Interviewer_Judgement
PX660701063800 Interviewer judgement on reliability of this more
information: show less
N/A
PX660701_FamilyHistory_MentalDisorders_SubstanceAbuse_Interview_Date
PX660701060100 What's the interview date? N/A
PX660701_FamilyHistory_MentalDisorders_SubstanceAbuse_LastName
PX660701060200 What is the family last name? N/A
PX660701_FamilyHistory_MentalDisorders_SubstanceAbuse_Subject_Id
PX660701060700 What is the ID number of the person being more
described? show less
N/A
PX660701_FamilyHistory_MentalDisorders_SubstanceAbuse_Subject_Name
PX660701060600 What is the first, middle, and last name of more
the person being described? show less
N/A
Mental Health Research
Measure Name:

Family History of Mental Illness

Release Date:

January 17, 2017

Definition

An interview to collect family psychiatric information of a person with a mental illness.

Purpose

This measure can be used to characterize the diagnoses in first- and second-degree biological relatives of a person with a major mental illness. Family history in close relatives allows an assessment of genetic susceptibility and may be seen as a psychosocial measure of family burden of illness.

Keywords

Early psychosis, family history, relatives, pedigree, symptom checklist, extended family, bilineal, extender, pointer, depression, mania, alcohol/drug abuse, psychosis, paranoid/schizoid/schizotypal personality, schizophrenia, bipolar, Family Interview for Genetic Studies, FIGS, National Institute of Mental Health, NIMH