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Research Domain - Respiratory

Arterial Blood Gas (ABG)

Blood Gas Analysis and Hemoximetry

Biomarker of exposure to nicotine-containing products - Saliva

Saliva cotinine levels as a function of collection method

Biomarker of exposure to nicotine-containing products - Serum

National Health and Nutrition Examination Survey (NHANES) Cotinine Analysis

Biomarker of exposure to nicotine-containing products - Urine
Bronchodilator Responsiveness (BDR)

COPDGene Study Clinical Center Manual of Procedures

Chest Computed Tomography (CT)

COPDGene Study

Exercise Capacity/Six-Minute Walk Test

Six-Minute Walk Test (6MWT)

Immunoglobulin E (Total and Specific)
Peak Expiratory Flow Rate (PEFR)
Personal and Family History of Respiratory Symptoms/Diseases - Adult

American Thoracic Society-Division of Lung Diseases Questionnaire (ATS-DLD 78) and Genetic Epidemiology of COPD Study (COPDGene)

Personal and Family History of Respiratory Symptoms/Diseases - Child

The International Study of Asthma and Allergies in Childhood (ISAAC) Manual

Pulse Oximetry (Exercise)
Pulse Oximetry (Rest)

World Health Organization (WHO) Pulse Oximetry Training Manual

Quality of Life as Affected by Respiratory Disease

St. George’s Respiratory Questionnaire (SGRQ)

Respiratory Rate - Adult
Respiratory Rate - Child
Respiratory Rate - Infant
Sleep Apnea - Adult

Berlin Questionnaire

Sleep Apnea - Child

The Pediatric Sleep Questionnaire (PSQ)

Spirometry - Adult

Spirometry

Spirometry - Child

Pulmonary Function Testing in Preschool and School Age Children

Release Date:

January 29, 2010; reviewed November 17, 2017

Scope of Domain:
Scope Elements Final Measures To Toolkit
Personal History of Conditions and Symptoms
Pneumonia, sarcoidoses Personal and Family History of Respiratory Symptoms/Diseases (Adult and Child)
Chronic obstructive pulmonary disease (COPD) Personal and Family History of Respiratory Symptoms/Diseases (Adult and Child)
Lung cancer
Symptoms, such as wheezing, shortness of breath Quality of Life as Affected by Respiratory Disease
Trauma (acute respiratory disorder)
Allergic reactions to drugs
Anemia
Bronchitis, pleurisy Personal and Family History of Respiratory Symptoms/Diseases (Adult and Child)
Asthma Personal and Family History of Respiratory Symptoms/Diseases (Adult and Child)
Sleep apnea, sleep Sleep Apnea
History of prematurity and early respiratory infections Personal and Family History of Respiratory Symptoms/Diseases (Adult and Child)
Pediatric lung diseases, newborn
Risk factors (past and present)
Exposures Cotinine
Geographic history of patient (histoplasmosis)
Institutional residence (prisoner, nursing home)
Family history (see Personal history of conditions and symptoms) Personal and Family History of Respiratory Symptoms/Diseases (Adult and Child)
Biologic and physiologic assessments
Infectious organisms (pneumococci, staphylococci, gram-negative bacilli
Opportunistic microbes (candida, aspergillus, cytomegalovirus)
Manifestations (dyspnea, cough, hemoptysis [blood in sputum], abnormal production of sputum, cyanosis [bluish discoloration of skin], thoracic pain [pleuritic, pulmonary, chest wall, cardiac], fever)
Blood dyscrasia
Lipoid pneumonia caused by nose drops
Klebsiella pneumonia in chronic alcoholics
Pulmonary function tests (PFT) for: obstructive disease of the airways; restrictive lung disease; alveolar hypoventilation due to malfunctioning of the chest bellows or control mechanisms; and obliterative vascular disease. Original element broken into three specific measures: Spirometry, Peak Expiratory Flow Rate (PEFR), and Bronchodilator Responsiveness (BDR)
Pulmonary embolism
Treatments and procedures (past and present)
Radiologic evaluation (chest X-ray or CXR)
Drug treatments
Chest Computed Tomography (CT)
Cotinine
Immunoglobulin E (Total and Specific)
Pulse Oximetry (rest)
Pulse Oximetry (exercise)
Included as a supplemental measure
Arterial Blood Gas (ABG)
Exercise Capacity/Six-Minute Walk Test
Allergy Skin Prick Test (Supplmental)
Working Group Roster:

WG Members:

Edwin (Ed) K. Silverman, MD, PhD, Chair
Brigham and Women's Hospital
Harvard Medical School (Channing Laboratory)
Boston, MA
F. Sessions Cole, III, MD
Washington University in St. Louis
School of Medicine, Department of Pediatrics
St. Louis, MO
Jason D. Christie, MD
University of Pennsylvania
Philadelphia, PA
Gang Dong, MD, PhD
National Institute of Allergy and Infectious Diseases (NIAID)
Division of Allergy, Immunology, and Transplantation (DAIT)
Bethesda, MD
James (Jim) E. Loyd, MD
Vanderbilt University
School of Medicine (Division of Pulmonology)
Nashville, TN
Geoffrey McLennan, MB, BS, FRACP, PhD
University of Iowa
Iowa City, IA
Gail G. Weinmann, MD
National Heart, Lung, and Blood Institute (NHLBI)
Division of Lung Diseases
Bethesda, MD

SC Liaison, WG Manager and WG Supervisor:

Terri H. Beaty, PhD, SC Liaison
Johns Hopkins University
School of Public Health
Baltimore, MD
Jennifer Lyden, MPH, WG Manager
RTI International
Statistics and Epidemiology Division
Research Triangle Park, NC
Lisa Strader, MPH, WG Supervisor
RTI International
Research Triangle Park, NC
Expert Review Panel 6 - Respiratory domain:

ERP Members:

David M. Mannino, MD
University of Kentucky College of Public Health
Lexington, KY
Stephanie D. Davis, MD
Indiana University SChool of Medicine
Indianapolis, IN

SC Liaison, ERP Manager and ERP Supervisor:

Daniel R. Masys, MD, FACMI, SC Liaison
University of Washington, Seattle
School of Medicine
Seattle, WA
Stacie White, BS, ERP Manager
RTI International
Research Triangle Park, NC
Michael Phillips, MS, ERP Supervisor
RTI International
Research Triangle Park, NC
Respiratory Supplemental Information includes:
Additional Information for Respiratory Measures: