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Protocol - Acute Subjective Response to Substances - Current - Specific - Drugs

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Description:

The Addiction Research Center Inventory (ARCI) is a subjective drug effects questionnaire to evaluate whether a respondent is currently affected by or under the influence of a psychologically active drug. The self-reported questionnaire was developed in the early 1960s at the National Institute of Mental Health Addiction Research Center from the use of sentence completion and other association techniques on male subjects under drug and placebo conditions. The full form of ARCI contains 550 true-false items to delineate schizoid and psychopathic characteristics, and shortened versions are widely used for both males and females.

Protocol:

Amphetamine Scale:

1. I feel as if I would be more popular with people right now.

[ ] T

[ ] F

2. I feel a very pleasant emptiness.

[ ] T

[ ] F

3. My thoughts come more easily than usual.

[ ] T

[ ] F

4. I feel less discouraged than usual.

[ ] T

[ ] F

5. I feel more excited than dreamy.

[ ] T

[ ] F

6. Answering these questions is very easy right now.

[ ] T

[ ] F

7. My memory seems sharper to me than usual.

[ ] T

[ ] F

8. I feel as if I could write for hours.

[ ] T

[ ] F

9. I feel very patient.

[ ] T

[ ] F

10. Some parts of my body are tingling.

[ ] T

[ ] F

11. I have a weird feeling.

[ ] T

[ ] F

Morphine-Benzedrine Scale:

12. I feel as though I say things in the easiest possible way right now.

[ ] T

[ ] F

13. Things around me seem more pleasing than usual.

[ ] T

[ ] F

14. I have a pleasant feeling in my stomach.

[ ] T

[ ] F

15. I fear I will lose the contentment that I have now.

[ ] T

[ ] F

16. I feel in complete harmony with the world and those around me.

[ ] T

[ ] F

17. I can completely appreciate what others are saying when I am in this mood.

[ ] T

[ ] F

18. I would be happy all the time if I felt as good as I feel now.

[ ] T

[ ] F

19. I feel so good that I know other people can tell it.

[ ] T

[ ] F

20. I feel as if something pleasant had just happened to me.

[ ] T

[ ] F

21. I would be happy all the time if I felt as I do now.

[ ] T

[ ] F

22. I feel more clear headed than dreamy.

[ ] T

[ ] F

23. I feel as if I would be more popular with people right now.

[ ] T

[ ] F

24. I am in the mood to talk about the feelings I have.

[ ] T

[ ] F

25. I feel a very pleasant emptiness.

[ ] T

[ ] F

26. My thoughts come more easily than usual.

[ ] T

[ ] F

27. I feel less discouraged than usual.

[ ] T

[ ] F

Lysergic Acid Diethylamide (LSD) Scale:

28. I feel drowsy.

[ ] T

[ ] F

29. I would be happy all the time if I felt as I do now.

[ ] T

[ ] F

30. I feel very patient.

[ ] T

[ ] F

31. Some parts of my body are tingling.

[ ] T

[ ] F

32. I have a weird feeling.

[ ] T

[ ] F

33. It seems I am spending longer than I should on each of these questions.

[ ] T

[ ] F

34. My hands feel clumsy.

[ ] T

[ ] F

35. I notice my hand shakes when I write.

[ ] T

[ ] F

36. I have a disturbance in my stomach.

[ ] T

[ ] F

37. I have an increasing awareness of my bodily sensations.

[ ] T

[ ] F

38. I feel anxious and upset.

[ ] T

[ ] F

39. I have an unusual weakness in my muscles.

[ ] T

[ ] F

40. A thrill has gone through me one or more times since I started this test.

[ ] T

[ ] F

41. My movements are free, relaxed, and pleasurable.

[ ] T

[ ] F

Benzedrine Scale:

