Protocol - Relational and Item-Specific Encoding Task (RiSE)
The Relational and Item-Specific Encoding Task (RiSE) is a computerized test, developed in Eprime by the Cognitive Neuroscience Test Reliability and Clinical applications for Schizophrenia (CNTRACS) consortium, which evaluates item-specific encoding and relational encoding. The subject views visual objects (pictures) and responds yes/no to whether the objects are "living" (item-specific encoding). The subject then views pairs of visual objects and responds yes/no to whether or not one item can fit into the other (relational encoding). Then the subject views visual objects and indicates whether each object was "old" or "new," responding by way of confidence level high, medium, or low (item recognition). Lastly, the subject views pairs of visual objects and responds yes/no to whether or not the pairs were presented together in the relational encoding test (associative recognition).
There are three test forms available, each with different visual objects (pictures). The tests are in English; however, since the task uses pictures instead of words, the subject does not have to speak English to perform the task.
There are a total of four neurocognitive assessments: the Computerized Neurocognitive Battery (CNB) measures Global Cognitive Functioning, the AX-Continuous Performance Test (AX-CPT) measures Context Processing, the Relational and Item-Specific Encoding task (RiSE) measures Relational Encoding and Retrieval, and the Auditory Continuous Performance Test (ACPT) battery measures Auditory Vigilance.
RiSE and AX-CPT can be run together and can be downloaded together.
RiSE can be combined with Task functional magnetic resonance imaging (fMRI) as described by Ragland et al. (2015) to assist in identifying specific neural circuits.
Tasks can be downloaded for free from the CNTRACS website once a Request form has been completed and submitted. Link to the Request form can be found here:
Copies of the tasks, written in Eprime, can be downloaded off of the CNTRACS website at the link below:
Personnel and Training Required
The interviewer must be trained to conduct personal interviews with individuals from the general population. The interviewer must be trained and found to be competent (i.e., tested by an expert) at the completion of personal interviews. The interviewer should be trained to prompt respondents further if a "don’t know" response is provided. Training by an experienced group in administering and analyzing the results is recommended.
The PhenX Working Group acknowledges these questions are administered in a computerized format. The interviewer will require a laptop computer/handheld computer to administer this protocol. Eprime computer software is necessary to conduct this protocol.
|Specialized requirements for biospecimen collection||No|
|Average time of greater than 15 minutes in an unaffected individual||Yes|
Mode of Administration
Adolescent, Adult, Senior
Individuals 12 and older
The Cognitive Neuroscience Test Reliability and Clinical applications for Schizophrenia (CNTRACS) tasks have been used for many years. The tasks have been well studied in CNTRACS and have good test/re-test reliability. The tasks are very easy to use and have standardized instructions and a high level of subject acceptability. CNTRACS contains psychology resources that can be used by individuals who are not psychologists.
|caDSR Common Data Elements (CDE)||Cognitive Function Relational and Item-Specific Encoding Task Assessment Score||5626759||CDE Browser|
|caDSR Common Data Elements (CDE)||Cognitive Function Relational and Item-Specific Encoding Task Assessment Score||2018321||CDE Browser|
|Human Phenotype Ontology||Memory impairment||HP:0002354||HPO|
Process and Review
Protocol Name from Source
Relational and Item-Specific Encoding Task (RiSE)
Ragland, J. D., Ranganath, C., Barch, D. M., Gold, J. M., Haley, B., MacDonald, A. W., III, Silverstein, S. M., Strauss, M. E., Yonelinas, A. P., & Carter, C. S. (2012). Relational and Item-Specific Encoding (RISE): Task Development and psychometric characteristics. Schizophrenia Bulletin, 38(1), 114-124. doi:10.1093/schbul/sbr146
Gold, J. M., Barch, D. M., Carter, C. S., Dakin, S., Luck, S. J., MacDonald, A. W., III, Ragland, J. D., Ranganath, C., Kovacs, I., Silverstein, S. M., & Strauss, M. (2012). Clinical, functional, and intertask correlations of measures developed by the Cognitive Neuroscience Test Reliability and Clinical Applications for Schizophrenia Consortium. Schizophrenia Bulletin, 38(1), 144-152. doi:10.1093/schbul/sbr142
Ragland, J. D., Ranganath, C., Harms, M. P., Barch, D. M., Gold, J. M., Layher, E., Lesh, T., MacDonald, A. W., III, Niendam, T. A., Phillips, J., Silverstein, S. M., Yonelinas, A. P., & Carter, C. S. (2015). Multi-site fMRI study of the Relational and Item-Specific Encoding (RiSE) memory task: Imaging biomarker validation and specificity of frontal and hippocampal deficits in schizophrenia. JAMA Psychiatry, 72(9), 909-916. doi:10.1001/jamapsychiatry.2015.0276
Sheffield, J. M., Gold, J. M., Strauss, M. E., Carter, C. S., MacDonald, A. W., III, Ragland, J. D., Silverstein, S. M., & Barch, D. M. (2014). Common and specific cognitive deficits in schizophrenia: Relationships to function. Cognitive, Affective & Behavioral Neuroscience, 14(1), 161-174. doi:10.3758/s13415-013-0211-5
Strauss, M. E., McLouth, C. J., Barch, D. M., Carter, C. S., Gold, J. M., Luck, S. J., MacDonald, A. W., III, Ragland, J. D., Ranganath, C., Keane, B. P., & Silverstein S. M. (2014). Temporal stability and moderating effects of age and sex on CNTRaCS task performance. Schizophrenia Bulletin, 40(4), 835-844. doi:10.1093/schbul/sbt089
|Variable Name||Variable ID||Variable Description||dbGaP Mapping|
|PX660301000000||Protocol 660301 - proprietary. Check DCW for more||N/A|
Relational Encoding and Retrieval
January 17, 2017
Computer-administered task that measures cognitive functions.
This measure assesses deficits in cognition, specifically working memory and long-term memory.
Cognitive Neuroscience Test Reliability and Clinical applications for Schizophrenia, CNTRACS, Relational and Item-Specific Encoding Task, RiSE, retrieval, early psychosis, psychometrics, episodic memory