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Research Domain - Pregnancy

Adequacy of Prenatal Care

Kotelchuck Index, also called the Adequacy of Prenatal Care Utilization (APNCU)

Concentrations of Flame Retardants

National Children’s Study, Biospecimen Adult Blood Procedures: Standard Operating Procedures

National Health and Nutrition Examination Survey (NHANES), CDC Laboratory Procedure Manual, Polybrominated Diphenyl Ethers (PBDEs)

Concentrations of Phenols and Parabens

National Children’s Study (NCS), Biospecimen Adult Urine Procedures: Standard Operating Procedures

National Health and Nutrition and Examination Survey (NHANES) Laboratory Procedure Manual, Bisphenol A, Other Environmental Phenols, and Parabens in Urine

Concentrations of Polychlorinated Biphenyls (PCBs) and Persistent Pesticides

National Children’s Study, Biospecimen Adult Blood Procedures: Standard Operating Procedures

National Health and Nutrition Examination Survey, CDC Laboratory Procedure Manual, PCBs and Persistent Pesticides

Concentrations of Trace Metals

National Children’s Study Biospecimen Adult Blood Procedures: Standard Operating Procedures

National Health and Nutrition Examination Survey, CDC Laboratory Procedure Manual for Cadmium, Lead, Manganese, Mercury, and Selenium

Current Pregnancy Status - Bioassay

National Children’s Study, Biospecimen Adult Urine Procedures: Standard Operating Procedures

National Health and Nutrition Examination Survey (NHANES) Mobile Examination Center (MEC) Laboratory Procedures Manual

Current Pregnancy Status - Self-Report

National Health and Nutrition Examination Survey (NHANES) Reproductive Health Module

Difficulties in Pregnancy

Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-Be (nuMoM2b) Difficulties in Pregnancy Visit 1, Form V1E

Family History of Pregnancy Complications

Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-Be (nuMoM2b) Difficulties in Pregnancy, Maternal Interview Visit 2

Fetal Growth Assessment - Percentiles for U.S. Populations

Fetal Growth Standards Based on the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies

Gestational Age - Maternal Interview

Extremely Low Gestational Age Newborns (ELGAN) Study, Maternal Interview

Gestational Age - Medical Record Abstraction

Project Gestational Age

Gestational Diabetes

Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-Be (nuMoM2b): CLA Prenatal Labs

Health and Wellness Before, During, and After Pregnancy

Early Life Exposure Assessment Tool (ELEAT)

Mode of Conception - Interview

Pregnancy Risk Assessment Monitoring System (PRAMS) Phase 7 Core Questions and Standard Questions

Mode of Conception - Medical Record Abstraction

Extremely Low Gestational Age Newborns (ELGAN) Chart Abstraction Form

Mode of Delivery - Interview

Pregnancy Risk Assessment Monitoring System (PRAMS) Phase 7 Standard Questions

Mode of Delivery - Medical Record Abstraction

A Randomized Trial of Induction Versus Expectant Management (ARRIVE)

Prenatal and Postpartum Depression

The Edinburgh Postnatal Depression Scale© (EPDS)

The Pregnancy Working Group added the measures above to the PhenX Toolkit. They also identified additional measures in the PhenX Toolkit that are specifically related to research in this field. Toolkit users are encouraged to open, review and select measures in the Additional Relevant Measures folder.

Age of Initiation of First Cigarette Use - Adult

Tobacco Use Supplement to the Current Population Survey

Alcohol - 30-Day Quantity and Frequency

National Survey on Drug Use and Health, National Epidemiologic Survey on Alcohol and Related Conditions. Wave 1, Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV)

Alcohol - Age of First Use

2015 National Survey on Drug Use and Health (NSDUH)

Alcohol - Lifetime Use
Alcohol - Maximum Drinks in 24 Hours

National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III)

Assessment of Pubertal Development - Female

Avon Longitudinal Study of Parents and Children (ALSPAC). Growing and Changing (8), Female Teenage Questionnaire

Assessment of Pubertal Development - Male

Avon Longitudinal Study of Parents and Children (ALSPAC). Growing and Changing (8), Male Teenager Questionnaire

Birth Weight - Birth Weight Abstracted from Medical Records

Center for Disease Control and Prevention 2005-2006 National Vital Statistics System Birth Certificate Section

Birth Weight - Measured Weight at Birth

Global Network for Women’s and Children’s Health Research Manual of Operations

Birth Weight - Proxy Reported Birth Weight

2005-2006 National Health and Nutrition Examination Survey Questionnaire

Birthplace

American Community Survey (ACS), 2008

Birthplace of Grandparents

American Community Survey (ACS), 2008

Birthplace of Parents

American Community Survey (ACS), 2008

Birthplace of Parents

American Community Survey (ACS), 2008

Blood Pressure (Adult/Primary)
Causes and Treatments of Known Infertility - Female