42. People might say I am a little dull right now.

[ ] T

[ ] F

43. I feel more clear headed than dreamy.

[ ] T

[ ] F

44. My thoughts come more easily than usual.

[ ] T

[ ] F

45. I am in the mood to talk about the feelings I have.

[ ] T

[ ] F

46. Answering these questions is very easy right now.

[ ] T

[ ] F

47. My memory seems sharper to me than usual.

[ ] T

[ ] F

48. I feel as if I could write for hours.

[ ] T

[ ] F

49. Some parts of my body are tingling.

[ ] T

[ ] F

50. My movements seem faster than usual.

[ ] T

[ ] F

51. I have better control over myself than usual.

[ ] T

[ ] F

52. My movements seem slower than usual.

[ ] T

[ ] F

53. I find it hard to keep my mind on a task or job.

[ ] T

[ ] F

54. I don’t feel like reading anything right now.

[ ] T

[ ] F

Pentobarbital-Chlorpromazine-Alcohol Scale:

55. My speech is slurred.

[ ] T

[ ] F

56. I am not as active as usual.

[ ] T

[ ] F

57. I have a feeling of just dragging along rather than coasting.

[ ] T

[ ] F

58. I feel sluggish.

[ ] T

[ ] F

59. My head feels heavy.

[ ] T

[ ] F

60. I feel like avoiding people although I usually do not feel this way.

[ ] T

[ ] F

61. I feel dizzy.

[ ] T

[ ] F

62. It seems harder than usual to move around.

[ ] T

[ ] F

63. I am moody.

[ ] T

[ ] F

64. People might say I am a little dull right now.

[ ] T

[ ] F

65. I feel drowsy.

[ ] T

[ ] F

66. I am full of energy.

[ ] T

[ ] F

67. I feel more clear headed than dreamy.

[ ] T

[ ] F

68. I feel more excited than dreamy.

[ ] T

[ ] F

69. A thrill has gone through me one or more times since I started this test.

[ ] T

[ ] F

Marijuana Scale:

70. Things around me seem more pleasing than usual.

[ ] T

[ ] F

71. I feel as if something pleasant had just happened to me.

[ ] T

[ ] F

72. I have difficulty in remembering.

[ ] T

[ ] F

73. I feel a very pleasant emptiness.

[ ] T

[ ] F

74. My mouth seems very dry.

[ ] T

[ ] F

75. Some parts of my body are tingling.

[ ] T

[ ] F

76. I have a weird feeling.

[ ] T

[ ] F

77. My movements seem slower than usual.

[ ] T

[ ] F

78. I notice that my heart is beating faster.

[ ] T

[ ] F

79. My thoughts seem to come and go.

[ ] T

[ ] F

80. I notice my hands are shaking.

[ ] T

[ ] F

81. I have an increasing awareness of my bodily sensations.

[ ] T

[ ] F

Scoring Procedures and Interpretation

The Addiction Research Center Inventory (ARCI) answer sheet is in true-false format. In scoring all scales, one point is given for each response, which agrees with the scoring direction (Haertzen, 1974a). One point is given for each true response in items 1-21, 23-27, 31-40, 43-51, 55-65, and 70-81. One point is given for each false response in the reverse-scored items 22, 28-30, 41, 42, 52-54, and 66-69. The final score for each scale is the sum of the total true and reverse-scored false responses.

Protocol Name from Source:

Addiction Research Center Inventory (ARCI)

Availability:

Publicly available

Personnel and Training Required

None

Equipment Needs

None

Requirements
Requirement CategoryRequired
Major equipment No
Specialized training No
Specialized requirements for biospecimen collection No
Average time of greater than 15 minutes in an unaffected individual No
Mode of Administration

Self-administered questionnaire

Life Stage:

Adult, Senior

Participants:

Adults aged 18 years and older

Specific Instructions:

The Addiction Research Center Inventory (ARCI) is used in laboratory studies to assess the subjective effects of acute doses of drugs of abuse, usually under double-blind, placebo-controlled conditions. The experimenter administers a single dose of a drug or a placebo using an appropriate route (oral, intravenous, intranasal, buccal, inhaled or other). The participant typically completes the ARCI before and again at regular intervals after ingesting active drug or placebo, to characterize the full time course of the drug effect, including the time of onset, time to peak, and return to baseline. The ARCI provides an index of similarity to different classes of drugs (e.g., stimulant, sedative, lysergic acid diethylamide [LSD]-like) and also provides a measure of euphoria induced by several different drugs. The LSD scale is used occasionally as an indicator of dysphoria (negative mood or confusion).

