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Protocol - Substances - Lifetime Use

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Description:

Measurement of respondents lifetime use of illicit and prescribed substances.

Specific Instructions:

Respondents will answer yes or no to the following list of drugs. If he or she indicates that he or she has used a specific drug (even experimentally), the interviewer will query for the specific drug(s) used. Note that the protocol specified below has been adapted so that the names of the drug categories are listed as noted in Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) survey (see Source below). In Wave 1, each drug category was phonetically spelled out for the interviewer.

Protocol:

The Working Group acknowledges that the following questions may gather sensitive information relating to the use of substances and/or illegal conduct. If the information is released it might be damaging to an individuals employability, lead to social stigmatization, or other consequences.

For information on obtaining a Certificate of Confidentiality, which helps researchers protect the privacy of human research participants, please go to the National Human Genome Research Institutes Institutional Review Board website.

The following questions are asked of the respondent. First read the introductory paragraph to the respondent. Show the respondent the flashcard (provided below) and read to the respondent the list of drug categories (items 1-10). If the respondent answers "Yes" to any drug category, ask Which ones? Record the specific drug(s) used.

Now Id like to ask you about your experiences with medicines and other kinds of drugs that you may have used ON YOUR OWN - that is, either WITHOUT a doctors prescription (PAUSE); in GREATER amounts, MORE OFTEN, or LONGER than prescribed (PAUSE); or for a reason other than a doctor said you should use them. People use these medicines and drugs ON THEIR OWN to feel more alert, to relax or quiet their nerves, to feel better, to enjoy themselves, or to get high or just to see how they would work.

Have you EVER used any of these medicines or drugs?

[ ] 1 Sedatives, for example, sleeping pills, barbiturates, Seconal®, Quaaludes, or Chloral Hydrate - Specify ↓

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[ ] 2 Tranquilizers or anti-anxiety drugs, for example, Valium®, Librium®, muscle relaxants, or Zanax® - Specify ↓

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[ ] 3 Painkillers, for example, Codeine, Darvon®, Percodan®, OxyContin®, Dilaudid®, Demerol®, Celebrex®, or Vioxx® - Specify ↓

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[ ] 4 Stimulants, for example, Preludin®, Benzedrine®, Methedrine®, Ritalin®, uppers, or speed - Specify ↓

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[ ] 5 Marijuana, hash, THC, or grass - Specify ↓

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[ ] 6 Cocaine or crack - Specify ↓

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[ ] 7 Hallucinogens, for example, Ecstasy/MDMA, LSD, mescaline, psilocybin, PCP, angel dust, or peyote - Specify ↓

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[ ] 8 Inhalants or solvents, for example, amyl nitrite, nitrous oxide, glue, toluene or gasoline - Specify ↓

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[ ] 9 Heroin

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[ ] 10 Any OTHER medicines, or drugs, or substances, for example, methadone, Elavil®, steroids, Thorazine®, or Haldol®? - (SELECT MOST FREQUENTLY USED OTHER DRUG)

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The following supplemental flashcard has been revised from the original to reflect the ten drug categories listed in the Alcohol Use Disorder and Associated Disabilities Interview Schedule Fourth Edition Version (AUDADIS-IV) instrument.*

Flashcard

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TYPES OF MEDICINES/DRUGS

1. Sedatives, for example, sleeping pills, barbiturates, Seconal®, Quaaludes®, or Chloral Hydrate®

2. Tranquilizers or anti-anxiety drugs, for example, Valium®, Librium®, muscle relaxants, or Zanax®

3. Painkillers, for example, Codeine, Darvon®, Percodan®, Dilaudid®, or Demerol®

4. Stimulants, for example, Preludin®, Benzedrine®, Methadrine®, uppers, or speed

5. Marijuana, hash, THC, or grass

6. Cocaine or crack

7. Hallucinogens, for example, Ecstasy, LSD, mescaline, psilocybin, PCP, angel dust, or peyote

8. Inhalants or Solvents, for example, amyl nitrate, nitrous oxide, glue, tolune, or gasoline

9. Heroin

10. Any OTHER medicines, drugs, or substances, for example, Methadone®, Elavi®l, steroids, Thorazine®, or Haldol®

* The original Wave 1 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) instrument had ten categories for the lifetime substance use question: Categories 1-8 listed above, along with two additional slots where the respondent could name one of the "other" drugs (including heroin). While editing the data from the Wave 1 responses, the National Institute on Alcohol Abuse and Alcoholism (NIAAA) determined a single category for heroin would be appropriate, leaving only one field for coding "other" drugs. The Alcohol Use Disorder and Associated Disabilities Interview Schedule Fourth Edition Version (AUDADIS - IV) was modified to create a separate category 9 for heroin and a category 10 for other drugs and edited the AUDADIS questionnaire to reflect this change.