National Survey of Family Growth (NSFG)

Causes and Treatments of Known Infertility - Male

National Survey of Family Growth (NSFG)

Child Head Circumference

2007-2008 National Health and Nutrition Examination Survey (NHANES) Anthropometry Procedures Manual

Cigarette Nicotine Dependence

Fagerstrom Test for Nicotine Dependence

Cigarette Smoking Status - Adolescent

Population Assessment of Tobacco and Health (PATH) Study Wave 3

Cigarette Smoking Status - Adult

Population Assessment of Tobacco and Health (PATH)

Current Contraception Use - Female

National Survey of Family Growth

Current Contraception Use - Male

National Survey of Family Growth (NSFG)

Current Environmental Tobacco Smoke Exposure

National Health and Nutrition Examination Survey (NHANES), 2007-2008 Family Questionnaire

Deep Venous Thrombosis
Depression Screener - Adults

Composite International Diagnostic Interview Screening Scales (CIDI-SC) 5.0 - Depression

Difficulty Getting Pregnant - Current Duration
Difficulty Getting Pregnant - Prospective Assessment

Pregnancy Study Online (PRESTO) Female Screener and Baseline Questionnaire

Difficulty Getting Pregnant - Retrospective Assessment
Existence of Cleft Lip or Palate
High Blood Pressure During Pregnancy
History of Prepubertal Development - Female

Black Women’s Health Study (BWHS)

History of Prepubertal Development - Male

Study for Future Families (SFF) and National Longitudinal Survey of Youth (NLSY)

Hormonal Therapy

Nurses’ Health Study II (NHS II)

Human Papillomavirus Vaccine Use

Behavioral Risk Factor Surveillance System (BRFSS)

Male Fertility Status

WHO Laboratory Manual for the Examination and Processing of Human Semen, Fifth Edition

Male Reproductive Tract Birth Defects

Study For Future Families

Male Sexual Function

Study for Future Families and International Index of Erectile Function (IIEF)

Menstrual History

Nurses’ Health Study (NHS), Black Women’s Health Study (BWHS), Study of Women Across the Nation (SWAN)

Oral Glucose Tolerance Test

[link[phenxtoolkit.org/toolkit_content/supplemental_info/diabetes/additional_info/NHANES_OGTT.pdf|2007-2008 National Health and Nutrition Examination Survey (NHANES) Oral Glucose Tolerance Test Manual]]

Ovulation History
Patterns of Substance Use - Adolescents

2015 Monitoring the Future (MTF)

Patterns of Substance Use - Adults - Binge-Drinking

National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III)

Personal and Family History of Strabismus
Personal History of Type 1 and Type 2 Diabetes

2001 Multi-Ethnic Study of Arthrosclerosis (MESA), Exam 1, Medical History

Pregnancy Status - Mother and Baby Health
Pregnancy Status and Tobacco Use
Prostate Symptoms

International Prostate Symptom Score (I-PSS)

Pulmonary Embolism
Removal of Female Reproductive Organs

National Survey of Family Growth (NSFG)

Reproductive History - Female

Women’s Interview Study of Health and Pregnancy Risk Assessment Monitoring System (PRAMS)

Screening and Severity of Substance Use Problems - Adolescents
Screening and Severity of Substance Use Problems - Adults - Alcohol - Lifetime

Brief Michigan Alcoholism Screening Test (Brief MAST)

Screening and Severity of Substance Use Problems - Adults - Alcohol - Past 12 Months

Alcohol Use Disorders Identification Test (AUDIT)

Screening and Severity of Substance Use Problems - Adults - Drugs

Drug Abuse Screening Test (DAST-10)

Serial Pregnancy Weight - Weights Measured During Gestation

American Congress of Obstetricians and Gynecologists (ACOG) Antenatal Form B and C

Serial Pregnancy Weight - Weights Measured During Gestation

American Congress of Obstetricians and Gynecologists (ACOG) Antenatal Form B and C

Serum Creatinine - Assay

2007 National Health and Nutrition Examination Survey (NHANES) Laboratory Procedures Manual

Substances - 30-Day Frequency

2015 National Survey on Drug Use and Health (NSDUH)

Substances - Age of First Use

2015 National Survey on Drug Use and Health (NSDUH)

Substances - Lifetime Use

National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III)

Tobacco (non-cigarette) - Product Use
Tobacco - 30-Day Quantity and Frequency - Adolescent

National Survey on Drug Use and Health (NSDUH)

Tobacco - 30-Day Quantity and Frequency - Adult

Tobacco Use Supplement to the Current Population Survey (TUS-CPS)