Depending on the purpose of the study, the investigator may include some but not all of these subscales. Note that some items appear on more than one scale. When using multiple scales, as demonstrated by Martin et al. (1971), each item should appear only once but should be scored in all appropriate scales, and the items (some of which are reverse-scored) should be intermixed across scales.

The Substance Abuse and Addiction Working Group acknowledges that the following questions may gather sensitive information relating to the use of substances and/or illegal conduct. If the information is released, it might be damaging to an individual’s employability, lead to social stigmatization, or lead to other consequences.

Most researchers assure confidentiality as part of their informed consent process, as required by their institutional review boards. Further assurance of confidentiality may be obtained by applying to the National Institutes of Health (NIH) for a Certificate of Confidentiality, which helps researchers protect the privacy of human research participants. The procedures for the Certificate of Confidentiality can be found at the Grants Policy website of NIH: http://grants1.nih.gov/grants/policy/coc/index.htm.

Selection Rationale

The full form of the Addiction Research Center Inventory (ARCI) effectively differentiates various subjective effects of drugs and detects similarities and differences of naturally occurring and experimentally induced behavioral abnormalities. However, it is rarely administered in its full form because of its length. An abbreviated form of the ARCI can be administered quickly and provides a good index of the quality, magnitude, and time course of a drug’s effects. A 49-item version is composed of five different scales (Amphetamine, Morphine-Benzedrine, Lysergic Acid Diethylamide (LSD), Benzedrine, and Pentobarbital-Chlorpromazine-Alcohol) for various classes of drug effects (Martin et al., 1971). A 53-item version also includes a sixth scale, measuring marijuana effects (Chait et al., 1994). This was selected due to its low burden.

Language

English, French, German, Spanish, Swedish

Standards
StandardNameIDSource
Common Data Elements (CDE) Addiction Research Center Inventory (ARCI) Assessment Description Text 3332435 CDE Browser
Derived Variables

None

Process and Review

The Expert Review Panel #3 (ERP 3) reviewed the measures in Alcohol, Tobacco and Other Substances, and Substance Abuse and Addiction domains.

Guidance from ERP 3 includes:

• No significant changes to measure

Back-compatible: NA no changes to Data Dictionary

Source

Amphetamine, Morphine-Benzedrine, Lysergic Acid (LSD), Benzedrine, and Pentobarbital-Chlorpromazine-Alcohol Scales

Martin, W. R., Sloan, J. W., Sapira, J. D., & Jasinski, D. R. (1971). Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man. Clinical Pharmacology and Therapeutics, 12(2), 245-258.

Marijuana Scale

Chait, L. D., & Perry, J. L. (1994). Acute and residual effects of alcohol and marijuana, alone and in combination, on mood and performance. Psychopharmacology, 115(3), 340-349.

General References

Haertzen, C. A. (1965). Addiction Research Center Inventory (ARCI): Development of a general drug estimation scale. Journal of Nervous and Mental Disease, 141, 300-307.

Haertzen, C. A., & Hickey, J. E. (1987). Addiction Research Center Inventory (ARCI): Measurement of euphoria and other drug effects. In M. A. Bozarth (Ed.), Methods of assessing the reinforcing properties of abused drugs (pp. 489-524). New York: Springer-Verlag.

Haertzen, C. A., Hill, H. E., & Belleville, R. E. (1963). Development of the Addiction Research Center Inventory (ARCI): Selection of items that are sensitive to the effects of various drugs. Psychopharmacologia, 4, 155-166.

Hill, H. E., Haertzen, C. A., Wolbach, A. B., Jr., & Miner, E. J. (1963). The Addiction Research Center Inventory: Standarization of scales which evaluate subjective effects of morphine, Amphetamine, pentobarbital, alcohol, LSD-25, pyrahexyl and chlorpromazine. Psychopharmacologia, 4, 167-183.

Kirk, J. M., Doty, P., & de Wit, H. (1998). Effects of expectancies on subjective responses to oral ∆9-tetrahydrocannabinol. Pharmacology, Biochemistry, and Behavior, 59, 287-293.

