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Early Psychosis Translational Research

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Auditory Continuous Performance Test (ACPT) Battery
#660401

Modified AX-Continuous Performance Test (AX-CPT)
#660201

Ragland, J.D., et al. Functional and neuroanatomic specificity of episodic memory dysfunction in schizophrenia: A functional magnetic resonance imaging study of the relational and item-specific encoding task. JAMA Psychiatry, 2015
#662601

National Health and Nutrition Examination Survey (NHANES), C-Reactive Protein (CRP), 2009-2010
#660601

Computerized Neurocognitive Battery (CNB)
#660101

National Institute of Mental Health (NIMH), Family Interview for Genetic Studies (FIGS), 1999
#660701

Family Interview for Genetic Studies (FIGS) - Abbreviated Version
#660702

Modified Cannon-Spoor Premorbid Adjustment Scale (PAS)
#660801

Relational and Item-Specific Encoding Task (RiSE)
#660301

Three-Dimensional (3D) Magnetization-Prepared RApid Gradient Echo (MP-RAGE)
#660501
Scope of Collection
Element Considered Final Measures in Toolkit
Family History of Mental Illness Family History of Mental Illness
Adverse Life Events
Premorbid Functioning Premorbid Adjustment in Psychosis
Medical History
Psychiatric Treatment History (including medication history, previous psychosocial interventions, inpatient treatment episodes, emergency department visits and antipsychotic medications at time of enrollments)
Prodromal Psychosis Symptoms
Age of First Prodromal Symptoms
Age of First Psychotic-Level Symptoms
Duration of Untreated Psychosis
Positive Syndrome Symptoms Clinician-Administered Psychiatric Assessment
Global Psychopathology Rating Scale
Current Physical Health (including medication side effects, smoking and cardio-metabolic risk factors) Physical Activity
Antipsychotic Medication Adherence
Antipsychotic Medication Extrapyramidal Side Effects
Multi-dimensional Assessment of Antipsychotic Medication Side Effects
Social and Role Functioning Social and Role Dysfunction in Psychosis and Schizophrenia
Arrests or Incarceration Incarceration
Family Burden Family Burden of Mental Illness
Family Expressed Emotion Toward Relatives with Psychosis and Schizophrenia
Family Functioning
Outpatient Treatments Mental Health Services Satisfaction
Hospitalizations for Psychiatric and Medical Illness (number, duration)
Emergency Department Visits, Crisis Intervention Services
Well-being/Mental Health Recovery Personal Well Being
Quality of Life
Hiring, Training and retention of Coordinated Specialty Care (CSC) staff
Availability of Required CSC Treatment Components
Fidelity Measures Related to Team-based CSC Treatment Model
Quality Measures Related to Provision of CSC Services
Outcome Measures Related to Symptoms, Functioning and Physical Health
CSC Clinic Caseload Size
Measures Related to Initial Engagement (e.g., Client, Family Member, Participation)
Measures Related to Participant Retention/Drop out
Measures of Client and Family Member Satisfaction Mental Health Services Satisfaction
Perception of Recovery Orientation and Care Quality of Mental Health Services
Psychosis Recovery Assessment
Shared Decision Making in Clinical Encounters
Neurocognitive Assessments Auditory Vigilance
Relational Encoding and Retrieval
Context Processing
Global Cognitive Functioning
Electrophysiological Assessments (e.g., ERP)
Eye-Tracking (pre- and Anti-saccade tasks)
Biomarkers and Behavioral Indicators that Predict to Trajectory of Illness C-Reactive Protein in Serum
Functional Brain Imaging Measures Brain Connectivity and Activation
Structural Brain Imaging Measures Brain Anatomical Imaging
Risk and Protective Factors that Span Modalities and Levels of Analysis (e.g., genetic, Brain, Neurobiological, Environmental and Behavioral) and Predict Movement along the illness Trajectory. (Source NIMH Strategic Plan)
Family History of Mental Illness Family History of Mental Illness
Adverse life Events
Premorbid Functioning Premorbid Adjustment in Psychosis
Medical History
Psychiatric Treatment History (including medication history, previous psychosocial interventions, inpatient treatment episodes, emergency department visits and antipsychotic medications at time of enrollments)
Prodromal Psychosis Symptoms
Age of First Prodromal Symptoms
Age of First Psychotic-Level Symptoms
Duration of Untreated Psychosis
Positive Syndrome Symptoms Clinician-Administered Psychiatric Assessment
Global Psychopathology Rating Scale
Current Physical Health (including medication side effects, smoking and cardio-metabolic risk factors) Physical Activity
Antipsychotic Medication Adherence
Antipsychotic Medication Extrapyramidal Side Effects
Multi-dimensional Assessment of Antipsychotic Medication Side Effects
Social and Role Functioning Social and Role Dysfunction in Psychosis and Schizophrenia
Arrests or Incarceration Incarceration
Family Burden Family Burden of Mental Illness
Family Expressed Emotion Toward Relatives with Psychosis and Schizophrenia
Family Functioning
Outpatient Treatments Mental Health Services Satisfaction
Hospitalizations for Psychiatric and Medical Illness (number, duration)
Emergency Department Visits, Crisis Intervention Services
Well-being/Mental Health Recovery Personal Well Being
Quality of Life
Hiring, Training and retention of Coordinated Specialty Care (CSC) staff
Availability of Required CSC Treatment Components
Fidelity Measures Related to Team-based CSC Treatment Model
Quality Measures Related to Provision of CSC Services
Outcome Measures Related to Symptoms, Functioning and Physical Health
CSC Clinic Caseload Size
Measures Related to Initial Engagement (e.g., Client, Family Member, Participation)
Measures Related to Participant Retention/Drop out
Measures of Client and Family Member Satisfaction Mental Health Services Satisfaction
Perception of Recovery Orientation and Care Quality of Mental Health Services
Psychosis Recovery Assessment
Shared Decision Making in Clinical Encounters
Neurocognitive Assessments Auditory Vigilance
Relational Encoding and Retrieval
Context Processing
Global Cognitive Functioning
Electrophysiological Assessments (e.g., ERP)
Eye-Tracking (pre- and Anti-saccade tasks)
Biomarkers and Behavioral Indicators that Predict to Trajectory of Illness C-Reactive Protein in Serum
Functional Brain Imaging Measures Brain Connectivity and Activation
Structural Brain Imaging Measures Brain Anatomical Imaging
Risk and Protective Factors that Span Modalities and Levels of Analysis (e.g., genetic, Brain, Neurobiological, Environmental and Behavioral) and Predict Movement along the illness Trajectory. (Source NIMH Strategic Plan)
Working Group Roster:

Clinical Services Panel:

Lisa Dixon, MD, MPH (Co-Chair)
Columbia University Medical Center
New York, NY
Diana Perkins, MD, MPH
University of North Carolina School of Medicine
Chapel Hill, NC
Nev Jones, PhD
Felton Institute
San Francisco, CA
Rachel Loewy, PhD
University of San Francisco School of Medicine
San Francisco, CA
Tamara Sale, MA
Portland State University
Portland, OR

Translational Research Panel:

Dost Öngür, MD, PhD (Co-Chair)
McLean Hospital
Belmont, MA
Cameron S. Carter, MD
University of California, Davis
Sacramento, CA
Raquel Gur, MD, PhD
University of Pennsylvania Perelman School of Medicine
Philadelphia, PA
Akira Sawa, MD, PhD
Johns Hopkins Hospital
Baltimore, MD
Larry J. Seidman, PhD
Harvard Medical School
Boston, MA
Carol Tamminga, MD
University of Texas Southwestern Medical School
Dallas, TX

Mental Health Research Panel Liaison, WG Manager and WG Supervisor:

Violet Devairakkam, WG Manager
RTI International
Rockville, MD
Marcie Rathbun, BS, WG Manager
RTI International
Research Triangle Park, NC
Rebecca Boyles, MS, WG Supervisor
RTI International
Research Triangle Park, NC
Wayne Huggins, PhD, WG Supervisor
RTI International
Research Triangle Park, NC

National Institute of Mental Health Liaison:

Gregory K. Farber, PhD
National Institute of Mental Health (NIMH)
Office of Technology Development and Coordination (Director)
Bethesda, MD
Robert K. Heinssen, PhD
National Institute of Mental Health (NIMH)
Division of Services and Intervention Research (Director)
Bethesda, MD

Substance Abuse and Mental Health Services (SAMHSA) Liaison:

Paolo del Vecchio, MSW
Substance Abuse and Mental Health Services Administration (SAMHSA)
Center for Mental Health Services (Director)
Rockville, MD

National Human Genome Research Institute (NHGRI) Liaison:

Margaret Ginoza
National Human Genome Research Institute (NHGRI)
Scientific Program Analyst
Bethesda, MD
Brenda Iglesias, BA
National Human Genome Research Institute (NHGRI)
Scientific Program Analyst
Bethesda, MD
Erin M. Ramos, PhD, MPH
National Human Genome Research Institute (NHGRI)
Bethesda, MD

Supplemental Information includes protocols that the Working Group or Expert Review Panel considered useful and highly relevant to the domain but do not meet the criteria for inclusion in the Toolkit.

Early Psychosis Collection Supplemental Information includes:
Additional Information:

There is no additional information for this collection.