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Research Domain - Smoking Cessation, Harm Reduction and Biomarkers

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Shiffman, S., et al. Analyzing milestones in smoking cessation: illustration in a nicotine patch trial in adult smokers. J Consult Clin Psych, 2006.
#330101

Heaviness of Smoking Index (HSI)
#330201

Caraballo RS, et al. Quit Methods Used by US Adult Cigarette Smokers, 2014-2016. Prev Chronic Dis, 2017.
#330301

National Health and Nutrition Examination Survey (NHANES) Cotinine and Hydroxycotinine Analysis
#330401

Population Assessment of Tobacco and Health (PATH) Study, PATH Wave 3 Adult Annotated Instrument, 2018
#330501

Population Assessment of Tobacco and Health (PATH) Study, PATH Waves 1 and 3 Adult Annotated Instrument, 2016-2018
#330503

Population Assessment of Tobacco and Health (PATH) Study, PATH Wave 1 Adult Annotated Instrument, 2016
#330502

Population Assessment of Tobacco and Health (PATH) Study, PATH Wave 1 Adult Annotated Instrument, 2016 
#330504

Population Assessment of Tobacco and Health (PATH) Study, PATH Waves 1 and 3 Adult Annotated Instrument, 2016-2018
#330505

Smoking Self-Efficacy Questionnaire (SEQ-12)
#330801

Partner Interaction Questionnaire (PIQ-20)
#330901
Amount, Type, and Frequency of Recent Cigarette Use
The Timeline Followback (TLFB)
Biological Sex Assigned at Birth
All of Us Research Program, Participant Provided Information (PPI), 2018
Biomarker of exposure to nicotine-containing products - Saliva
Schneider, NG, et al. Saliva cotinine levels as a function of collection method. Addiction, 1997
Biomarker of exposure to nicotine-containing products - Serum
National Health and Nutrition Examination Survey (NHANES), Cotinine Analysis, 2011-2012
Biomarker of exposure to nicotine-containing products - Urine
Man, C. N., et al, Simple, rapid and sensitive assay method for simultaneous quantification of urinary nicotine and cotinine using gas chromatography-mass spectrometry, J CHROMATOGR, 2006
Current Age
National Health and Nutrition Examination Survey (NHANES), 2005-2006
Ethnicity and Race
U.S. Census Bureau, Census 2020, Questionnaire
Expired Carbon Monoxide
Sandberg, A, et al, Assessing recent smoking status by measuring exhaled carbon monoxide levels. PLOS ONE, 2011
Gender Identity
All of Us Research Program, Participant Provided Information (PPI), 2018
Heaviness of Smoking Index
Heaviness of Smoking Index (HSI)
Motivation to Quit - Multiple Item
The Reasons for Quitting (RFQ) Questionnaire
Motivation to Quit - Single Item
Turner, L.R., et al. Motivation and reasons to quit: Predictive validity among adolescent smokers. AM J HEALTH BEHAV, 2004
Self-Efficacy for Not Smoking
Smoking Self-Efficacy Questionnaire (SEQ-12)
Smoking Quit Attempts
Prostate, Lung, Colorectal and Ovarian (PLCO), Cancer Screening Trial, Supplemental Questionnaire, 1/06
Age of Initiation of First Cigarette Use - Adult
Co-sponsored Tobacco Use Supplement to the Current Population Survey, 2010
Cigarette Smoking Status - Adolescent
Population Assessment of Tobacco and Health (PATH) Study Wave 3
Cigarette Smoking Status - Adult
Population Assessment of Tobacco and Health (PATH) Study Wave 1
History of Switching to Lower Tar and Nicotine Cigarettes
National Health Interview Survey (NHIS), sample adult cancer supplement questionnaire, 2000
Nicotine Content
Tobacco Laboratory, Nicotine (Total and Unprotonated), Version 03
NNAL in Urine
Passive Exposures to Tobacco Products
Passive Smoke Exposure
Molecular Epidemiology Case-Series Study of Non-Small Cell Lung Cancer in Smoking and Non-Smoking Women and Men
Personal Perception and Knowledge of Smoking-related Cancer Risk
Prostate, Lung, Colorectal and Ovarian (PLCO), Cancer Screening Trial, Supplemental Questionnaire, 1/06
Social Norms about Tobacco - Adult
Population Assessment of Tobacco and Health (PATH) Study, Wave 1, Adult Extended Interview 7.5
Social Norms about Tobacco - Youth
Population Assessment of Tobacco and Health (PATH) Study, Wave 1, Youth Extended Interview and Adult Extended Interview 7.5
Susceptibility to Tobacco Products
Population Assessment of Tobacco and Health (PATH) Study
Tobacco (non-cigarette) - Product Use
National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), Wave 1