Preston, K. L., & Jasinski, D. R. (1991). Abuse liability studies of opioid agonist-antagonists in humans. Drug and Alcohol Dependence, 28(1), 49-82.

Wachtel, S. R., ElSohly, M. A., Ross, S. A., Ambre, J., & de Wit, H. (2002). Comparison of the subjective effects of ∆9-tetrahydrocannabinol and marijuana in humans. Psychopharmacology, 161, 331-339.

Protocol ID:

520101

Variables:
Export Variables
Variable NameVariable IDVariable DescriptionVersiondbGaP Mapping
PX520101_Answering_Questions_Is_Easy_Amphetamine PX520101060000 Answering these questions is very easy right now. 4 N/A
PX520101_Answering_Questions_Is_Easy_Benzedrine PX520101460000 Answering these questions is very easy right now. 4 N/A
PX520101_Anxious_And_Upset_LSD PX520101380000 I feel anxious and upset. 4 N/A
PX520101_Appreciate_What_Others_Say_Morphine PX520101170000 I can completely appreciate what others are saying when I am in this mood. 4 N/A
PX520101_Awareness_Of_Bodily_Sensations_LSD PX520101370000 I have an increasing awareness of my bodily sensations. 4 N/A
PX520101_Better_Control_Over_Myself_Benzedrine PX520101510000 I have better control over myself than usual. 4 N/A
PX520101_Body_Parts_Tingling_Amphetamine PX520101100000 Some parts of my body are tingling. 4 N/A
PX520101_Body_Parts_Tingling_Benzedrine PX520101490000 Some parts of my body are tingling. 4 N/A
PX520101_Body_Parts_Tingling_LSD PX520101310000 Some parts of my body are tingling. 4 N/A
PX520101_Body_Parts_Tingling_Marijuana PX520101750000 Some parts of my body are tingling. 4 N/A
PX520101_Difficulty_Remembering_Marijuana PX520101720000 I have difficulty in remembering. 4 N/A
PX520101_Don't_Feel_Like_Reading_Benzedrine PX520101540000 I don't feel like reading anything right now. 4 N/A
PX520101_Dragging_Along_Pentobarbital/Chlorpromazine/Alcohol PX520101570000 I have a feeling of just dragging along rather than coasting. 4 N/A
PX520101_Dull_Right_Now_Pentobarbital/Chlorpromazine/Alcohol PX520101640000 People might say I am a little dull right now. 4 N/A
PX520101_Fear_Lose_Contentment_Morphine PX520101150000 I fear I will lose the contentment that I have now. 4 N/A
PX520101_Feel_Drowsy_LSD PX520101280000 I feel drowsy. 4 N/A
PX520101_Feel_In_Complete_Harmony_Morphine PX520101160000 I feel in complete harmony with the world and those around me. 4 N/A
PX520101_Feel_Less_Discouraged_Amphetamine PX520101040000 I feel less discouraged than usual. 4 N/A
PX520101_Feel_Like_Avoiding_People_Pentobarbital/Chlorpromazine/Alcohol PX520101600000 I feel like avoiding people although I usually do not feel this way. 4 N/A
PX520101_Feel_Something_Pleasant_Happened_Morphine PX520101200000 I feel as if something pleasant had just happened to me. 4 N/A
PX520101_Feel_Very_Patient_Amphetamine PX520101090000 I feel very patient. 4 N/A
PX520101_Feel_Very_Patient_LSD PX520101300000 I feel very patient. 4 N/A
PX520101_Full_Of_Energy_Pentobarbital/Chlorpromazine/Alcohol PX520101660000 I am full of energy. 4 N/A
PX520101_Hands_Are_Shaking_Marijuana PX520101800000 I notice my hands are shaking. 4 N/A
PX520101_Happy_All_The_Time2_Morphine PX520101210000 I would be happy all the time if I felt as I do now. 4 N/A
PX520101_Happy_All_The_Time_LSD PX520101290000 I would be happy all the time if I felt as I do now. 4 N/A
PX520101_Happy_All_The_Time_Morphine PX520101180000 I would be happy all the time if I felt as good as I feel now. 4 N/A
