Protocol - Biological Sex Assigned at Birth

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Participants (or proxy) indicate the biological sex assigned at birth. It can be self-administered or interviewer administered.

Specific Instructions

This protocol can be used in conjunction with the Gender Identity protocol. This use of the protocol may be preferred to allow a research participant to differentiate their biological sex assigned at birth with how they currently define their gender. 


What was your biological sex assigned at birth?

[ ] Female

[ ] Male

[ ] Intersex

[ ] None of these describe me (optional free text)

[ ] Prefer not to answer



Personnel and Training Required


Equipment Needs

The PhenX Steering Committee acknowledges these questions can be administered in a computerized or noncomputerized format (i.e., paper-and-pencil instrument). Computer software is necessary to develop computer-assisted instruments. The interviewer will require a laptop computer/handheld computer to administer a computer-assisted questionnaire.

Requirement CategoryRequired
Major equipment No
Specialized training No
Specialized requirements for biospecimen collection No
Average time of greater than 15 minutes in an unaffected individual No
Mode of Administration

Self-administered or interviewer-administered questionnaire


Adult, Senior


Adults 18 years and older

Selection Rationale

This protocol was selected because it is both the most up-to-date and in use by the national All of Us research program.


English, Other languages available at source

caDSR Common Data Elements (CDE) Person Gender Text Type 2200604 CDE Browser
Derived Variables


Process and Review

Not applicable.

Protocol Name from Source

All of Us Research Program, Participant Provided Information (PPI), 2018


All of Us Research Program Participant Provided Information (PPI) Version: December 17, 2018

General References

The Precision Medicine Initiative Cohort Program – Building a Research Foundation for 21st Century Medicine Precision Medicine Initiative (PMI) Working Group Report to the Advisory Committee to the Director, NIH September 17, 2015

Collins, F. S. and Varmus, H. (2015). A New Initiative on Precision Medicine. N Engl J Med, 372, 793-795

National Research Council. Toward precision medicine: building a knowledge network for biomedical research and a new taxonomy of disease. Washington, DC: National Academies Press, 2011 (http://www.nap.edu/catalog/13284/toward-precision-medicine-building-a-knowledge-network-for-biomedical-research).

The GenIUSS Group. (2014). Best Practices for Asking Questions to Identify Transgender and Other Gender Minority Respondents on Population-Based Surveys. J.L. Herman (Ed.). Los Angeles, CA: The Williams Institute.

Protocol ID


Export Variables
Variable Name Variable IDVariable DescriptiondbGaP Mapping
PX011601010100 What was your biological sex assigned at birth? N/A
PX011601010200 What was your biological sex assigned at more
birth? Other show less
Measure Name

Biological sex assigned at birth

Release Date

June 4, 2019


The indication of the biological sex assigned to an individual at the time of birth. This usually aligns with a person’s anatomical sex, chromosomal sex, and phenotype.


Biological sex is an important piece of demographic information impacting many health outcomes.


biological sex assigned at birth, female, male, Intersex, gender, Demographics-Populations with HD

Measure Protocols
Protocol ID Protocol Name
11601 Biological Sex Assigned at Birth