Tobacco - 30-Day Quantity and Frequency - Adolescent
National Survey on Drug Use and Health (NSDUH), 2014
Tobacco - 30-Day Quantity and Frequency - Adult
Tobacco Use Supplement to the Current Population Survey (TUS-CPS), 2010
Tobacco - Age of Initiation of Use - Adolescent
National Survey on Drug Use and Health (NSDUH), 2008
Tobacco - Age of Offset of Cigarette Use - Adolescent
National Survey on Drug Use and Health (NSDUH), 2015
Tobacco - Age of Offset of Cigarette Use - Adult
Tobacco Use Supplement to the Current Population Survey (TUS-CPS), 2006
Tobacco Brand and Variety - Cigarettes
National Survey on Drug Use and Health (NSDUH), 2014
Tobacco Brand and Variety - Cigars
Current Population Survey (CPS), Tobacco Supplement, 2010-2011
Tobacco Brand and Variety - Smokeless Tobacco
Population Assessment of Tobacco and Health (PATH), Wave 1 Adult Extended Questionnaire, Version 7.5 and Individual Screener 7.5
Tobacco Product Adulteration - Vent or Filter Blocking
Kozlowski, L.T., et al, Smokers are unaware of the filter vents now on most cigarettes: results of a national survey. TOB CONTROL, 1996
Tobacco Warning Label Exposure and Recall
Population Assessment of Tobacco and Health (PATH), Adult Extended Questionnaire, Version 7.5 & International Tobacco Control 4-Country Survey, 2015
Use of Tobacco Products
Population Assessment of Tobacco and Health (PATH) Study, Wave 1 Adult Extended Interview 7.5 and Individual Screener 7.5
Adipocytokines
National Health and Nutrition Examination Survey Questionnaire (NHANES), Laboratory Procedures Manual, 2007
Birth Weight - Measured Weight at Birth
Krebs, N. F., et al. Complementary feeding: A Global Network cluster randomized controlled trial manual of operations, BMC PEDIATR, 2011
Blood Pressure (Adult/Primary)
Coronary Artery Risk Development in Young Adults (CARDIA), Y20 CARDIA VII & Framingham Heart Study (FHS), Generation 3
Cancer: Personal and Family History
The California Teachers Study, Follow Up Survey 4, 2005-2006
Fasting Serum Insulin
National Health and Nutrition Examination Survey (NHANES), Laboratory Procedures Manual, 2007
Gestational Age - Maternal Interview
Boston Medical Center, Extremely Low Gestational Age Newborns (ELGAN) Study, Maternal Interview, 2002
History of Stroke - Ischemic Infarction and Hemorrhage
Jackson Heart Study (JHS)
Myocardial Infarction
Cardiovascular Health Study (CHS), Baseline Medical History Questionnaire & Womens Health Initiative (WHI), Medical History Update
Peak Expiratory Flow Rate (PEFR)
Miller, M. R., et al, Standardization of spirometry. Series “ATS/ERS task force: Standardization of lung function testing.”, EUR RESPIR J, 2005
Periodontal Disease - Prevalence
Hispanic Community Health Study (HCHS), Oral Health Assessment
Personal and Family History of Respiratory Symptoms/Diseases - Adult
American Thoracic Society-Division of Lung Diseases Questionnaire (ATS-DLD 78) & Genetic Epidemiology of COPD Study (COPDGene)
Personal and Family History of Respiratory Symptoms/Diseases - Child
International Study of Asthma and Allergies in Childhood (ISAAC) Manual
Personal History of Allergies, Infectious Diseases, and Immunizations - Adult
My Personal Health Record (MyPHR), Adult PHR Form, 2006
Personal History of Type I and Type II Diabetes
Multi-Ethnic Study of Arthrosclerosis (MESA), Exam 1, Medical History, 2001
Personal Medical History of Allergies, Infectious Diseases, and Immunizations - Child
My Personal Health Record (MyPHR), Child PHR Form, 2006
Pulmonary Embolism
Womens Health Initiative (WHI) & Cardiovascular Health Study (CHS)
Respiratory Rate - Adult
Potter, P. A., et al. Fundamentals of Nursing, 1985
Respiratory Rate - Child
Wallis, L. A., Healy, et al, Age related reference ranges for respiration rate and heart rate from 4 to 16 years, ARCH DIS CHILD, 2005
Spirometry - Adult
Miller, M. R., et al, Standardization of spirometry. Series “ATS/ERS task force: Standardization of lung function testing.”, EUR RESPIR J, 2005
Spirometry - Child
Beydon, N., et al, An official American Thoracic Society/European Respiratory Society statement: Pulmonary function testing in preschool children, AM J RESP CRIT CARE, 2007
Weight Loss/Gain
National Health and Nutrition Examination Survey (NHANES), Weight History Questionnaire, 2007
Release Date:

February 23, 2021

Scope of Domain:
Scope Elements Final Protocols To Toolkit (13)
Biomarkers Nicotine Metabolite Ratio – Serum and Saliva
Mechanism of Cessation/Outcomes Cessation Milestones: Abstinence from Cigarettes
Mediators of Treatment Effects Perception of Tobacco Product Risk – Cigarettes*
Mediators of Treatment Effects Perception of Tobacco Product Risk – Cigars*
Mediators of Treatment Effects Perception of Tobacco Product Risk – E-Cigarettes*
Mediators of Treatment Effects Perception of Tobacco Product Risk – Pipe Tobacco*
Mediators of Treatment Effects Perception of Tobacco Product Risk – Smokeless Tobacco*
Risk Factors Heaviness of Smoking - Cigarettes
Risk Factors Self-Efficacy for Not Smoking
Risk Factors Social Support for Quitting Smoking
Treatment Adherence to Smoking Cessation Medication – Self-Report
Treatment Methods of Quitting Smoking Cigarettes – Adults
*Perception of Tobacco Product Risk assesses both Mediators of Treatment Effects and Risk Factors.
Working Group Roster:

WG Members:

Laura J. Bierut, MD, Co-Chair
Washington University in St. Louis
St. Louis, MO
Gary E. Swan, PhD, Co-Chair
Stanford University School of Medicine
Stanford, CA
Neal L. Benowitz, MD
University of California, San Francisco
San Francisco, CA
K. Michael Cummings, PhD, MPH
Medical University of South Carolina
Charleston, SC
Robin J. Mermelstein, PhD
University of Illinois at Chicago
Institute for Health Research and Policy
Chicago, IL
Megan E. Piper, PhD
University of Wisconsin, Madison
Madison, WI
Scott I. Vrieze, PhD
University of Minnesota
Minneapolis, MN
Theodore Wagener, PhD
The Ohio State University
Columbus, OH

SC Liaison, WG Manager and WG Supervisor:

Tabitha P. Hendershot, BA, SC Liaison
RTI International
Washington, DC
Cataia Ives, MS, WG Manager
RTI International
Research Triangle Park, NC
Mark Nelms, PhD, WG Supervisor
RTI International
Research Triangle Park, NC
Smoking Cessation, Harm Reduction and Biomarkers Supplemental Information includes:

There is no supplemental information for this domain.

Additional Information for Smoking Cessation, Harm Reduction and Biomarkers Measures:

There is no additional information for this domain.

Protocol Name Status DCW DD DD Mapping
Select Measure Name Protocols
Cessation Milestones - Abstinence from Cigarettes Cessation Milestones - Abstinence from Cigarettes
Heaviness of Smoking - Cigarettes Heaviness of Smoking Index
Methods of Quitting Smoking Cigarettes - Adults Methods of Quitting Smoking Cigarettes - Adults
Nicotine Metabolite Ratio - Serum and Saliva Nicotine Metabolite Ratio - Serum and Saliva
Perception of Tobacco Product Risk Perception of Tobacco Product Risk - Cigarettes
Perception of Tobacco Product Risk - E-Cigarettes
Perception of Tobacco Product Risk - Cigars
Perception of Tobacco Product Risk - Pipe Tobacco
Perception of Tobacco Product Risk - Smokeless Tobacco
Point-prevalence Abstinence from Cigarettes Point-prevalence Abstinence from Cigarettes
Prolonged Abstinence from Cigarettes Prolonged Abstinence from Cigarettes
Self-Efficacy for Not Smoking Self-Efficacy for Not Smoking
Social Support for Quitting Smoking Social Support for Quitting Smoking