Tobacco - Age of Initiation of Use - Adolescent
Tobacco - Age of Offset of Cigarette Use - Adolescent

National Survey on Drug Use and Health (NSDUH)

Tobacco - Age of Offset of Cigarette Use - Adult

Tobacco Use Supplement to the Current Population Survey

Total Pregnancy Weight Gain - Abstracted From Prenatal Charts

ACOG Antenatal Form B and C

Total Pregnancy Weight Gain - Self-Reported Weight Gain

Pregnancy Risk Assessment Monitoring System (PRAMS) Phase 5 Topic Reference Questionnaire

Total Pregnancy Weight Gain - Weight Measured During Gestation

ACOG Antenatal Form B and C

Urinary Creatinine - Assay

2007 National Health and Nutrition Examination Survey (NHANES) Laboratory Procedures Manual, University of Minnesota Laboratory Procedures Manual for Urinary Creatinine

Urinary Microalbumin - Assay

2007 National Health and Nutrition Examination Survey (NHANES) Laboratory Procedures Manual, University of Minnesota Laboratory Procedures Manual for Urinary Albumin

Use of Tobacco Products
Weight Loss/Gain

2007-2008 National Health and Nutrition Examination Survey (NHANES) Weight History Questionnaire

Release Date:

January 31, 2017

Scope of Domain:
Scope Elements Final Measures To Toolkit
Gestational Age Gestational Age
Fetal Growth Fetal Growth Assessment
Mode of Delivery
  • Event that initiated immediate birth process
Mode of Delivery
Mode of Conception Mode of Conception
Pregnancy History
  • Live birthday, losses, etc
  • Family History
Current Pregnancy Status
Family History of Pregnancy Complications
Issues of Premature Delivery
  • Biomarkers, inflammation
Concentrations of Flame Retardants
Concentrations of Phenols and Parabens
Concentrations of Polychlorinated Biphenyls (PCBs) and Persistent Pesticides
Concentrations of Trace Metals
Biological responses to environment See biomarkers
Federated Bio-bank, Standardize Approaches (e.g., blood spot cards for environmental monitoring, DNA, collect hair, teeth to capture exposures) See biomarkers
Biomonitoring during Pregnancy and other Sensors See biomarkers
Prenatal Care
  • Provider visits
  • Social Media
  • Personal behavior during pregnancy: physical activity, diet sleep
Adequacy of Prenatal Care
Health and Wellness Before, During, and After Pregnancy
Exposures during Pregnancy
  • Developmental toxicants
  • Smoking, including second hand smoke
  • Alcohol during pregnancy
See biomarkers
Addressed elsewhere in the PhenX Toolkit
Pharmacological
  • antibiotic use, psychotropic medications, antiepileptic medications
Addressed elsewhere in the PhenX Toolkit
Placental Characteristics Placental Assessment (Supplemental Information)
Complications of Pregnancy
  • Growth restriction
Difficulties in Pregnancy
Diabetes, Pre-eclampsia Gestational Diabetes
Pregnancy Weight Gain: Total and Serial Addressed elsewhere in the PhenX Toolkit
Pre-pregnancy BMI, Weight, Height Addressed elsewhere in the PhenX Toolkit
Diet Addressed elsewhere in the PhenX Toolkit
Nutrients – Vitamins, Folic Acid, Other Supplements Addressed elsewhere in the PhenX Toolkit
Psychological/psychiatric Conditions Prenatal and Postpartum Depression
Psychological Stress Addressed elsewhere in the PhenX Toolkit
Working Group Roster:

WG Members:

Siobhan Dolan, MD, MPH, Chair
Albert Einstein College of Medicine
Bronx, NY
Cande Ananth, PhD
Columbia University
New York, NY
Patrick Catalano, MD
Case Western Reserve University
MetroHealth Medical Center
Cleveland, OH
Ann Kinga Malinowski, MD
Mount Sinai Hospital
Toronto, ON
Russ Kirby, PhD
University of South Florida
Tampa, FL
Mark Klebanoff, MD, MPH
Nationwide Children’s Hospital
Columbus, OH
Hyagriv Simhan, MD, MS
Magee-Women's Research Institute
Pittsburgh, PA
Erin Hines, PhD
U.S. Environmental Protection Agency
Research Triangle Park, NC
John J. Mulvihill, MD
National Human Genome Research Institute (NHGRI)
Bethesda, MD

SC Liaison, WG Manager and WG Supervisor:

Rosalind J. Wright, MD, MPH, SC Liaison
Icahn School of Medicine
New York, NY
Lisa Kilpatrick, MS, WG Manager
RTI International
Atlanta, GA
Michael Phillips, MS, WG Supervisor
RTI International
Research Triangle Park, NC
Protocol Name Status DCW DD DD Mapping