PX520101_Harder_Move_Around_Pentobarbital/Chlorpromazine/Alcohol PX520101620000 It seems harder than usual to move around. 4 N/A
PX520101_Hard_To_Keep_Mind_Benzedrine PX520101530000 I find it hard to keep my mind on a task or job. 4 N/A
PX520101_Heart_Beating_Faster_Marijuana PX520101780000 I notice that my heart is beating faster. 4 N/A
PX520101_Increasing_Awareness_Of_Sensations_Marijuana PX520101810000 I have an increasing awareness of my bodily sensations. 4 N/A
PX520101_I_Am_Moody_Pentobarbital/Chlorpromazine/Alcohol PX520101630000 I am moody. 4 N/A
PX520101_I_Feel_Dizzy_Pentobarbital/Chlorpromazine/Alcohol PX520101610000 I feel dizzy. 4 N/A
PX520101_I_Feel_Drowsy_Pentobarbital/Chlorpromazine/Alcohol PX520101650000 I feel drowsy. 4 N/A
PX520101_I_Feel_Sluggish_Pentobarbital/Chlorpromazine/Alcohol PX520101580000 I feel sluggish. 4 N/A
PX520101_Less_Discouraged_Morphine PX520101270000 I feel less discouraged than usual. 4 N/A
PX520101_Little_Dull_Right_Now_Benzedrine PX520101420000 People might say I am a little dull right now. 4 N/A
PX520101_Memory_Seems_Sharpe_Benzedrine PX520101470000 My memory seems sharper to me than usual. 4 N/A
PX520101_More_Clear_Headed_Benzedrine PX520101430000 I feel more clear headed than dreamy. 4 N/A
PX520101_More_Clear_Headed_Pentobarbital/Chlorpromazine/Alcohol PX520101670000 I feel more clear headed than dreamy. 4 N/A
PX520101_More_Clear_Headed_Than_Dreamy_Morphine PX520101220000 I feel more clear headed than dreamy. 4 N/A
PX520101_More_Excited_Pentobarbital/Chlorpromazine/Alcohol PX520101680000 I feel more excited than dreamy. 4 N/A
PX520101_More_Excited_Than_Dreamy_Amphetamine PX520101050000 I feel more excited than dreamy. 4 N/A
PX520101_More_Pleasing_Than_Usual_Marijuana PX520101700000 Things around me seem more pleasing than usual. 4 N/A
PX520101_More_Popular_With_People_Amphetamine PX520101010000 I feel as if I would be more popular with people right now. 4 N/A
PX520101_More_Popular_With_People_Morphine PX520101230000 I feel as if I would be more popular with people right now. 4 N/A
PX520101_Mouth_Seems_Dry_Marijuana PX520101740000 My mouth seems very dry. 4 N/A
PX520101_Movements_Faster_Than_Usual_Benzedrine PX520101500000 My movements seem faster than usual. 4 N/A
PX520101_Movements_Free_Relaxed_Pleasurable_LSD PX520101410000 My movements are free, relaxed, and pleasurable. 4 N/A
PX520101_Movements_Seem_Slower_Benzedrine PX520101520000 My movements seem slower than usual. 4 N/A
PX520101_Movements_Seem_Slower_Marijuana PX520101770000 My movements seem slower than usual. 4 N/A
PX520101_My_Hands_Feel_Clumsy_LSD PX520101340000 My hands feel clumsy. 4 N/A
PX520101_My_Hand_Shakes_LSD PX520101350000 I notice my hand shakes when I write. 4 N/A
PX520101_My_Head_Feels_Heavy_Pentobarbital/Chlorpromazine/Alcohol PX520101590000 My head feels heavy. 4 N/A
PX520101_My_Memory_Seems_Sharper_Amphetamine PX520101070000 My memory seems sharper to me than usual. 4 N/A
PX520101_My_Speech_Is_Slurred_Pentobarbital/Chlorpromazine/Alcohol PX520101550000 My speech is slurred. 4 N/A
PX520101_Not_As_Active_Pentobarbital/Chlorpromazine/Alcohol PX520101560000 I am not as active as usual. 4 N/A
PX520101_Other_People_Can_Tell_Morphine PX520101190000 I feel so good that I know other people can tell it. 4 N/A
PX520101_Pleasant_Emptiness_Amphetamine PX520101020000 I feel a very pleasant emptiness. 4 N/A
PX520101_Pleasant_Emptiness_Marijuana PX520101730000 I feel a very pleasant emptiness. 4 N/A
