Protocol - Frailty

Description:

The SOF Frailty Index is an assessment of frailty based on an individual's weight change over the past three years, physical ability to perform five chair stands without using arms for support, and energy level. If the individual meets two of the three criteria (weight loss of 5% or more, inability to do chair stands, low/lack of energy), the individual is considered frail.

Protocol:

Weight loss

What was your weight 3 years ago? __ __ __ lbs
What is your weight today? __ __ __ lbs
[Interviewer/computer: calculate weight loss percentage] Change in weight (Q1-Q2)/weight 3 years ago (Q1)

= ___ __ % loss

Ability to do 5 chair stands

4. [Interviewer: Ask respondent to sit in chair, then rise up without using arms, repeat 4 more times.] Was respondent able to do chair stands without assistance? Yes or No

Energy level

5. Do you feel full of energy? Yes or No

Scoring

Q1. Score = 1 if weight loss ? 5%, otherwise, score = 0

Q2. Score = 1 if unable to do chair stands without assistance (No), otherwise, score = 0

Q3. Score = 1, if No, otherwise, score = 0

If summed score is 2 or 3, respondent is frail;

if score is 1 respondent is pre-frail;

if score is 0, respondent is robust.

Protocol Name from Source:

Study of Osteoporotic Fractures (SOF) Frailty Index

Availability:

Publicly available

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Personnel and Training Required

The interviewer must be trained to conduct personal interviews with individuals from the general population. The interviewer must be trained and found to be competent (i.e., tested by an expert) at the completion of personal interviews. The interviewer should be trained to prompt respondents further if a "don't know" response is provided.

Equipment Needs

The PhenX Working Group acknowledges that these questions can be administered in a computerized or noncomputerized format (i.e., paper-and-pencil instrument). Computer software is necessary to develop computer-assisted instruments. The interviewer will require a laptop computer/handheld computer to administer a computer-assisted questionnaire. Chair for chair stands

Requirements

Requirement Category	Required

Mode of Administration

Interviewer-administered questionnaire

Life Stage:

Participants:

69 years of age and older

Specific Instructions:

Selection Rationale

This well-established protocol has been used on a large prospective cohort study of older adults.

Language

Standards

Standard	Name	ID	Source
Common Data Elements (CDE)	Osteoporosis Study of Osteoporotic Fractures Frailty Index Assessment Score	6360511	CDE Browser

Process and Review

The Expert Review Panel has yet to review this measure.

Source

National Institute on Aging, Study of Osteoporotic Fractures (SOF) Frailty Index

General References

Protocol ID:

251001

Variables:

Export Variables

Variable Name	Variable ID	Variable Description	Version	dbGaP Mapping

Research Domain Information

Measure Name:

Frailty

Release Date:

N/A

Definition

Declines in physiologic complexity or reserve in body systems, leading to loss of homeostatic capability to withstand stressors and resulting vulnerabilities.

Purpose

Frailty is associated with weakness and the inability to perform normal daily activities, particularly in older adults. Frailty leads to increased morbidity and mortality.

Keywords

Activities of Daily Living, ADLs, Frailty Index, Study of Osteoporotic Fractures (SOF), weakness, geriatrics, falls, National Institute on Aging, NIA, gerontology, aging