Seconal® a registered trademark, Eli Lilly and Company; Valium® a registered trademark, Hoffman LaRoche Inc.; Librium® a registered trademark, Valeant Pharmaceuticals International; Zanax® a registered trademark, UpJohn Company; Darvon® a registered trademark, Eli Lilly and Company; Percodan® a registered trademark, ENDO Pharmaceuticals, Inc.; OxyContin® a registered trademark, Purdue Pharma, LP; Dilaudid® a registered trademark, Purdue Pharma, LP; Demerol® a registered trademark, Sanofi-Aventis Group; Celebrex® a registered trademark, G.D. Searle & Co.; Vioxx® a registered trademark, Merck & Co., Inc.; Preludin® a registered trademark, Boehringer-Ingelheim; Benzedrine® a registered trademark, GlaxoSmithKline; Methedrine® a registered trademark, GlaxoSmithKline; Ritalin® a registered trademark, Novartis Pharmaceuticals Corp.; Elavil® a registered trademark, Astra Zeneca Pharmaceuticals., Inc; Thorazine® a registered trademark, GlaxoSmithKline; Haldol® a registered trademark, Ortho-McNeil Pharmaceutical, Inc.

Protocol Name from Source:

The Expert Review Panel has not reviewed this measure yet.

Availability:

Publicly available

Personnel and Training Required

Interviewer must be trained and found competent to conduct personal interviews with individuals from the general population. The interviewer should be trained to prompt respondents further if a "dont know" response is provided.

Equipment Needs

While the Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV) instrument was developed for administration by computer, the PhenX Working Group acknowledges that these questions can be administered in a noncomputerized format. Hasin et al. (1997) and Grant et al. (1995) used the AUDADIS in paper-and-pencil format, while Grant et al. (2003) obtained data with the computerized format.

Requirements
Requirement CategoryRequired
Major equipment No
Major equipment No
Specialized training No
Specialized training No
Specialized requirements for biospecimen collection No
Specialized requirements for biospecimen collection No
Average time of greater than 15 minutes in an unaffected individual No
Average time of greater than 15 minutes in an unaffected individual No
Mode of Administration

Interviewer-administered questionnaire

Life Stage:

Adult, Adult

Participants:

≥18 years

Selection Rationale

The protocol from the Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS) was chosen because it was used in a large epidemiological study containing adults with a wide age range and different ethnicities (Wave 1 included 43,093 Americans; in Wave 2, 34,653 members of the original cohort were reinterviewed). The measures from this survey have been validated and psychometrically tested.

Language

English, English, Available in other languages, Available in other languages

Standards
StandardNameIDSource
Common Data Elements (CDE) Person Substance of Abuse Consumption Indicator 2821039 CDE Browser
Logical Observation Identifiers Names and Codes (LOINC) Substance - lifetime use proto 62505-3 LOINC
Derived Variables

None

Process and Review

The Expert Review Panel has not reviewed this measure yet.

Source

National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Epidemiologic Survey on Alcohol and Related Conditions. Wave 1 (NESARC - WAVE 1). Alcohol Use Disorder and Associated Disabilities Interview Schedule - Diagnostic and Statistical Manual of Mental Disorders. Fourth Edition Version (AUDADIS-IV), Section 3B (question 1a).

Grant, B. F., Dawson, D. A., Stinson, F. S., Chou, P. S., Kay, W., & Pickering, R. (2003). The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV): Reliability of alcohol consumption, tobacco use, family history of depression and psychiatric diagnostic modules in a general population sample. Drug and Alcohol Dependence, 71(1), 7-16.

General References

Grant, B. F., Dawson, D. A., Stinson, F. S., Chou, P. S., Kay, W., & Pickering, R. (2003). The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV): Reliability of alcohol consumption, tobacco use, family history of depression and psychiatric diagnostic modules in a general population sample. Drug and Alcohol Dependence, 71(1), 7-16.

Grant, B. F., Harford, T. C., Dawson, D. A., Chou, P. S., & Pickering, R. P. (1995). The Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS): Reliability of alcohol and drug modules in a general population sample. Drug and Alcohol Dependence, 39(1), 37-44.

Hasin, D., Carpenter, K. M., McCloud, S., Smith, M., & Grant, B. F. (1997). The alcohol use disorder and associated disabilities interview schedule (AUDADIS): Reliability of alcohol and drug modules in a clinical sample. Drug and Alcohol Dependence, 44(2-3), 133-141.

Protocol ID:

31101

Variables:
Export Variables
Variable NameVariable IDVariable DescriptionVersiondbGaP Mapping
Alcohol, Tobacco and Other Substances
Measure Name:

Substances - Lifetime Use

Release Date:

February 6, 2009

Definition

Question asking the respondent if s/he has ever used a drug during his or her entire life.

Purpose

This measure can be used to assess the participant's lifetime use of any drug. The question is often used as a prelude to more detailed questions about substance use to screen out individuals who have ever used these substances.

Keywords

drugs, substance use, illicit substances, cannabis, marijuana, THC, hashish, LSD, acid, PCP, angel dust, phencyclidine, peyote, mescaline, psilocybin, ecstasy, MDMA, sedative, tranquilizer, anti-anxiety drug, painkiller, stimulant, prescription drug, cocaine, crack cocaine, hallucinogen, inhalent, solvent, heroin, substance abuse, sleeping pills, barbiturates, Seconal, Quaaludes, or Chloral Hydrate, Valium, Librium, muscle relaxants, Zanax, Codeine, Darvon, Percodan, Dilaudid, Demerol, Preludin, Benzedrine, Methadrine, uppers, speed, amyl nitrate, nitrous oxide, glue, tolune, gasoline, Alcohol Use Disorder and Associated Disabilities Interview Schedule, AUDADIS, National Institute on Alcohol Abuse and Alcoholism National Epidemiologic Survey on Alcohol and Related Conditions, NIAAA, NESARC, Diagnostic and Statistical Manual of Mental Disorders