PX520101_Pleasant_Emptiness_Morphine PX520101250000 I feel a very pleasant emptiness. 4 N/A
PX520101_Pleasant_Feeling_In_Stomach_Morphine PX520101140000 I have a pleasant feeling in my stomach. 4 N/A
PX520101_Say_Things_Easiest_Morphine PX520101120000 I feel as though I say things in the easiest possible way right now. 4 N/A
PX520101_Something_Pleasant_Happened_Marijuana PX520101710000 I feel as if something pleasant had just happened to me. 4 N/A
PX520101_Spending_Longer_On_Questions_LSD PX520101330000 It seems I am spending longer than I should on each of these questions. 4 N/A
PX520101_Stomach_Disturbance_LSD PX520101360000 I have a disturbance in my stomach. 4 N/A
PX520101_Talk_About_Feelings_Benzedrine PX520101450000 I am in the mood to talk about the feelings I have. 4 N/A
PX520101_Talk_About_Feelings_Morphine PX520101240000 I am in the mood to talk about the feelings I have. 4 N/A
PX520101_Things_Seem_More_Pleasing_Morphine PX520101130000 Things around me seem more pleasing than usual. 4 N/A
PX520101_Thoughts_Come_And_Go_Marijuana PX520101790000 My thoughts seem to come and go. 4 N/A
PX520101_Thoughts_Come_More_Easily_Amphetamine PX520101030000 My thoughts come more easily than usual. 4 N/A
PX520101_Thoughts_Come_More_Easily_Benzedrine PX520101440000 My thoughts come more easily than usual. 4 N/A
PX520101_Thoughts_Come_More_Easily_Morphine PX520101260000 My thoughts come more easily than usual. 4 N/A
PX520101_Thrill_Gone_Through_Me_LSD PX520101400000 A thrill has gone through me one or more times since I started this test. 4 N/A
PX520101_Thrill_Gone_Through_Me_Pentobarbital/Chlorpromazine/Alcohol PX520101690000 A thrill has gone through me one or more times since I started this test. 4 N/A
PX520101_Unusual_Muscle_Weakness_LSD PX520101390000 I have an unusual weakness in my muscles. 4 N/A
PX520101_Weird_Feeling_Amphetamine PX520101110000 I have a weird feeling. 4 N/A
PX520101_Weird_Feeling_LSD PX520101320000 I have a weird feeling. 4 N/A
PX520101_Weird_Feeling_Marijuana PX520101760000 I have a weird feeling. 4 N/A
PX520101_Write_For_Hours_Amphetamine PX520101080000 I feel as if I could write for hours. 4 N/A
PX520101_Write_For_Hours_Benzedrine PX520101480000 I feel as if I could write for hours. 4 N/A
Research Domain Information
Measure Name:

Acute Subjective Response to Substances - Current

Release Date:

February 24, 2012

Definition

Instruments used separately to assess current acute subjective responses to substances that the respondent has recently ingested or used.

Purpose

This measure is to assess a respondent’s feelings after recently smoking cigarettes, ingesting alcohol, or using drugs. The protocol is used to obtain subjective responses to the tobacco, alcohol, or drug administered. The Working Group recommends that investigators use the primary protocol to obtain general information on a variety of substances. The secondary protocols can then be used to obtain detailed information on a specific substance.

Keywords

Addiction Research Center Inventory, Adjective Checklist, Alcohol, Amphetamine, ARCI, BAES, Benzedrine, Biphasic Alcohol Effects Scale, Buzz, Cigarettes, Dizziness, DEQ, Drug Effects Questionnaire, Early Response, Irritable, LSD, Marijuana, mCEQ, modified Cigarette Evaluation Questionnaire, Morphine-Benzedrine, National Institute of Mental Health Addiction Research Center, Nausea, Pentobarbital-Chlorpromazine-Alcohol, Rush, SAA, Smoking, Substance Abuse, Substance-specific Intermediate Phenotypes